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HEMA: LEUKEMIA > LEUKEMIA > Flashcards

LEUKEMIA Flashcards

1
Q

Lymphocytic Leukemias are generally: Myeloperoxidase and Sudan Black B

A

Negative

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2
Q

Most common form of childhood leukemia

A

Acute Lymphocytic Leukemia

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3
Q

70% of childhood ALL

A

L1

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4
Q

Immunologic markers of L1:

A

CALLA (CD10)
TdT
CD19 AND CD20

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5
Q

(+) in PERIODIC ACID-SCHIFF and OIL RED O but (-) in Methylene green pyronine

A

L1

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6
Q

70% of adult ALL

A

L2

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7
Q

Immunologic marker of L2

A

TdT

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8
Q

(+) in PERIODIC ACID-SCHIFF AND OIL RED O but (-) in Methylene Pyronine

A

L2

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9
Q

Also known as Burkitt-type of Leukemia and it is rare in children and adult

A

L3

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10
Q

(+) in Methylene Green Pyronine and Oild Red O but (-) Periodic acid-schiff

A

L3

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11
Q

Characterize by persisten lymphocytosis and the presence of increased number of smudge cells and rieder cells in the PBS

A

Chronic Lymphocytic Leukemia

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12
Q

Most common type of leukemia in the elderly

A

Chronic lymphocytic leukemia

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13
Q

AML subgroup originates in myelocytic characterized by MPO and SBB negative

A

M0

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14
Q

AML without maturation, may demk auer rods

A

M1

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15
Q

AML with maturation, most common subtype of AML, may also demo auer rods

A

M2

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16
Q

Associated with DIC and presence of faggot cell also called Acute Promyelocytic Leulemia (APL)

17
Q

Aka Naegeli monocytic leukemia and Acute Myelomonocytic Leukemia, 2nd most subtype of AML

18
Q

Acute Monocytic Leukemia (AMoL) aka schilling leukemia

19
Q

AMoL poorly diff. Seen in children and 80% monoblasts in BM

20
Q

AMoL well diff. Seen in middle-aged adults, < 80 % monoblasts in BM

21
Q

Acute Erythroleukemia aka Diguglieimo’s syndrom. Associated with macrocytic, normochromic and (+) PASS

22
Q

Acute Megakaryocytic Leukemia that requires immunocytochemistry, (+) in factor VIII stain

23
Q

AMML with increased marrow eosinophils

24
Q

AML subgroups that originates in myelocytic

A

M0, M1, M2, M3,

25
Q

AML subgroup that originates in both myelocytic and monocytic

26
Q

AML subgroup that originates in monocytic

27
Q

AML subgroup that originates in megakaryocytic

28
Q

AML subgroup that originates in both erythrocytic and myelocytic

29
Q

AML subgroups positive in MPO, SBB AND SE

A

M1, M2, M3 and M4

30
Q

AML subgroup both positive in NSE (BUTYRATE), NSE (ACETATE)

31
Q

Factor stain VIII positive

32
Q

Characterized by the presence of philadelphia chromosome. Chromosome #22

A

Chronic myelogenous leukemia (CML) AKA chronic granulocytic leukemia

33
Q

Excessive leukocytic response in the peripheral blood

A

Leumoid Reaction

34
Q

Used to distinguised LR from CML

A

Leukocyte (Neutrophil) Alkaline Phosphate (LAP/NAP)

35
Q

Normal Kaplow’s (LAP) score

36
Q

Within normal or increased LAP score

37
Q

Decreased LAP score

HEMA: LEUKEMIA (5 decks)

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