Leukotriene Receptor Antagonist

Question 1

Leukotriene Receptor Antagonist Drug Names

Answer 1

Zafirluskast

Montelukast

Question 2

Leukotriene Receptor Antagonist Therapeutic Actions

Answer 2

• Selective and competitively block or antagonize receptors for the production of leukotrienes
• I have an immediate effect

Question 3

Leukotriene Receptor Antagonist Indications

Answer 3

• Prophylaxis & chronic treatment of bronchial asthma

Question 4

Leukotriene Receptor Antagonist Contraindications and Cautions

Answer 4

Contraindication
	Acute asthma attack
Caution
	Hepatic or renal impairment
	Pregnancy and lactation

Question 5

Leukotriene Receptor Antagonist DDI

Answer 5

Propranolol, theophylline, terfenadine, warfarin, calcium channel blockers, cyclosporine, or aspirin

Question 6

Leukotriene Receptor Antagonist Adverse Effects

Answer 6

• URI, pharyngitis, cough
• CNS: Headache, dizziness
• GI: nausea, diarrhea, vomiting, abdominal pain, elevated liver enzymes
• generalized pain, fever, myalgia
• Mood changes

Question 7

Leukotriene Receptor Antagonist:

Assessment

Answer 7

Assessment
History
Contraindications: Allergy, acute bronchospasm or asthmatic attack
Caution: Impaired renal or hepatic function, pregnancy and lactation
Physical
Temperature, respirations, and lung sounds
CNS: Orientation and affect
Abdominal evaluation
Labs: liver and renal function tests

Question 8

Leukotriene Receptor Antagonist:

Diagnosis

Answer 8

Diagnosis
Risk for injury
Acute pain
Deficient knowledge

Question 9

Leukotriene Receptor Antagonist:

Implementation

Answer 9

Implementation
Take on an empty stomach
Safety measures
Patient teaching

Question 10

Leukotriene Receptor Antagonist:

Evaluation

Answer 10

Evaluation
Patient response
Effectiveness of teaching plan
Effectiveness of comfort measures/non-pharmacologic measures