Lesson 2/Chapter 2 Flashcards
Nutrients for homeostasis, repair and regeneration:
water, protein, carbs, fats, vitamins, minerals
Dehydration:
1% decrease in body weight due to fluid loss
Patients on air-fluidized beds require:
40-60mL of water/kg BW daily
When would a patient need a dietician referral?
swallowing difficulties, fluid restrictions, NPO more than a few days
Average amount of water per kg of body weight?
30–35 mL
- 7–3.7 l/day average
- 5L/day minimum
What is protein required for?
Collagen synthesis Granulation tissue formation Angiogenesis Remodeling Immune function
What does a protein deficiency alter?
osmotic pressure, causing edema
What percentage of protein is nitrogen?
16%
Positive nitrogen balance needed to enhance wound healing
How much of protein is need daily?
1.25–1.5 g protein/kg BW daily
Marasmus
protein deficiency though deprivation or impaired absorption, significant weight loss, caused by CA & COPD
Kwashiorkor
decreased albumin causes swelling, spares muscle, decreased immunity, infection, skin breakdown and pressure ulcers common
Marasmus Kwashiorkor-
combined- high risk of mortality & morbidity
Amount of protein needed for tissue repair?
½ body weight in pounds or 1.25-1.5g/kg of body weight for stage III & IV ulcers
Specific amino acids:
glutamine
arginine
hydroxy-methylbutyrate (HMB)
Glutamine
most abundant (20%) fuel source for small cells, primary fuel source for lymphocyte proliferation, precursor for nucleotide production in fibroblasts and macrophages, stimulates inflammatory response in wound healing, levels fall in plasma and muscle after trauma
Arginine
semi-essential amino acid, decreased production in times of stress and injury, primary component in wound healing, increases collagen deposition, fibroblastic activity, and immune function
Hydroxy-methylbutyrate (HMB)
helps support immune function, helps decrease muscle breakdown, need to give with arginine & glutamine
Carbohydrates
Primarily in the form of glucose
Provide energy for tissue repair and regeneration
Protein-sparing effect
Carbs in BW daily?
30-35kcal/kg
20-30% of total calories
What do fats do?
Provide a needed energy source when carbohydrates have been depleted
Carry fat-soluble vitamins
Assist with thermoregulation
What do free fatty acids do?
Vital components of cell membranes
Required for synthesis of new cells
What does too much fat cause?
immunosuppression
What do fat deficiencies cause?
decreased production of phospholipids which are part of the basement membrane and decrease prostaglandin production
What does omega-3 have in it?
anti-inflammatory effect, inhibit PDFG, IL-1 & TNF-alpha, may weaken wounds by impairing cross-links and collagen alignment
Fat-soluble vitamins
A,E,K
Water-soluble vitamins
C
B-complex
Vitamin A (retinol)
Maintains healthy skin and mucous membranes
Required for collagen synthesis, promotes granulation tissue formation, and facilitates epithelialization
May reverse inhibitory effects of corticosteroids
What can Vitamin A increase?
wound tensile strength
Increases inflammatory response
Increases EGF-(epidermal growth factor) increases collagen synthesis
Vitamin C (ascorbic acid)
Builds and maintains tissues
Helps body absorb iron
May help control infections and limit damaging effects of free radicals
May enhance wound healing in malnourished patients and patients with pressure ulcers
Pretreatment of irradiated skin with Vitamin C may limit skin damage
What is vitamin C essential for?
collagen synthesis
deficiency delays would healing
RDA of vitamin C
60mg/day
Vitamin K
Fat-soluble vitamin
Essential for blood clotting
Deficiency may lengthen the inflammatory phase
If on anticoagulant, do not supplement without MD clearance
B-Complex Vitamins
Group of eight vitamins
Required for normal immune function and energy metabolism
Aid in white blood cell function, antibody formation, and resistance to infection
Facilitates fibroblast function, collagen synthesis
Important co-enzymes
Vitamin B6
for protein and hemoglobin synthesis. Rec-.4mg
Vitamin B12:
Prevents anemia. Rec- 2mg
Vitamin E
Helps prevent free radical–related cellular damage
Decreases inflammatory phase of wound healing
Enhances immune function
Decreases platelet adhesion
What can vitamin E adversely affect?
wound healing and decrease collagen production, may weaken wounds
Microminerals:
iron
zinc
copper
magnesium
Macrominerals
calcium
phosphorus
selenium
How much zinc does the skin contain?
Skin contains 20% of the body’s zinc stores