Lesson 2 Flashcards
Reversible process between drugs and protein carrier
Distribution
Irreversible loss drug in the body
Elimination
Eliminate 1 that is not included in factors that influence drug metabolism
1. Age
2. Tissue depo
3. Genetic factor
4. Change in metabolism rate ( Enzyme induction and Enzyme inhibitor)
2
Drug + Receptor + Intrinsic activity
= Agonist
Drug+p + Receptor + No intrinsic activity
Antagonist
What is idiosyncrinsy
Unusual response to drug
Measurement of drugs in lne with safety
Therapeutic Index
Concurrent to produce effect
Potency
Maximal response
Efficacy
Combination of drugs
Seniment
Eliminate 1 that is not included in Mechanism of drug action
1. Interaction with receptor
2. Interaction with Enzyme
3. Interaction with membrane phase
4. Interaction with DNA and RNA
5. Inhibition of ChOn (protein)
6. Interaction with cell membrane
3
Effect of medication that is not in medication
Placebo effect
1 + 1 = 2
Addition
1 + 1 = 3 or more
Synergism
0 + 1 = 2 or more
Potentations