LFTs

Question 1

If ALT is raised, more than 10-fold, what type of injury is it most likely to be?

Answer 1

Hepatocellular

Question 2

If ALP is raised, more than 3-fold, what type of injury is it most likely to be?

Answer 2

Cholestatic

Question 3

If both ALT and ALP are significantly raised, what type of injury is it most likely to be?

Answer 3

Mixed hepatocellular and cholestatic picture

Question 4

What is a raised GGT suggestive of?

Answer 4

Cholestasis

Esp when combined with a raised ALP

Question 5

If ALT is higher than AST what does this suggest?

Answer 5

Chronic liver disease

Question 6

If ALP is raised but isolated, what does this suggest?

Answer 6

Bony metastases/primary bone tumours

Vitamin D deficiency/ recent bone fracture

Question 7

If AST is higher than ALT what does this suggest?

Answer 7

Cirrhosis

Acute alcoholic hepatitis

Question 8

What are low levels of albumin caused by?

Answer 8

Liver cirrhosis
Inflammation of the liver
Nephrotic syndrome

Question 9

What does increased prothrombin time indicate?

Answer 9

Hepatocellular injury

Question 10

When a patient presents with normal urine, normal stools and increased bilirubin, what does this indicate?

Answer 10

A pre-hepatic cause of hepatic disease

Question 11

When a patient presents with dark urine, normal stools and increased bilirubin, what does this indicate?

Answer 11

A hepatic cause of hepatic disease

Question 12

When a patient presents with dark urine, pale stools and increased bilirubin, what does this indicate?

Answer 12

A post-hepatic cause of hepatic disease