LINEAGE-SPECIFIC HEMATOPOIESIS

Question 1

Regulated process of RBC production to maintain adequate numbers of erythrocytes in the peripheral blood.

Answer 1

ERYTHROPOIESIS

Question 2

Major cytokine of erythropoiesis

Answer 2

erythropoietin (EPO)

Question 3

80%-85% of the EPO comes from the

Answer 3

Kidney

Question 4

10%-15% of the EPO comes from the

Answer 4

liver

Question 5

DEFINITION: BFU-E

Answer 5

BURST FORMING UNIT - ERYTHROID

Question 6

1st identical precursor under light microscope

Answer 6

RUBRIBLAST

Question 7

multi-clustered large colonies of progenitor cells containing hemoglobin.
- has less EPO receptor
- capable of proliferation
- takes 1 week of differentiate to CFU-E

Answer 7

BFU-E

Question 8

DEFINITION: CFU-E

Answer 8

colony-forming unit - erythroid

Question 9

Smaller colonies. Has more EPO receptors and not capable of proliferation. BURST PRODUCTION OF PROGENITOR COLONIES

Answer 9

CFU-E

Question 10

1st earliest progenitor to have a matured RBC (18-21 days)

Answer 10

BFU-E

Question 11

1st identical precursor under the light microscope

Answer 11

Pronormoblast/Rubriblast/Proerythroblast

Question 12

~lineage specific glycoprotein, thermostable, non-dialyzable.
~molecular weight of 34kD

Answer 12

Erythropoietin (EPO)

Question 13

binds to the EPO gene causing increased EPO production.

Answer 13

Hypoxia Inducible Factors (HIFs)