Lifestyle Disorders Flashcards
Diabetes
Disease that occurs when blood glucose (blood sugar) is too high
Glucose absorption
1) Food is converted into glucose
2) As blood sugar levels rise the pancreas make insulin
3) Blood carries glucose and insulin to every cell in the body
4) Insulin acts like a key to “open” the cells
5) cells absorb glucose from the blood
Hyperinsulinemia
Pancreas starts to produce even more insulin to get blood sugar back to normal. As level of insulin in blood rises, glucose does not rise.
Hyperglycemia
When high insulin amount is not enough to utilize the glucose and blood glucose level start to increase
Glucose balance
In fasted state as blood glucose drops the pancreas’ secretes glucagon (insulin antagonist) such that liver breaks it down to glucose and goes into bloodstream
Blood sugar for diabetes
Btwn 4-5.4 mmol/L when fasting and up to 7.8 mmol/L 2 hrs after eating
Insulin resistance causes
Genetic abnormalities
Obesity
Inactive
Counter regulatory hormones
Immune mediated
Medications
Fetal malnutrition
Diagnose insulin resistance
Glucose tolerance test which is to drink 75 gm glucose w fluid in five minutes and the blood taken periodically to analyze for two hours = 2-h plasma glucose
Symptoms of. Hyperglycemia
Polyuria (increased urination), polydipsia (increased thrist) polyphagia (increase hunger), dry mouth, weakeness, headache and blurred vision
Diabetes mellitus
Disorder in which body does not respond to correctly to insulin causing blood sugar to high
Diabetes types
Type 1 - (IDDM) Insulin Dependent Diabetes mellitus occurs when pancreas cannot produce enough insulin to response to rise to blood glucose - take injections and developed genetic and early life development
Type 2 - (NIDDM) Non insulin dependent diabetes occurs due to increased insulin resistance or body loses ability to produce enough insulin. Age is above 45 yrs and manifests either genetic or sedentary lifestyle
Hypothyroidism
Thyroid gland is under active resulting in a deficiency of thyroid hormones T3 and T4
Thyroid gland
Located near throat where it weighs btwn 15-20 g and largest gland in endocrine system.
T3 and T4 dictate metabolism
Secretions of thyroid gland by TSH (Thryoid stimulating hormone) which is secreted by anterior (frontal side) pituitary gland located in brain. TRH (Thyrotrophin releasing hormone) secretes by hypothalamus of brain
Synthetisis and secretion of. Thyroid hormone
Iodine is combined with amino acid tyrosine to convert to T3 and T4. Majority of thyroid is T4 (93%) while T3 is 7% is secreted from thyroid gland. T3 is formed by removal of iodide atom from T4 in liver and kidney. T3 although short is more fast and intense than T4.
Causes of Hypothyroidism
Autoimmune thyroiditis (Hashimoto disease) - it is a chronic disease in which the body interprets the thyroid glands and its hormones as threats. The body therefore produces special antibodies which target these thyroid cells and destroy them.
• Thyroiditis, or inflammation of the thyroid gland.
• Congenital hypothyroidism, or hypothyroidism that is present at birth
• Surgical removal of part or all of the thyroid
• Radiation treatment of the thyroid which affects its cellular structure and function
Symptoms of hypothyroidism
• Weight gain
• Fatigue
• Cold intolerance
• Shortness of breath
• Constipation
• Fertility issues, and menstrual disturbances
• Muscle weakness, cramp
• Dry skin, hair loss
• Decreased kidney function
• Decreased overall heart function (left ventricular function decreases, cardiac output decrease)
Types of hypothyroidism
Primary - due to failure of thyroid function (most common) and autoimmune, (high concentrations of anti-thyroid antibodies). Hashimoto disease is the name of an autoimmune thyroid condition.
b. Secondary - due to inadequate secretion of TSH from pituitary or TRH from hypothalamus
c. Subclinical hypothyroidism - in this the secretion of T4 is normal but TSH levels are slightly high.
Goiter
Another type of hypothyroidism where thyroid gland is enlarged and this is due to iodine deficiency- common in older women
Dietary for hypothyroidism
Foods like cruciferous raw veg and soy products should not be consumed but cooked or boiled can be eaten in moderation
Adequate iron needed
Low impact exercise w low intensity resistance training
Rec to not take up cases where thyroid hormone are uncontrolled or too low
PCOS/ PCOD
Polycystic Ovarian Disease (PCOD) or Polycystic ovarian syndrome (PCOS) common hormonal disorder affecting women between puberty and menopause
Affects 5-10% women in reproductive age.
Women ovaries contain many round follicles and each contain an unfertilized egg but this disease ovaries are larger than normal and have lot of swollen follicles that turn into cysts
Women menstrual cycle
Four phases:
Menstrual phase - elimination of thicken lining of uterus (endometrium) from body through vaginaz menstrual fluid contains blood, cells from lining of uterus (endometrial cells) and mucus. Last 5-7 days
Follicular phase - starts on first day of menstrual and ends with ovulation. Hypothalamus release FSH (follicule stimulating hormone) which produce 5-20 focillies and each of them has egg where one of them matures it and every other one dies. Last for 10-28 and its thickening is preparation for pregnancy
Ovulation phase - egg releasing phase which occurs two weeks before menstrual cycle
Luteal phase - egg bursts from follicule during ovulation and transfer s into corpus luteum, a structure that release progesterone along with estrogen such that the fertilized egg is implanted in the uterus. This produces a hormone called human chorionic gonadotropin (HCG) to maintain the corpus luteum which produces the raised levels of progesterone that need to maintain the thickening lining of uterus. If pregnancy doesn’t happen, the corpus luteum dies usually around the 22-28 of cycle
Menstrual cycle and PCOS
Ovaries has cystic follicies w. Eggs but they do not develop and mature so there is ovulation or egg release which leads to increasing luteinizing hormones.
PCOS symptoms
Irregular menstruation, heavy periods, excess body or facial hair, pelvic pain, or difficulty getting pregnant
Two hormones related:
- Testosterone which produce small in woman’s ovaries. But it is higher in PCOS causing the unwanted hair
- Insulin - body may not respond to insulin such that glucose levels rising. And with insulin resistance which cause more insulin to be made causes ovaries to make excess testosterone
Diagnose PCOS
Irregular, infrequent, or no periods
Increase of facial or body hair
Test to show higher testosterone levels
Ultrasound scan that shows polycystic ovaries