Leukotrienes related drugs

Question 1

Leukotrienes are

Answer 1

1. Produced by mast cells, esinophils, neutrophils
2. agonists at cysteinyl-leukotriene receptors (CysLR)
3. cause smooth muscle contracting in bronchioles
4. increases mucus production

Question 2

Leukotriene targeting drugs

Answer 2

Montelukast
Zafirlukast
target the leukotriene receptor

Question 3

Everything Montelukast and Zafirlukast

Answer 3

1. good against exercise induced asthma
2. good against aspirin induced asthma

Given orally (sorry michael no anal)

Question 4

Aspirin as danger for asthmatics

Answer 4

aspirin can cause cycloxygenase (COX) which usually synthesised prostanoids from arachidonic acid, to stop. Once stopped the arachidonic acid produces leukotrienes with all their related effects instead