Leucemia Linfocitica Cronica Flashcards

1
Q

Fr para leucemia linfocitica cronica?

A

Antecedentes familiares, radiacion, solventes, benceno

Edad >60-70 años

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2
Q

Inmunofenotipo de a cuerdo a la esterpe celular T y B?

A

linfocitos T: cd3, cd4, cd7

Linfocitis B: cd>10

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3
Q

Clinica clasica de la LLC?

A

Linfadenopatia
Hepatoesplenomegalia
Linfocitosis (>5,000 en 3 meses)
Otros: perdida de peso, anemia, trombocitopenia

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4
Q

Que se observa en un aspirado de medula osea en la LLC?

A

> 30% linfocitos madulos (no blastos)

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5
Q

Afectacion cromosomica en LLC?

A

Cromosoma 13

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6
Q

Clasificaciones usadas en LLC?

A

Rai: y Binet
Binet: ABC

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7
Q

Cuando se otorga tratamiento?

A

Cuando presente sintomas de anemia, trombocitopenia es decir Rai III o Binet C

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8
Q

Que es el sindrome de Richter?

A

Es el paso de una LLC a LNH

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9
Q

Tratamiento de la LLC?

A

FCR
Fludarabina
Ciclofosfamida
Rituximab (si cd20)

> 60 años y comorbidos= clorambucilo

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10
Q

Porcentaje de blastos en medula para considerar leucemias agudas?

A

> 20% blastos= LMA

>30% blastos= LLA

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