Leukocytes: Maturation and Function Flashcards
1
Q
What cells do Myelopoiesis include?
A
- Neutrophils
- Eosinophils
- Basophils
- Monocytes
2
Q
What are the three Granulocytes?
A
- Neutrophils
- Eosinophils
- Basophils
3
Q
What is the storage and delivery of granulocytes?
A
- Stored in Bone marrow for 7-11 days
- Stored in peripheral blood for 7 hours (1/2 circulate, 1/2 marginate)
4
Q
Granulocyte Maturation
A
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band
- Segmented (Polymorphonuclear) Cell
5
Q
Neutrophils
A
- migrate to areas of tissue damage/infection
- Phagocytize and kill invading organisms
- 55-65% of leukocytes
6
Q
Eosinophil
A
- associated with allergic reactions, parasitic infections, and chronic inflammation
- Granules have cytotoxic effect on parasites and bacteria, stimulate release of histamine from basophils and mast cells
- 2-8% of leukocytes
7
Q
Basophil
A
- Mediate inflammatory responses, especially hypersensitivity and allergic responses
- Enzymes contained in granules are vasoactive, bronchoconstrictive, and chemotactic
- 0-1% of leukocytes
8
Q
Monopoiesis
A
- Monoblast
- Promonocyte
- Monocyte
9
Q
Macrophage
A
- present antigents to T cells and B cells
- phagocytize
- large (40-50 micron)
- 3.5 times more circulation than marginating
10
Q
Monocyte
A
- initiate immune response
- transform to macrophages in tissues
- remain in bloodstream for 30 hours before entering tissue
- 2-8% leukocytes
11
Q
Monocytosis
A
- neoplastic disorders (CML, CMML, Hodgkins)
- inflammation
- immune disease
- collagen disease
- infection (TB, syphilis)
12
Q
Lymphopoiesis
A
- Lymphoblast
- Prolymphocyte
- Lymphocyte
13
Q
Lymphocyte
A
- regulate immune response
- B cells
- T cells
- NK cells
- 25-35% leukocytes
14
Q
B cells
A
- lymphocyte
- humoral response
- derived from bone marrow
15
Q
T cells
A
- lymphocyte
- cellular response
- derived from thymus
- T helper (CD4)
- T cytotoxic (CD8)
