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Pharmacology > Lesson 1 > Flashcards

Lesson 1 Flashcards

1
Q

Pharmacology

A

Study of drugs in prevention, treatment, and diagnosis

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2
Q

What is PPD

A

Purified protein derivatives

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3
Q

Pharmacodynamic

A

Psychological effects of drugs and mechanism of action

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4
Q

What is GAMUT?

A

G- Ginhawa (Symptoms)
A- Alisin ang sanhi (Curative)
M- Maibalik sa dati (Restoration)
U- Umiwas (Prevention)
T- Tukuyin ang sanhi (Diagnosis)

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5
Q

Pharmacokinetics

A

ADME
Time required for drug concentration to develop or change

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6
Q

Pharmacotherapeutic

A

How drugs best use for treatment

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7
Q

Pharmacognosy

A

Study lf drugs derived from herbal and other natural sources

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8
Q

Bioavailability

A

Ability of drug to be absorb and use by the body
Rate and extent of systemic absorption

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9
Q

Bioequivalence

A

Similarity of drug that share the same ingridients and desired outcome

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10
Q

Empirical doses

A

Medication without knowing the cause

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11
Q

What is BBB

A

Blood brain barrier

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12
Q

What are the determination of absorption?

A

Disintegration - breakdown of tablet into small particles
Dissolution - Will dissolve in small particles in GI fluid
Diffusion

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13
Q

Liquid form

A

No need to undergo determination of absorption

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14
Q

80% of drugs is taken through what?

A

By mouth or orally

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15
Q

Rate limiting

A

Delay that restricts the speed of the whole process

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16
Q

Is drugs or medication that is in solid form a 100% medicine?

A

No

17
Q

What is fillerd and additives?

A

Filler - Prepare tye medication, changes size and shape.
Additives - for better absorption (Na and K Salts)

18
Q

Decreased in gastric pH will results to?

A

Increased in gastric acid and poor absorption

19
Q

What form of medicine has fast absorption?

A

Liquid form

20
Q

pH 1-2

A

Acidic
Higher acidity
Higher absorption

21
Q

pH 7.4

A

Normal blood pH

22
Q

Sensitive in acidic environment

A

Red Blood Cells (RBC)

23
Q

What is lysis

A

destruction of RBC when exposed to acidic environment

24
Q

What is enterecoted medicine

A

Medication that has special coating protecting the medicine to be dissolve in gastric environment or acidic environment.
There is a delay.
Should be absorb in small intestine
DO NOT CRUSHED

25
Q

Passive absorption

A

Movement of minerals to cell/tissue without the use of energy

26
Q

Active absorption

A

Requires a carrier ( proteins ) to move the drugs and requires energy.
Higher to lower concentration.

27
Q

O2 + Glucose

A

ATP

28
Q

What will happen without ATP?

A

Pyrobate is produce.
Convert to lactate
Convert to lactic acid
Destroy absorption kf drugs
Bioavailability is destroy.

29
Q

What is Pinocytosis?

A

Cell drinking

30
Q

Pharmacokinetics phase of Membrane is compose of?

A

Fat and protein and is embedded in lipid bilayer

31
Q

What are the 2 layer of phospolipid molecules

A

Inner - hydrophobic fatt acid tails
Outer - Hydrophilic polar heads

32
Q

What is lipid soluble drugs

A

Pass rapidly to membrane called lipophilic drugs

33
Q

What is water soluble drugs

A

It requires energy (enzyme and proteins)

34
Q

What is hepatic first pass and explain

A

Process where drugs pass through first and concentration of drugs is reduce before going to systemic circulation.

Stomach - Intestinal Lument - Portal vein - Liver

  1. Liver dysfunctional
  2. Less hepatic blood flow
  3. Less drug metabolism
  4. Less convertion of drug to inactive form
  5. Increase of bioavailability
  6. Increase of drug concentration
  7. Increase of drug accumulation
  8. Increase of drug toxicity
  9. Death
35
Q

What will happen in rapid absorption?

A

Increase dug concentration and increase drug toxicity.

36
Q

What will happen in slow absorption?

A

Limited bioavailability
Decreased serum concentration
Need high dose.

Pharmacology (4 decks)

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