LEUKEMIA

Question 1

Lymphocytic Leukemias are generally: Myeloperoxidase and Sudan Black B

Answer 1

Negative

Question 2

Most common form of childhood leukemia

Answer 2

Acute Lymphocytic Leukemia

Question 3

70% of childhood ALL

Answer 3

L1

Question 4

Immunologic markers of L1:

Answer 4

CALLA (CD10)
TdT
CD19 AND CD20

Question 5

(+) in PERIODIC ACID-SCHIFF and OIL RED O but (-) in Methylene green pyronine

Answer 5

L1

Question 6

70% of adult ALL

Answer 6

L2

Question 7

Immunologic marker of L2

Answer 7

TdT

Question 8

(+) in PERIODIC ACID-SCHIFF AND OIL RED O but (-) in Methylene Pyronine

Answer 8

L2

Question 9

Also known as Burkitt-type of Leukemia and it is rare in children and adult

Answer 9

L3

Question 10

(+) in Methylene Green Pyronine and Oild Red O but (-) Periodic acid-schiff

Answer 10

L3

Question 11

Characterize by persisten lymphocytosis and the presence of increased number of smudge cells and rieder cells in the PBS

Answer 11

Chronic Lymphocytic Leukemia

Question 12

Most common type of leukemia in the elderly

Answer 12

Chronic lymphocytic leukemia

Question 13

AML subgroup originates in myelocytic characterized by MPO and SBB negative

Answer 13

M0

Question 14

AML without maturation, may demk auer rods

Answer 14

M1

Question 15

AML with maturation, most common subtype of AML, may also demo auer rods

Answer 15

M2

Question 16

Associated with DIC and presence of faggot cell also called Acute Promyelocytic Leulemia (APL)

Answer 16

M3

Question 17

Aka Naegeli monocytic leukemia and Acute Myelomonocytic Leukemia, 2nd most subtype of AML

Answer 17

M4

Question 18

Acute Monocytic Leukemia (AMoL) aka schilling leukemia

Answer 18

M5

Question 19

AMoL poorly diff. Seen in children and 80% monoblasts in BM

Answer 19

M5a

Question 20

AMoL well diff. Seen in middle-aged adults, < 80 % monoblasts in BM

Answer 20

M5b

Question 21

Acute Erythroleukemia aka Diguglieimo’s syndrom. Associated with macrocytic, normochromic and (+) PASS

Answer 21

M6

Question 22

Acute Megakaryocytic Leukemia that requires immunocytochemistry, (+) in factor VIII stain

Answer 22

M7

Question 23

AMML with increased marrow eosinophils

Answer 23

M4E

Question 24

AML subgroups that originates in myelocytic

Answer 24

M0, M1, M2, M3,

Question 25

AML subgroup that originates in both myelocytic and monocytic

Answer 25

M4

Question 26

AML subgroup that originates in monocytic

Answer 26

M5

Question 27

AML subgroup that originates in megakaryocytic

Answer 27

M7

Question 28

AML subgroup that originates in both erythrocytic and myelocytic

Answer 28

M6

Question 29

AML subgroups positive in MPO, SBB AND SE

Answer 29

M1, M2, M3 and M4

Question 30

AML subgroup both positive in NSE (BUTYRATE), NSE (ACETATE)

Answer 30

M5

Question 31

Factor stain VIII positive

Answer 31

M7

Question 32

Characterized by the presence of philadelphia chromosome. Chromosome #22

Answer 32

Chronic myelogenous leukemia (CML) AKA chronic granulocytic leukemia

Question 33

Excessive leukocytic response in the peripheral blood

Answer 33

Leumoid Reaction

Question 34

Used to distinguised LR from CML

Answer 34

Leukocyte (Neutrophil) Alkaline Phosphate (LAP/NAP)

Question 35

Normal Kaplow’s (LAP) score

Answer 35

15 to 100

Question 36

Within normal or increased LAP score

Answer 36

LR

Question 37

Decreased LAP score

Answer 37

CML