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Hema 1 > Leukocyte Disorders part 1 & 2 > Flashcards

Leukocyte Disorders part 1 & 2 Flashcards

1
Q

Quantitative term in terms of decrease RBC, WBC, and platelets?

A

Pancytopenia

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2
Q

Absolute count of neutrophilia?

A

> 7.0 - 8.0 x 10^9/L

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3
Q

Treatment for neutrophilia?

A

Corticosteroids and lithium

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4
Q

Usually transient or short-term increase of WBC?

A

Physiologic neutropenia

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5
Q

Most common type of leukopenia?

A

Neutropenia

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6
Q

Felty’s syndrome is due to?

A

Neutropenia

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7
Q

A drug that induced neutropenia?

A

Amidopyrine and cephalosphorins

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8
Q

5 clinical manifestations of Felty’s syndrome?

A

“SANTA”
Spenomegaly
Anemia
Neutropenia
Thrombocytopenia
Arthritis

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9
Q

Absolute count of eosinophilia?

A

0.4 x 10^9/L

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10
Q

Increased when there is an allergic reactions, pulmonary disorders, gastrointestinal disorders, infections such as scarlet fever, HIV infection, and infestation of tissue-invading parasites?

A

Eosinophilia

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11
Q

Difficult to detect using routine differentials and total leukocyte count?

A

Eosinopenia

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12
Q

This is caused by ACTH administration or Thorn’s test?

A

Eosinopenia

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13
Q

This is a common cause in the presence of malignant myeloproliferative neoplasm?

A

Basophilia

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14
Q

This is associated and relatively a recovery from neutropenia?

A

Monocytosis

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15
Q

Absolute monocyte count of monocytosis?

A

> 0.9 x 10^9/L

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16
Q

A very rare condition of leukopenia that is found in patients receiving steroid therapy?

A

Monocytopenia

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17
Q

Hallmark of pernicious anemia?

A

Hyepersegmented neutrophil

> 2-5 lobes
polycyte and macropolycyte

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18
Q

Termed as disappearance of nucleus or smaller nucleus?

A

Pyknocyte

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19
Q

Virocyte or Atypical Lymphocyte is also known as?

A

Downey Type Cell and Turk Irritation Cell

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20
Q

This cell is activated to respond a viral infection?

A

Atypical lymphocyte

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21
Q

This cell is seen in acute myeloid leukemia (AML)

A

Reider cell

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22
Q

Usually signs of degeneration in severe infections, chemical poisoning, and leukemia?

A

Vacuolated cell

23
Q

This lymphocyte abnormality is seen in chronic lymphocytic leukemia (CLL)

A

Basket cell or Smudge cell

24
Q

Cell that can be seen in patients having Systemic Lupus Erythematosus?

A

L.E. cell

25
Q

PMN which had engulfed the nuclear material of another PMNs or a lymphocyte?

A

L.E. cell

26
Q

A condition in which monocyte engulfed the nucleus of a lymphocyte or maybe whole lymphocyte itself and this strongly exhibits nucleophagocytosis?

A

Tart cell

27
Q

This cell exhibits hairy cell leukemia and a type of lymphocyte with hair like cytoplasmic projections?

A

Hairy cell

28
Q

This cell is commonly seen in a condition called Sezary syndrome and Mycosis fungoides?

A

Sezary cell

29
Q

This abnormal inclusion body that is classified as always pathological and is spindle in shape and red-purple in color?

A

Auer bodies/Rods

30
Q

Classified as azurophilic granules?

A

Auer bodies

31
Q

This inclusion bodies are frequently seen in aplastic anemia and in myelosclerosis?

A

Toxic granules

32
Q

Inclusion body that stains blue-gray and is usually seen in the periphery of the cytoplasm of neutrophils?

A

Dohle-Amato bodies

33
Q

Remnants of free ribosomes and mostly seen in bacterial infections, severe burns, exposure to cytotoxic agents, and complicated pregnancies?

A

Dohle-Amato bodies

34
Q

Inclusion body that is found in the cytoplasm if multiple myeloma and plasma cells after therapy with amidine drugs?

A

Snapper-Scheid bodies

35
Q

Gamma-globulins bodies that gave a grape or berry or morula cell appearance?

A

Russel or Fuch’s bodies

36
Q

2 groups of leukocyte disorders?

A

Non-Neoplastic Disorders and Neoplastic and Related Disorders

37
Q

Disorder of nucleus associated with abnormal DNA synthesis and is seen in megaloblastic anemia, it also causes shift to the right?

A

Hypersegmented neutrophil

38
Q

Decrease segmentation of neutrophil and usually has “pinceness appearance”

A

Pelger-Guet anomaly

39
Q

This is also known as true or congenital PHA and lamin-B receptor is defected.

A

Pelger-Huet anomaly

40
Q

Pelger-Huet anomaly is commonly seen in conditions such as?

A

CML (chronic myelogenous leukemia) and CMDS (chronic myeloproliferative disorder or sydrome)

41
Q

Anomaly that affect all WBC lineage in terms of nuclear shape and chromatin structure?

A

True-Pelger-Huet anomaly

42
Q

Another type of anomaly that only affects the nucleus of neutrophils and has a less dense nuclei?

A

Pseudo-Pelger-Huet anomalu

43
Q

Cytoplasm disorder that is usually seen in hunter’s syndrome and hurter’s syndrome?

A

Alder-Reily anomaly

44
Q

This has large peroxidase lysosomes inclusions that are deficient in enzymes for phagocytosis. This is also associated with albinism as clinical condition?

A

Chdiak-Higashi syndrome

45
Q

This is caused by the mutation in the MYH9 gene?

A

May-Hegglin anomaly

46
Q

Functional disorder in which random movement of phagocytes is normal, but directional motility is impaired.

A

Job’s syndrome

47
Q

Functional disorder of leukocyte that is characterized by both random and directed movement of the cells are defective.

A

Lazy Leukocyte syndrome

48
Q

Intracellular killing of granulocyte is then defective and usually seen in childhood?

A

Chronic Granulomatous disease

49
Q

Type of Gaucher’s disease characterized by a defect or change in acute neuronopathic and is associated with infancy?

A

Type 2 Gaucher’s disease

50
Q

Type of Gaucher’s disease that is characterized by sub-acute neuronopathic and is associated with childhood type?

A

Type 3 Gaucher’s disease

51
Q

It is an inherited leukocyte disorder in which caused by a mutation in the lamin-B receptor?

A

Pelger-Huet anomaly

52
Q

It is loss of both T and B cells function and is an autosomal recessive disorder?

A

Swiss-Type Aggamaglobulinema

53
Q

Decrease T-cell production and associated in rare childhood disease and which affects the brain and other parts of the body?

A

Ataxia Talengiectasia

54
Q

The expected CBC results for women in active labor would be?

A

High total WBC count with a slight shift to the left in neutrophils

Hema 1 (2 decks)

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