Leukocyte Diseases Flashcards
RBCs, eosinophils, neutrophils, basophils, monocytes, and platelets are subject to what kind of leukemia?
Myeloid leukemia
B and T lymphocytes are subject to what kind of leukemia?
Lymphoid leukemias
What is the lymphoid neoplasm of plasma cells called?
Multiple myeloma
What term is used when hematopoietic neoplastic cells are seen in the blood and/or bone marrow?
Leukemia
A blood smear on a sick dog shows a prominence of very immature cells with round nuclei containing nucleoli. What kind of leukemia is this and what’s the prognosis?
Acute leukemia. (Presence of blast cells and sick patient). Poor prognosis
The presence of mature neoplastic hematopoietic cells on a blood film indicates what kind of leukemia?
Chronic
A granulocytic leukemia affects what type of WBC?
neutrophils
A myelomonocytic leukemia affects what types of cells?
neutrophils and monocytes
How is a lymphoma different than a lymphoid leukemia?
In lymphomas, neoplastic lymphoid cells are associated with solid tumors OUTSIDE the bone marrow.
Neoplasms of which cells are formed from differentiated cells in the periphery, therefore are not considered hematopoietic neoplasms?
Mast cells and histiocytic cell precursors
What kind of leukemia is this?
Acute Lymphoblastic Leukemia
*Note large and pleomorphic nucleoli in the lymphoblasts
What kind of leukemia is this?
Acute Granulocytic Leukemia
*Note pronounced granules in the promyelocytes, and disorderly maturation of neutrophils
What kind of leukemia is this?
Acute Monocytic Leukemia
*Note nucleoli and indented nuclei in the monoblasts
What kind of leukemia is this?
Acute Erythroleukemia
*Note the navy blue cytoplasm and prominent nucleoli in the rubriblasts
Pelger-Huet anomaly, Mucopolysaccharoidosis, and Chediak-Higashi syndrome are all inherited abnormalities of what cell?
Neutrophils
On a blood film, you note that the mature neutrophil and eosinophil nuclei are hyposegmented. What is this anomaly called and how does it impact the function of the cells?
Pelger-Huet anomaly. Normal cell function.
The pictured neutrophils contain numerous dark purple or magenta granules, and the lymphocyte contains granules and vacuoles. What is this abnormality called and what causes it?
Mucopolysaccharoidosis
Caused by deficiency of lysosomal enzymes needed to degrade glycosaminoglycans (mucopolysaccharides).
A local breeder brings in his Persian kittens for exams before selling them. One of the kittens is smokey blue with yellow eyes. You check a blood smear, and just as you suspected, you find eosinophilic granules, indicating fused lysosomes, within the neutrophils. What disease is this and what problem should the breeder expect with this kitten?
Chediak-Higashi syndrome
This kitten will have a bleeding diathesis due to platelet dysfunction.
What’s up with this lymphocyte and with what type of disorder is this usually associated?
Cytoplasmic vacuolation
When inherited, usually associated with lysosomal storage disorders.
What is the general endpoint of lysosomal storage disorders?
Fatal neurologic disease
Muccopolysaccharoidosis, GM1 and GM2 gangliosidosis, Alpha mannosidosis, Neimann-Pick A B C, acid-lipase deficiency, and Fucosidosis are all inherited types of what disease?
Lysosomal Storage Diseases
Ingestion of this plant inhibits lysosomal enzymes, resulting in an acquired form of a lysosomal storage disease:
Swainsonine (locoweed)
