levinson questions Flashcards

1
Q

169: each of the following statements concerning retroviruses is correct except:
A: the virion carries an RNA-directed DNA polymerase encoded by the viral genome
B: the viral genome consists of three segments of double-stranded RNA
C: the virion is enveloped and enters cells via an interaction with specific receptors on the host cell
D: during infection, the virus synthesizes a DNA copy of its RNA, and this DNA becomes covalently integrated into host cell DNA

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q
183: each of the following viruses possesses an outer envelope of lipoprotein except:
A: varicella-zoster virus
B: papillomavirus
C: influenza virus
D: human immunodeficiency virus
A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q
186: each of the following viruses possesses a DNA polymerase in the virion except:
A: human immunodeficiency virus
B: human t-cell lymphotropic virus
C: EBV
D: hep B
A

C`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

192: each of the following statements about HIV is correct except:
A: HIV is an enveloped RNA virus
B: the virion contains an RNA-dependent DNA polymerase
C: a DNA copy of the HIV genome integrates into host cell DNA
D: acyclovir inhibits HIV replication

A

D`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

250: each of the following statements concerning HIV is correct except:
A: screening tests for antibodies are useful to prevent transmission of HIV through transfused blood
B: the opportunistic infections seen in AIDS are primarily the result of a loss of cell-mediated immunity
C: Zidovudine (azidothymidine) inhibits the RNA-dependent DNA polymerase
D: the presence of circulating antibodies that neutralize HIV is evidence that an individual is protected against HIV-induced disease

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

273: each of the following statements concerning human immunodeficiency virus is correct except:
A: the CD4 protein on the T-cell surface is one of the receptors for the virus
B: there is appreciable antigenic diversity in the envelope glycoprotein of the virus
C: one of the viral genes codes for a protein that augments the activity of the viral transcriptional promoter
D: a major problem with testing for antibody to the virus is its cross-reactivity with human t-cell lymphoma virus type I

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

274: each of the following statements concerning human immunodeficiency virus is correct except:
A: patients infected with HIV typically form antibodies against both the envelope glyco-proteins (gp120 and gp41) and the internal group-specific antigen (p24)
B: HIV probably arose as an endogenous virus of humans because HIV proviral DNA is found in the DNA of certain normal human cells
C: transmission of HIV occurs primarily by the transfer of blood or semen in adults, and neonates can be infected at the time of delivery
D: the western blot test is more specific for HIV infection than the ELISA is

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

For each numbered item, select the one lettered option that is most closely associated with it.

A: HPV
B: hep A
C: rotavirus
D: adenovirus
E: hepatitis delta virus (HDV)
F: parvovirus B19
G: HIV
H: hep B
I: sin nombre virus (hantavirus)
J: human t-cell lymphotropic virus
K: prion
L: hep C

582: most important cause of diarrhea in infants

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

For each numbered item, select the one lettered option that is most closely associated with it.

A: HPV
B: hep A
C: rotavirus
D: adenovirus
E: hepatitis delta virus (HDV)
F: parvovirus B19
G: HIV
H: hep B
I: sin nombre virus (hantavirus)
J: human t-cell lymphotropic virus
K: prion
L: hep C

583: a vaccine containing purified viral protein is available

A

H

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

For each numbered item, select the one lettered option that is most closely associated with it.

A: HPV
B: hep A
C: rotavirus
D: adenovirus
E: hepatitis delta virus (HDV)
F: parvovirus B19
G: HIV
H: hep B
I: sin nombre virus (hantavirus)
J: human t-cell lymphotropic virus
K: prion
L: hep C

584: defective virus with an RNA genome

A

E

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

block one, 29:

A

`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

block one, 40:

A

`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

block two, 39:

A

`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

clinical case 28: your patient is a 35-year-old man who is HIV antibody-positive and has a CD4 count of 85 cells. he recently had a seizure, and an MRI scan indicates a lesion in the temporal lobe. a brain biopsy specimen reveals multinucleated giant cells with intranuclear inclusions.

626: of the following, which one is the most likely cause?
A: herpes simplex virus-type 1
B: parvovirus B19
C: coxsackie virus
D: western equine encephalitis virus
A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q
185: each of the following viruses possesses an RNA polymerase in the virion except:
A: hep A
B: smallpox
C: mumps
D: rotavirus
A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

190: each of the following statements about both influenza virus and rabies virus is correct except:
A: they are enveloped RNA viruses
B: their virions contain an RNA polymerase
C: a killed vaccine is available for both viruses
D: they each have a single antigenic type

A

D`

17
Q

218: each of the following statements concerning the rabies vaccine for use in humans is correct except:
A: the vaccine contains live, attenuated rabies virus
B: if you patient is bitten by a wild animal, the rabies vaccine should be given
C: when the vaccine is used for postexposure prophylaxis, rabies immune globulin should also be given
D: the virus in the vaccine is grown in human cell cultures, thus decreasing the risk of allergic encephalitis

A

A

18
Q

222: a 45-year-old man was attacked by a bobcat and bitten repeatedly about the face and neck. the animal was shot by a companion and brought back to the public health authorities. once you decide to immunize against rabies virus, how would you proceed?
A: use hyperimmune serum only
B: use active immunization only
C: use hyperimmune and active immunization
D: use active immunization and follow this with hyperimmune serum if adequate antibody titers are not obtained in the patient’s serum

A

C

19
Q

228: a 20-year-old man, who for many years had received daily injections of growth hormone prepared from human pituitary glands, develops ataxia, slurred speech, and dementia. at autopsy the brain shows widespread neuronal degeneration, a spongy appearance due to many vacuoles between the cells, no inflammation, and no evidence of virus particles. The most likely diagnosis is:
A: herpes encephalitis
B: creutzfeldt-jakob disease
C: subacute sclerosing panencephalitis
D: progressive multifocal leukoencephalopathy
E: rabies

A

B`

20
Q

240: the eradication of smallpox was facilitated by several features of the virus. which one of the following contributed least to eradication?
A: it has one antigenic type
B: inapparent infection is rare
C: administration of live vaccine reliably induces immunity
D: it multiplies in the cytoplasm of infected cells

A

D`

21
Q

258: each of the following statements concerning rabies and rabies virus is correct except:
A: the virus has a lipoprotein envelope and single-stranded RNA as its genome
B: the virus has a single antigenic type (serotype)
C: in the US, dogs are the most common reservoir
D: the incubation period is usually long (several weeks) rather than short (several days)

A

C

22
Q

block one, 15:

A

`

23
Q

clinical case 36: a 35-year-old man is seen in the emergency room complaining of severe headache and vomiting that began last night. his temperature is 40 C. while in the ER, he is increasingly combative and has a grand mal seizure. he is “foaming at the mouth” and cannot drink any liquids. analysis of his spinal fluid reveals no abnormality, and no organisms are seen in the gram stain. two days later, despite supportive measures, he dies. pathologic examination of the brain reveals eosinophilic inclusion bodies in the cytoplasm of neurons. diagnosis?

A

rabies caused by rabies virus. the inclusions are negri bodies. diagnosis can be confirmed by using fluorescent antibody assays. the patient was a farm worker who was bitten by a bat about a month prior to the onset of symptoms. note the long incubation period, which can be as long as 6 months. people bitten by a bat (or any wild animal) should receive rabies immunization consisting of the inactivated vaccine plus rabies immune globulins.

24
Q

clinical case 14: your patient is a 9-year-old boy who was sent home from school because his teacher thought he was acting strangely. this morning, he had a seizure and was rushed to the hospital. on physical examination, his temperature is 40 C adn he has no nuchal rigidity. a ct scan is normal. a lumbar puncture is done, and the spinal fluid protein and glucose are normal. a gram stain of the spinal fluid reveals no organisms and no polys. he is treated with various antibiotics but becomes comatose and dies 2 days later. the blood culture and spinal fluid culture grow no bacteria or fungi. on autopsy of the brain, eosinophilic inclusion bodies are seen in the cytoplasm of neurons.

609: of the following, which one is the most likely cause?
A: prions
B: JC virus
C: rabies virus
D: herpes simplex virus type 1
A

C

25
Q

For each numbered item, select the one lettered option that is most closely associated with it.

A: influenza virus
B: adenovirus
C: hep A
D: hep B
E: herpes simplex
F: measles virus
G: HIV
H: rabies virus
I: rotavirus

569: nonenveloped virus with single-stranded, positive polarity RNA

A

C

26
Q

For each numbered item, select the one lettered option that is most closely associated with it.

A: influenza virus
B: adenovirus
C: hep A
D: hep B
E: herpes simplex
F: measles virus
G: HIV
H: rabies virus
I: rotavirus

570: enveloped virus with two identical strands of positive polarity RNA

A

G

27
Q

For each numbered item, select the one lettered option that is most closely associated with it.

A: influenza virus
B: adenovirus
C: hep A
D: hep B
E: herpes simplex
F: measles virus
G: HIV
H: rabies virus
I: rotavirus

571: enveloped virus with double-stranded DNA and DNA polymerase in the virion

A

D

28
Q

For each numbered item, select the one lettered option that is most closely associated with it.

A: influenza virus
B: adenovirus
C: hep A
D: hep B
E: herpes simplex
F: measles virus
G: HIV
H: rabies virus
I: rotavirus

572: enveloped virus with segmented, negative-polarity, single-stranded RNA

A

A

29
Q

For each numbered item, select the one lettered option that is most closely associated with it.

A: influenza virus
B: adenovirus
C: hep A
D: hep B
E: herpes simplex
F: measles virus
G: HIV
H: rabies virus
I: rotavirus

573: non-enveloped virus with segmented double-stranded RNA

A

I