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Hemato > Leucemia mielóide crónica > Flashcards

Leucemia mielóide crónica Flashcards

1
Q

Mutação/proteína envolvidas em 90% da LMC?

A

t(9;22) proteína BCR(22) ABL (9)

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2
Q

Fases da história natural da LMC?

A
  1. Fase indolente ou crónica
  2. Fase acelerada
  3. Fase blástica terminal
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3
Q

Sintomas mais comuns da LMC?

A

Anemia e esplenomegalia

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4
Q

Critérios de fase blastica na LMC?

A
  • > = 30% blastos no sangue ou medula óssea
    OU
  • lençóis de blastos na doença extramedular
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5
Q

Objectivo da terapêutica na LMC?

A

Alcançar e manter uma resposta citogenica completa

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6
Q

Taxa de sobrevivência de LMC pôs terapêutica com TKI?

A

85% aos 10 anos

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Hemato (19 decks)

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