angina Flashcards
1
Q
What is angina?
A
heart temporarily deprived of oxygen
2
Q
3 pain mediators released when cardiac cells become ischaemic
A
adenosine, bradykinin, potassium
3
Q
types of angina
A
Stable (angina of effort)
Unstable (brittle)
Variant (Prinzmetal’s)
4
Q
cause of stable angina
A
atherosclerosis of coronary arteries
5
Q
triggers of stable angina
A
exercise
cold weather
excitement
6
Q
what is Unstable angina associated with?
A
disruption of pre-existing atherosclerotic plaque or superimposition of a thrombus
7
Q
treatment of stable angina
A
Aspirin - to prevent platelet aggregation statins - lipid lowering drug organic nitrates ca channel blocker K channel activator
8
Q
how do organic nitrates work?
A
by dilating peripheral capacitance vessels thus reducing venous return and hence workload. They also decrease afterload - the force that heart has to generate to eject blood from ventricles
