Lesson 5: Protein Folding Flashcards
What does the primary structure of a protein determine ?
It determines how a protein will fold
Why is the primary structure formed ?
Due to the peptide bonding
What are the 2 examples of chaperones ?
hsp70 and hsp60
What do the 2 chaperons we learned stop ?
The aggregation of proteins
What causes Alzeheimer’s ?
Accumalation of B-amyloid
solube aplha rich state –> insoluble B-rich state
Which structures can renature ?
Secondary, Tertiary, Quaternary,
What structure is the protein first biologically active ?
Tertiary
What determines the tertiary strcutre of proteins ?
the interactions between the functional groups of side chains
disulfide bond, h-bond, hydrophobic interactions, salt-bridge
What are domains ?
Parts of the protein that serve a specific function
What determines the Quaternary structure ?
The covalent and non covalent interactions between subunit surfaces
T/F: Hemoglobin is a dimeric protein.
False, Tetrameric
What happens to the solubility and viscosity of a denatured protein ?
Solubility decreases and viscosity increases
What does the quaternary structure define ?
The number&type of polypeptide & their spatial arrangment
What determines the secondary structure ?
The H-bond interactions
How many amino acid residues are found per turn of helix ?
3.6
