Lincosamides Flashcards
1
Q
Are lincosamides lipid or water soluble?
A
Lipid soluble
2
Q
Are lincosamides bactericidal or bacteriostatic?
A
Bacteriostatic
3
Q
Do lincosamides work in purulent debris?
A
YES
4
Q
How are lincosamides eliminated?
A
Hepatic
5
Q
How do lincosamides work?
A
Inhibits protein synthesis at the 50S ribosomal subunit. Only crosses BBB with inflammation present.
6
Q
What are some mechanisms of resistance to lincosamides?
A
Gram - bacteria are resistant due to their thick cell wall.
Both chromosomal and plasma mediated resistance are common.
7
Q
Clindamycins
A
Staph, strep, and anaerobes + Toxoplasma and Mycoplasma
