Leukotriene Receptor Antagonists Flashcards
1
Q
Give examples of leukotriene receptor antagonists (LTRAs).
A
Montelukast, zafirlukast.
2
Q
How do leukotriene receptor antagonists work?
A
Block the effects of inflammatory mediators called leukotrienes, in the airways.
3
Q
There is a risk of hepatic disorders with the use of leukotriene receptor antagonists (LTRAs), especially with zafirlukast. What signs and symptoms may indicate this?
A
Persistent nausea, vomiting, malaise, jaundice, dark urine.
4
Q
Churg-Strauss syndrome is a rare complication seen with leukotriene receptor antagonist. What are the signs and symptoms of this?
A
Eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, peripheral neuropathy.