Lesson 1 to Lesson 2a Flashcards
a commensal in the rumen but can cause hepatic abscesses if transferred to the liver of feedlot cattle
Fusobacterium necrophorum
relative capacity of a pathogen to damage a host
virulence
commensals living in skin or mucous membranes take advantage of impaired antimicrobial defenses of the hosts and behave as opportunistic pathogens
endogenous infections
main portals of entry of pathogens
mucosae of GI, respiratory, and urogenital tracts
often resistant to phagocytosis
encapsulated bacteria
binding of complement and antibody to the bacterial surface
opsonization
capsule of Bacillus anthracis
polyglutamic acid
produced and secreted by viable bacteria
exotoxins
integral constituents of the bacterial cell wall not released until the microorganms are lysed
endotoxins
where does toxicity reside in a gram negtive bacteria?
Lipid A portion (hydrophobic glycolipid)
bacteria with A-B subunit structure
tetanus toxin, botulinum toxin
detects conserved molecular patterns unique to microorganisms not expressed by the hosts
Pattern recognition receptors
Mammals possess a family of transmembrane PRR called as?
Toll-like receptors
microbial patterns which recognize LPS, lipoteichoic acid, DNA from bacteria, glucans from fungi
Pathogen-associated molecular patterns
it detect molecular signatures of microbial pathogens and orchestrate the innate immune response to help initiate adaptive immune response
TLRs
host wherein pathogens are sequestered in a specific organ such as gall bladder or lymph nodes and not exreted in the feces
latent carrier
pathogen is shed in the feces
active carrier
adhere to epithelial cells of small intestines in newborn animals which are not invase but induce diarrhoea
ETEC