Leukocyte Diseases

Question 1

RBCs, eosinophils, neutrophils, basophils, monocytes, and platelets are subject to what kind of leukemia?

Answer 1

Myeloid leukemia

Question 2

B and T lymphocytes are subject to what kind of leukemia?

Answer 2

Lymphoid leukemias

Question 3

What is the lymphoid neoplasm of plasma cells called?

Answer 3

Multiple myeloma

Question 4

What term is used when hematopoietic neoplastic cells are seen in the blood and/or bone marrow?

Answer 4

Leukemia

Question 5

A blood smear on a sick dog shows a prominence of very immature cells with round nuclei containing nucleoli. What kind of leukemia is this and what’s the prognosis?

Answer 5

Acute leukemia. (Presence of blast cells and sick patient). Poor prognosis

Question 6

The presence of mature neoplastic hematopoietic cells on a blood film indicates what kind of leukemia?

Answer 6

Chronic

Question 7

A granulocytic leukemia affects what type of WBC?

Answer 7

neutrophils

Question 8

A myelomonocytic leukemia affects what types of cells?

Answer 8

neutrophils and monocytes

Question 9

How is a lymphoma different than a lymphoid leukemia?

Answer 9

In lymphomas, neoplastic lymphoid cells are associated with solid tumors OUTSIDE the bone marrow.

Question 10

Neoplasms of which cells are formed from differentiated cells in the periphery, therefore are not considered hematopoietic neoplasms?

Answer 10

Mast cells and histiocytic cell precursors

Question 11

What kind of leukemia is this?

Answer 11

Acute Lymphoblastic Leukemia

*Note large and pleomorphic nucleoli in the lymphoblasts

Question 12

What kind of leukemia is this?

Answer 12

Acute Granulocytic Leukemia

*Note pronounced granules in the promyelocytes, and disorderly maturation of neutrophils

Question 13

What kind of leukemia is this?

Answer 13

Acute Monocytic Leukemia

*Note nucleoli and indented nuclei in the monoblasts

Question 14

What kind of leukemia is this?

Answer 14

Acute Erythroleukemia

*Note the navy blue cytoplasm and prominent nucleoli in the rubriblasts

Question 15

Pelger-Huet anomaly, Mucopolysaccharoidosis, and Chediak-Higashi syndrome are all inherited abnormalities of what cell?

Answer 15

Neutrophils

Question 16

On a blood film, you note that the mature neutrophil and eosinophil nuclei are hyposegmented. What is this anomaly called and how does it impact the function of the cells?

Answer 16

Pelger-Huet anomaly. Normal cell function.

Question 17

The pictured neutrophils contain numerous dark purple or magenta granules, and the lymphocyte contains granules and vacuoles. What is this abnormality called and what causes it?

Answer 17

Mucopolysaccharoidosis

Caused by deficiency of lysosomal enzymes needed to degrade glycosaminoglycans (mucopolysaccharides).

Question 18

A local breeder brings in his Persian kittens for exams before selling them. One of the kittens is smokey blue with yellow eyes. You check a blood smear, and just as you suspected, you find eosinophilic granules, indicating fused lysosomes, within the neutrophils. What disease is this and what problem should the breeder expect with this kitten?

Answer 18

Chediak-Higashi syndrome

This kitten will have a bleeding diathesis due to platelet dysfunction.

Question 19

What’s up with this lymphocyte and with what type of disorder is this usually associated?

Answer 19

Cytoplasmic vacuolation

When inherited, usually associated with lysosomal storage disorders.

Question 20

What is the general endpoint of lysosomal storage disorders?

Answer 20

Fatal neurologic disease

Question 21

Muccopolysaccharoidosis, GM1 and GM2 gangliosidosis, Alpha mannosidosis, Neimann-Pick A B C, acid-lipase deficiency, and Fucosidosis are all inherited types of what disease?

Answer 21

Lysosomal Storage Diseases

Question 22

Ingestion of this plant inhibits lysosomal enzymes, resulting in an acquired form of a lysosomal storage disease:

Answer 22

Swainsonine (locoweed)