Leukocyte Disorders Ciulla 4thEd - Hema 2 EE Flashcards
In patients with infectious mononucleosis, which blood cells are infected by the causative agent?
A. Monocytes
B. Tlymphocytes
C. B lymphocytes
D. Histiocytes
C. B lymphocytes
Which of the following statements about hairy cell leukemia is true?
A. It is an acute disease, primarily affecting young adults.
B. Splenomegaly is an unusual finding.
C. Hairy cells contain tartrate-resistant acid phosphatase.
D. Hairy cells are abnormal T lymphocytes.
C. Hairy cells contain tartrate-resistant acid phosphatase.
Based on the WHO classification system, B cell ALL (FAB type L3) and represent different clinical presentations of the same disease entity.
A. Burkitt lymphoma
B. Hodgkin lymphoma
C. Mycosis fungoides
D. Small lymphocytic lymphoma
A. Burkitt lymphoma
The presence of both immature neutrophils and nucleated erythrocytes in the peripheral blood is most accurately called a
A. Neutrophilic left shift
B. Regenerative left shift
C. Neutrophilic leukemoid reaction
D. Leukoerythroblastic reaction
D. Leukoerythroblastic reaction
In which anomaly is a failure of granulocytes to divide beyond the band or two-lobed stage observed?
A. Pelger-Huet
B. May-Hegglin
C. Alder-Reilly
D. Chediak-Higashi
A. Pelger-Huet
In which of the following are eosinophils not increased?
A. Cushing syndrome
B. Allergic disorders
C. Skin disorders
D. Parasitic infection
A. Cushing syndrome
Which of the following represents the principal defect in chronic granulomatous disease (CGD)?
A. Chemotactic migration
B. Phagocytosis
C. Lysosomal formation and function
D. Oxidative respiratory burst
D. Oxidative respiratory burst
The blood shown in Color Plate 11• is from a leukemia patient following treatment. These findings are most suggestive of therapy with
A. Corticosteroids (e.g., prednisone)
B. A folate antagonist (e.g.,methotrexate)
C. Recombinant erythropoietin
D. Chloramphenicol
B. A folate antagonist (e.g.,methotrexate)
A patient with normal hemoglobin and WBC count values, a persistently elevated platelet count (over 1000 X 109/L), increased marrow megakaryocytes, and a history of frequent bleeding and clotting episodes most likely has
A. Polycythemia vera
B. Chronic myelofibrosis
C. Essential thrombocythemia
D. Chronic myelogenous leukemia
C. Essential thrombocythemia
An adult patient with massive splenomegaly has mild anemia, a slightly elevated WBC count, and an LAP score of 170. The blood smear shows teardrop erythrocytes and leukoerythroblastosis. These findings are most consistent with
A. Chronic myelogenous leukemia
B. Idiopathic myelofibrosis
C. Primary polycythemia
D. Primary thrombocythemia
B. Idiopathic myelofibrosis
Which of the following infections does not reveal a blood picture as seen in Color Plate 12B?
A. Epstein-Barrvirus(EBV)
B. Bordetella pertussis (whooping cough)
C. Cytomegalovirus (CMV)
D. Toxoplasma gondii (toxoplasmosis)
B. Bordetella pertussis (whooping cough)
The most common type of chronic lymphocytic leukemia (CLL) in the United States involves the
A. B cell
B. NK cell
C. T cell
D. Plasma cell
A. B cell
Which of the following are characteristic findings in Waldenstrom disease?
A. Increased IgA and hepatosplenomegaly
B. Increased IgE and renal failure
C. Increased IgG and hypercalcemia
D. Increased IgM and blood hyperviscosity
D. Increased IgM and blood hyperviscosity
Which of the following would not cause a total WBC count of 62.2 X 109/L (62.2 X 103/jjLL) and the blood findings seen in Color Plate 13B?
A. Treatment with myeloid growth factors
B. Gram-negative septicemia
C. Human immunodeficiency virus (HIV)
D. Systemic fungal infection
C. Human immunodeficiency virus (HIV)
The peripheral blood shown in Color Plate 14B is from a 69-year-old female. Her WBC count was 83.0 X 109 cells/L (83.0 X 103/(xL) and her platelet count was normal. Based on the cell morphology and this information, what is the most likely diagnosis?
A. Acute lymphoblastic leukemia
B. Chronic lymphocytic leukemia
C. Waldenstrom macroglobulinemia
D. Viral infection
B. Chronic lymphocytic leukemia
In which of the following is progression to acute leukemia least likely?
A. Chronic myelogenous leukemia (CML)
B. Refractory anemia with excess blasts (RAEB)
C. Refractoryanemiawithringed sideroblasts (RARS)
D. Chronic lymphocytic leukemia (CLL)
D. Chronic lymphocytic leukemia (CLL)
A Gaucher cell is best described as a macrophage with
A. “Wrinkled” cytoplasm due to an accumulation of glucocerebroside
B. “Foamy” cytoplasm filled with unmetabolized sphingomyelin
C. Pronounced vacuolization and deposits of cholesterol
D. Abundantcytoplasmcontaining storage iron and cellular remnants
A. “Wrinkled” cytoplasm due to an accumulation of glucocerebroside
Which of the following suggests a diagnosis of Hodgkin disease rather than other lymphoproliferative disorders?
A. Presence of a monoclonal population of large lymphoid cells
B. Predominance of immature B cells with irregular nuclear clefts
C. Circulating T cells with a convoluted, cerebriform nucleus
D. Presence of giant binucleated Reed-Sternberg cells with prominent nucleoli
D. Presence of giant binucleated Reed-Sternberg cells with prominent nucleoli
In a patient with fever of unknown origin, which of the following findings is not consistent with an inflammatory process?
A. Increased C-reactive protein
B. Increased albumin level
C. Increased fibrinogen level
D. Increased erythrocyte sedimentation rate
B. Increased albumin level
The presence of the chromosomal abnormality t(15;17) and a high incidence of disseminated intravascular coagulation (DIG) is diagnostic of
A. Acute myeloblastic leukemia without maturation (FAB type Ml)
B. Acute myeloblastic leukemia with maturation (FAB type M2)
C. Acute promyelocytic leukemia (FAB type M3)
D. Acute myelomonocytic leukemia (FAB type M4)
C. Acute promyelocytic leukemia (FAB type M3)