Lifestyle Disorders Flashcards

1
Q

Diabetes

A

Disease that occurs when blood glucose (blood sugar) is too high

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2
Q

Glucose absorption

A

1) Food is converted into glucose

2) As blood sugar levels rise the pancreas make insulin

3) Blood carries glucose and insulin to every cell in the body

4) Insulin acts like a key to “open” the cells

5) cells absorb glucose from the blood

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3
Q

Hyperinsulinemia

A

Pancreas starts to produce even more insulin to get blood sugar back to normal. As level of insulin in blood rises, glucose does not rise.

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4
Q

Hyperglycemia

A

When high insulin amount is not enough to utilize the glucose and blood glucose level start to increase

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5
Q

Glucose balance

A

In fasted state as blood glucose drops the pancreas’ secretes glucagon (insulin antagonist) such that liver breaks it down to glucose and goes into bloodstream

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6
Q

Blood sugar for diabetes

A

Btwn 4-5.4 mmol/L when fasting and up to 7.8 mmol/L 2 hrs after eating

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7
Q

Insulin resistance causes

A

Genetic abnormalities
Obesity
Inactive
Counter regulatory hormones
Immune mediated
Medications
Fetal malnutrition

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8
Q

Diagnose insulin resistance

A

Glucose tolerance test which is to drink 75 gm glucose w fluid in five minutes and the blood taken periodically to analyze for two hours = 2-h plasma glucose

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9
Q

Symptoms of. Hyperglycemia

A

Polyuria (increased urination), polydipsia (increased thrist) polyphagia (increase hunger), dry mouth, weakeness, headache and blurred vision

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10
Q

Diabetes mellitus

A

Disorder in which body does not respond to correctly to insulin causing blood sugar to high

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11
Q

Diabetes types

A

Type 1 - (IDDM) Insulin Dependent Diabetes mellitus occurs when pancreas cannot produce enough insulin to response to rise to blood glucose - take injections and developed genetic and early life development

Type 2 - (NIDDM) Non insulin dependent diabetes occurs due to increased insulin resistance or body loses ability to produce enough insulin. Age is above 45 yrs and manifests either genetic or sedentary lifestyle

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12
Q

Hypothyroidism

A

Thyroid gland is under active resulting in a deficiency of thyroid hormones T3 and T4

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13
Q

Thyroid gland

A

Located near throat where it weighs btwn 15-20 g and largest gland in endocrine system.

T3 and T4 dictate metabolism

Secretions of thyroid gland by TSH (Thryoid stimulating hormone) which is secreted by anterior (frontal side) pituitary gland located in brain. TRH (Thyrotrophin releasing hormone) secretes by hypothalamus of brain

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14
Q

Synthetisis and secretion of. Thyroid hormone

A

Iodine is combined with amino acid tyrosine to convert to T3 and T4. Majority of thyroid is T4 (93%) while T3 is 7% is secreted from thyroid gland. T3 is formed by removal of iodide atom from T4 in liver and kidney. T3 although short is more fast and intense than T4.

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15
Q

Causes of Hypothyroidism

A

Autoimmune thyroiditis (Hashimoto disease) - it is a chronic disease in which the body interprets the thyroid glands and its hormones as threats. The body therefore produces special antibodies which target these thyroid cells and destroy them.
• Thyroiditis, or inflammation of the thyroid gland.
• Congenital hypothyroidism, or hypothyroidism that is present at birth
• Surgical removal of part or all of the thyroid
• Radiation treatment of the thyroid which affects its cellular structure and function

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16
Q

Symptoms of hypothyroidism

A

• Weight gain
• Fatigue
• Cold intolerance
• Shortness of breath
• Constipation
• Fertility issues, and menstrual disturbances
• Muscle weakness, cramp
• Dry skin, hair loss
• Decreased kidney function
• Decreased overall heart function (left ventricular function decreases, cardiac output decrease)

17
Q

Types of hypothyroidism

A

Primary - due to failure of thyroid function (most common) and autoimmune, (high concentrations of anti-thyroid antibodies). Hashimoto disease is the name of an autoimmune thyroid condition.
b. Secondary - due to inadequate secretion of TSH from pituitary or TRH from hypothalamus
c. Subclinical hypothyroidism - in this the secretion of T4 is normal but TSH levels are slightly high.

18
Q

Goiter

A

Another type of hypothyroidism where thyroid gland is enlarged and this is due to iodine deficiency- common in older women

19
Q

Dietary for hypothyroidism

A

Foods like cruciferous raw veg and soy products should not be consumed but cooked or boiled can be eaten in moderation
Adequate iron needed

Low impact exercise w low intensity resistance training

Rec to not take up cases where thyroid hormone are uncontrolled or too low

20
Q

PCOS/ PCOD

A

Polycystic Ovarian Disease (PCOD) or Polycystic ovarian syndrome (PCOS) common hormonal disorder affecting women between puberty and menopause

Affects 5-10% women in reproductive age.

Women ovaries contain many round follicles and each contain an unfertilized egg but this disease ovaries are larger than normal and have lot of swollen follicles that turn into cysts

21
Q

Women menstrual cycle

A

Four phases:

Menstrual phase - elimination of thicken lining of uterus (endometrium) from body through vaginaz menstrual fluid contains blood, cells from lining of uterus (endometrial cells) and mucus. Last 5-7 days

Follicular phase - starts on first day of menstrual and ends with ovulation. Hypothalamus release FSH (follicule stimulating hormone) which produce 5-20 focillies and each of them has egg where one of them matures it and every other one dies. Last for 10-28 and its thickening is preparation for pregnancy

Ovulation phase - egg releasing phase which occurs two weeks before menstrual cycle

Luteal phase - egg bursts from follicule during ovulation and transfer s into corpus luteum, a structure that release progesterone along with estrogen such that the fertilized egg is implanted in the uterus. This produces a hormone called human chorionic gonadotropin (HCG) to maintain the corpus luteum which produces the raised levels of progesterone that need to maintain the thickening lining of uterus. If pregnancy doesn’t happen, the corpus luteum dies usually around the 22-28 of cycle

22
Q

Menstrual cycle and PCOS

A

Ovaries has cystic follicies w. Eggs but they do not develop and mature so there is ovulation or egg release which leads to increasing luteinizing hormones.

23
Q

PCOS symptoms

A

Irregular menstruation, heavy periods, excess body or facial hair, pelvic pain, or difficulty getting pregnant

Two hormones related:
- Testosterone which produce small in woman’s ovaries. But it is higher in PCOS causing the unwanted hair
- Insulin - body may not respond to insulin such that glucose levels rising. And with insulin resistance which cause more insulin to be made causes ovaries to make excess testosterone

24
Q

Diagnose PCOS

A

Irregular, infrequent, or no periods

Increase of facial or body hair

Test to show higher testosterone levels

Ultrasound scan that shows polycystic ovaries

25
Management of PCOS
For physicians, the mnemonic "MYPCOS" is a way to organize multisystem care of women with polycystic ovary syndrome. MYCOS - Metabolic intervention, cycle control, Psycho-social care, Cosmetic treatment, Ovulation stimulation and managing Sleep apnea. • Metabolic - Lifestyle modification is first line therapy with weight loss (if overweight), a healthy diet, and regular exercise. Even without weight loss, moderate intensity exercise can improve the metabolic status of women with polycystic ovary syndrome. In adults and adolescents with PCOS, daily strict physical activity sessions for at least 30min/day or 150min/ week are recommended. • Cycle Control - menstrual cycles should be regulated such that menses occur at least every 3 months. The first-line approach is with hormonal contraceptives, and because metformin increases ovulation rate, it can be considered second-line treatment for cycle control. • Psychosocial - it is important to screen for depression and eating disorders in women with polycystic ovary syndrome. Patients can be effectively screened for depression by asking 2 simple questions about mood and their interest in various day to day activities. • Cosmetic - Excessive growth of dark or coarse hair in a male-like pattern - face, chest and back, acne and male pattern hair loss are very commonly seen in PCOS conditions. Hormonal therapy with estrogen-containing oral contraceptives or anti-androgens as above can be very effective for treating these cosmetic conditions. • Ovulation and Fertility - If fertility is desired, ways to increase ovulation frequency should be discussed. If the patient is obese, weight loss is recommended. Given the benefits of diet, exercise, and weight loss in overweight and obese individuals, healthy lifestyle changes are recommended. • Sleep Apnea - is a serious sleep disorder in which breathing repeatedly stops and starts. The risk and severity of obstructive sleep apnea in polycystic ovary syndrome is strongly correlated with insulin resistance. Treatment with at least four hours per night of continuous positive airway pressure improves insulin sensitivity.
26
Impact of Ageing
Change in body composition (muscle mass declines at rate of 1% annually after 30 yrs age with up 50% of muscle mass lost by the time they are 80s) Low musclar strength Sedentary lifestyle in late years results in low aerobic capacity and low bone mass density Low TDEE Hormonal changes affect the efficiency of metabolic systems and directly as well as indirectly affect muscle mass and bone loss (menopause - rate of muscle loss is 0.6% )
27
Ante-natal
Time leading to delivery
28
Time leading up to delivery and post delivery (postpartum) can lead to
Gestational Weight Gain (GWG) and Postpartum Weight Retention (PPWR)
29
Extra weight in pregnancy come from
Baby - 7.5 pounds Placenta - 1.5 pounds Amniotic fluid - 2 pounds Uterine enlargement- 2 pounds Maternal breast tissue - 2 pounds Maternal blood volume - 4 pounds Fluids in maternal tissue - 4 pounds Maternal fat stores - 7 pounds Most happen during 2-3 trimester
30
Physiological changes in pregnancy
Morning sickness - 90% of women experience nausea from week 5 to week 18. Meals should be broken down into smaller meals - no large spicy meals since might cause gastric stress Cardiovascular adaptation- increase in blood volume, heart rate and stroke volume where the cardiac output is 30% more in order to deliver nutrients to baby Changes in abdominal wall - lower ribs and diaphragm is spread out during early phase of pregency. Rectus abdominal is stretched out by 20cm and the two bands may stretch out to allow more space called diastasis recti and 66% suffer from this Pelvic floor - foetus grows the uterus expands. Urinary incontinence (leaking) is sign of damage to pelvic floor. Core and pelvic floor strengthening can be done during pregnancy and after delivery. Hormonal changes - HCG hormone is produced in first trimester which indicates the placenta is being created. progesterone causes mood swings. Estrogen increases blood flow while maintaining endometrial lining for baby development. Relaxin is produced in second trimester to help relax smooth muscles in pelvic region Changes in centre of mass - expanding uterus puts pressure on lower part of spine so due to action of relaxin and estrogen the pelvic widens while ligaments and joints become lax
31
Diet considerations for pregnancy
Energy req is 90. 300, 450 for first second and third trimesters respectively Supplemental of Zinc Iron Magnesium B6 Selenium and C
32
Exercises for Pregnancy
Swimming stationary cycling or walking Avoid exercises that might cause fall abdominal impact or joint stress Avoid any supine position activity (lying on back) exercises Benefits improved cardiovascular fitness, • Preventing excessive gestational weight gain, • Mood stability, • Boter pelvic control to manage urinary incontinence (but with specific exercises that target the pelvic muck) • Reducing the chances of gestational diabetes and hypertension • Higher chance of normal delivery
33
Postpartum
HCG hormone stops being produced after baby is delivered. Hypothalamus resumes which takes a while so women tend to eat more Also takes 6 weeks to reconvert from birth physically either though Caesarean or natural Breastfeeding cal is additional 670 on top of TDEE and protein requirements is 15-20 g p day extra Safe to exercise about days within delivery so light exercise for 4-6 weeks
34
Concerns about postpartum exercising
Sleep deprivation which is alleviated by exercising Vaginal bleeding starts immediately after delivery and uterine discharge continue for 8 weeks after Up to 60% of women suffer from urinary incontinuence due to pelvic trauma so strengthen pelvic muscles for 12-15 times, twice a day Diastasis recti which is resolved by itself and if not direct clients to physiotherapist. No exercises that cause bulging in stomach muscles like sit-up, leg raises in lying position or anything that create torque (twist) in their abdominal muscles