Leukocytes | White Blood Cells Flashcards by Taylor Davison

Neutrophils (Segs) are visually distinct during a differential by their?

Dark, dense nucleus that can be any shape
with a Clear cytoplasm.
May have light pink dust like granuals

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are visually distinct during a differential by their?

Neutrophils (Segs)

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Band Neutrophils are visually distinct during a differential by their?

Horseshoe shaped nucleus
Smooth margins to nucleus, any indentation must be less than 1/3 the width of nucleus

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Lymphocytes are visually distinct during a differential by their?

Large, round, dense nucleus
Round cell
Little cytoplasm, blue cytoplasm

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Immunocytes are visually distinct during a differential by their?

Larger cell, more cytoplasm
Dark blue edge to membrane

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Monocytes are visually distinct during a differential by their?

Large cell
Lacy nucleus (can be any shape)
Blue gray cytoplasm
Can have vacuoles

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Band Neutrophils are?

Immature Neutrophils pushed into circulation prematurely

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Name the White Blood Cell:

Lymphocyte

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Name the White Blood Cell:

Lymphocyte

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Immunocytes are?

Antigenically stimulated lymphocyte

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Name the White Blood Cell:

Immunocytes

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Name the White Blood Cell:

Immunocyte

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Name the White Blood Cell:

Monocyte

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Name the White Blood Cell:

Monocyte

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Eosinophils are visually distinct during a differential by their?

Granules some shade of red
Can see light through granules

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Name the White Blood Cell:

Eosinophil

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Name the White Blood Cell:

Eosinophil

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Define: Antigen (Ag)

substance that elicits (triggers) specific immune response when present in the body

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Define: Antibody (Ab)

– specialized protein produced in response to an Antigen (Ag) - gamma globulins (immunoglobulins )

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Antibody IgG, IgM protect against?

bacteria, viruses

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Antibody IgE protect against?

– allergic responses

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Antibody IgA protect against?

protect GI, urogenital, & respiratory tracts

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Antibody IgD protect against?

present on the surface of some lymphocytes (B-lymphs) which initiate a humoral immune response

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lymphocytes (B- lymphs) role in immunity is?

initiate humoral immune response

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Neutrophils function are?

- First line of defense against infection by migrating to any area invaded by bacteria - Can also break down necrotic tissue - Highly phagocytic and motile

Average transit time for neutrophils in blood is?

10 hours

All neutrophils are replaced every?

about 2.5/day

Neutrophils move from ______ into _____ Once in tissues, cannot come back into _____ . & are lost where?

Neutrophils move from the bloodstream into the tissues & Once in the tissues they cannot come back into the blood stream. Lost in secretions, excretions through mucous membranes

Eosinophils function are?

- Ingest products of Ab/Ag reactions - Attracted by & inhibit allergic/anaphylactic reactions - Anti-parasitic - Phagocytic - Bactericidal - Normally scarce in blood stream but will see an Increase during parasitic infections & hypersensitivity (allergic reactions)

Basophils function are?

Role in immunity unclear Release Histamine & Heparin

Lymphocytes function are?

- Main function is immunity - Lymphocytes can form hundreds of different types of sensitized lymphocytes and antibodies. Each type is specific for a particular antigen and is capable of multiplying into large numbers of clones when excited by that antigen. - Antigens stimulate B-lymphocytes to divide and/or transform into cells that produce immunoglobulins (Ab)

What are the two type of Lymphocytes?

1. T-Lymph Cells 2. B-Lymph Cells

What are T Lymphocytes (T Cells)?

Cell Mediated Immunity. “Free Floating” - Has antigens receptors on surface of their body cells that allow them to give specific immune response to INTRACELLULAR phase of viral infection,fungi, parasites, bacteria. - Does NOT secrete antibodies. - Will lyse or kill body cells to get to the infection. - They attract neutrophils to phagocyte the dead cells.

What are B Lymphocytes (B Cells)?

Humoral immunity - Deal with antibodies that are free floating in the EXTRACELLULAR fluid blood, plasma, and lymph - Produces antibodies & release them into blood and lymph against various of antigens - Specific immune resistance to most bacteria, extracellular phase of viral infections - Antibodies produced by plasma cells circulate as what are now called free gamma globulin that are essentially plasma proteins - Some B cells divide into memory cells

About what percent of lymphocytes are seen in the blood stream?

10%

The majority of Lymphocytes seen on a blood smear are?

T cells since they are free floating

T Cells travel via the?

Bloodstream to the thymus gland where they mature & are introduced to “self” & sent back into the bloodstream to hangout & wait for antigens

B cells travel via?

The bloodstream to the liver, spleen & lymph nodes where they mature & stay.

The average transient time for Lymphocytes in the blood?

30 mins.

Where are Increased numbers of lymphocytes seen?

in the lymph nodes & spleen

What are Monocytes function?

Eat all the big chunky stuff - Phagocytosis and digestion of particulate and cellular debris.

What are produced by Monocytes?

1. Interferon Proteins 2. Transferrin Proteins

What is Interferon?

A protein produced by Monocytes when the body is exposed to viral antigens & has Ant-Tumor qualities.

What is Transferrin?

∆ A protein produced by monocytes that transport Iron

monocyte blood transit time is?

24-36 hours

What are Macrophages? & there function?

∆ Large phagocytic cells. ∆ Monocytes that have left the blood vessels and entered the tissues where they grew very large in size. Function: ∆ Ingest bacteria and other foreign substances

What percentage of Neutrophils are seen in Dogs?

60-70%

What percentage of Lymphocytes are seen in Dogs?

10-40%

What percentage of Eosinophils are seen in Dogs?

0-10%

What percentage of Monocytes are seen in Dogs?

0-10%

What percentage of Basophils are seen in Dogs?

Rare

What percentage of Neutrophils are seen in Feline?

60-70%

What percentage of Lymphocytes are seen in Feline?

10-40%

What percentage of Eosinophils are seen in Feline?

0-10%

What percentage of Monocytes are seen in Feline?

0-10%

What percentage of Basophils are seen in Feline?

Rare

What percentage of Neutrophils are seen in Equine?

60-70%

What percentage of Lymphocytes are seen in Equine?

10-40%

What percentage of Eosinophils are seen in Equine?

0-10%

What percentage of Monocytes are seen in Equine?

0-10%

What percentage of Basophils are seen in Equine?

Rare. Besides in old horses

What percentage of Neutrophils are seen in Bovine?

10-40%

What percentage of Lymphocytes are seen in Bovine?

60-70%

What percentage of Eosinophils are seen in Bovine?

0-10%

What percentage of Monocytes are seen in Bovine?

0-10%

What percentage of Basophils are seen in Bovine?

Rare

Leukocytes | White Blood Cells Flashcards

(66 cards)