Leukaemia

Question 1

leading cancer for age 15-24

Answer 1

lymphoma

Question 2

Most patients cause of leukaemia?

Answer 2

unknown

Question 3

Leukaemia usually starts with which cells?

Answer 3

pluripotent progenitor cells

Question 4

Leukaemia mutations generally from?

Answer 4

chromosomal translocation

Question 5

fusion genes do what?

Answer 5

disrupts normal cells and predisposes to malignant transformation

Question 6

Acute Leukaemia what kind of cells? clinical course?

Answer 6

immature cells, rapid clinical course

Question 7

chronic Leukaemia cell type? clinical course?

Answer 7

maturer white cells, gradual course, treatment optional

Question 8

how would acute Leukaemia kill you

Answer 8

block out capillaries and oxygenation

Question 9

2 kinds of Leukaemia

Answer 9

lymphoblastic - T and B-cells

myeloblastic - RBCs, platelets, mono, granulocytes

Question 10

what is thrombocytopenic pupura?

Answer 10

burst capillaries due decreased platelets

Question 11

Chronic lymphocytic leukaemia cells looks like on slide?

Answer 11

mature, increased numbers, smear cells

Question 12

flow cytometry used for?

Answer 12

dx markers on lymphocytes to characterize the disease

Question 13

Chronic lymphocytic leukaemia, you don’t see on slide 2 things:

Answer 13

1. granules

2. Auer Rods

Question 14

Acute lymphocytic leukaemia you see on slide? 3 things

Answer 14

1. blastic cells
2. granules
3. Auer Rods

Question 15

Hairy Cell leukaemia is acute or chronic?

Answer 15

chronic, good Rx

Question 16

Chronic myeloblastic leukaemia see what kind of shift?

Answer 16

left shift

Question 17

acute myeloblastic leukaemia see what in the cell?

Answer 17

+++ Auer Rods

Question 18

chromosome 15-17 translocation of which 2 regions?

Answer 18

RAR-Alpha and PNL fusion

Question 19

Philedelphia chromosome which translocation?

Answer 19

9 and 22

Question 20

what is imatinib? does what?

Answer 20

monoclonal antibody

inhibits the BCR-ABL to induce apoptosis, inhibit proliferation

Question 21

All Gene fusions cause problems? what are the classes?

Answer 21

1. Driver mutations
2. passenger mutations
3. which are pathogenic?

Question 22

Acute Myeloid leukaemia genomic and epigenomics contribution?

Answer 22

complex interplay

Question 23

CLL pro-survival protein is?

Answer 23

BCL-2

Question 24

what is ABT-199?

Answer 24

selective BCL-2 inhibitor for CLL

Question 25

when mainly observe patient?

Answer 25

CLL

Question 26

transplantation for leukaemia first line?

Answer 26

autologous then allograft if necessary

Question 27

3 sources of autologous transplantation for leukaemia?

Answer 27

1. peripheral blood
2. bone marrow
3. cord blood

Question 28

Survival of leukaemias?
Childhood ALL:
Adult AML/ALL:
CML:
CLL:

Answer 28

Childhood ALL: 80%
Adult AML/ALL: 20-40%
CML: 80-90%
CLL: 5-10 year

Question 29

Leading Cancer for 0-14 year olds?

Answer 29

Leukaemia