Lesson 1: Introduction to memory and neurobiology Flashcards

1
Q

What is memory?

A

location where information is kept; engram/trace - each memory is mental process used for different mental representation; used to acquire, store or retrieve information

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2
Q

What is learning?

A

any change in the potential of people to alter their behavior as a consequence of the experience of regularities in the environment

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3
Q

What is memory diagram?

A

Learning → Storage of information → Retention (Consolidation, generalization, distortion, forgetting) → Retrieval based on cue → Remembering (or not)

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4
Q

How did Aristotle contribute to memory research?

A

he studied associations between stimuli or experiences

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5
Q

How did Romans contribute to memory research?

A

They developed method of loci (organizing memory in space, creating sort of the mental map); also used in medieval times by monks

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6
Q

How did Charles Darwin contribute to memory research?

A

He investigated evolutionary aspects of memory in survival. He argued that memory evolved to capture environmental characteristics.

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7
Q

How did Randolf Menzel contribute to memory research?

A

He researched bees and observed that they have different types of memories -> similarily to humans he distinguished short term, middle type and 2 types of long term memory. The conclusion is that different memory stages contribute to survival of bees

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8
Q

How did Hermann Ebbinghaus contribute to memory research?

A

He studied memory in its ‘‘purest form’’ in absence of prior knowledge. To do that, he developed nonsense syllable. He developed learning curve (period of time necessary for memorization of information) and forgetting curve. Moreover, he discovered idea of distributed practice and concept of savings.

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9
Q

What are savings?

A

after seemingly forgetting learned information, it is still easier to re-learn this information

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10
Q

How can forgetting be delayed indefinately (in theory)?

A

by process of overlearning when people continue to learn until perfect recall is achieved

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11
Q

How did Adolf Jost contribute to memory research?

A

He developed Jost’s Law - - if two memory traces have equal retrieval probability, but different ages, the older one will:
- a) be forgotten more slowly than the younger one
- b) benefit more from additional learning

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12
Q

How did Francis Bartlett contribute to memory research?

A

He postulated that we don’t remember in vacuum and undermined importance of context. He focused on the concept of reconstructive memory - memory are fragmentary or incomplete, therefore people fill them out with prior knowledge

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13
Q

How did William James contribute to memory research?

A

He distinguished between primary (short-term) and secondary (long-term) memory. He thought of tip-of-the-tongue phenomenon

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14
Q

How did Sigmund Freud contribute to memory research?

A

He put emphasis on unconscious processes. He thought that repression is mechanism of forgetting. He thought of slip-of-the-tongue phenomenon.

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15
Q

How did Lasley contribute to memory research?

A

He wanted to check if it is possible to locate individual memories in the brain. He used rats and surgically removed parts of their brains. He found that the bigger the lesion, the worse memory performance (however, this was found regardless of where lesion was performed)

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16
Q

How did Theodule Ribot contribute to memory research?

A

He postulated ‘‘Ribot gradient’’ - more recent memories are also more vulnerable and more likely to be impaired in case of brain lesion

17
Q

How did Donald O. Hebb contribute to memory research?

A

He focused on neural networks (Hebbian learning). Associated with notion ‘’cells that fire together wire together’’

18
Q

What influenced cognitive psychology in the 50s?

A

Milner’s law of 7+/-2 of short term memory capacity made people thing about analogy to computers with limited processing abilities. People started comparing RAM to short term memory and hard disk to long-term memory. Moreover, Shannon and Weaver defined concept of bit (smallest unit of infomration)

19
Q

What is Broadbent’s model of memory?

A

Information comes through senses and approaches selective filter (to avoid infomation overload). Only limited number of information enters short-term memory store. Importance of attention!

20
Q

What is Atkinson and Shiffrin model?

A

Sensory input gets to sensory store and remains there up to 3 seconds. Only via attention, information can enter short-term or working store where unrehearsed information is lost after 15 seconds. Therefore, rehearsal is crucial to maintain information in working memory store. Then upon encoding, information can enter long-term memory store/

21
Q

What is Baddeley and Hitch model?

A

It describes working memory system as comprised of different subcomponents -> Visuospatial Sketchpad, Episodic Buffer, Phonological Loop and Central Executive

22
Q

What is Tulving memory model?

A

Called triarchic theory of memory, it focuses on 3 memory types - nondeclerative memory, episodic memory and semantic memory

23
Q

Is memory location-specific?

A

No, memory is emergent property of nervous system - it emerges by neurons working together. It was shown by Penifield who stimulated memory-unrelated brain areas and unexpectedly caused specific memories retrieval.

24
Q

How is Hebbain learning related to memory?

A

Relearning causes synapses to grow even bigger

25
Q

How are spine fluctuations related to memory?

A

Spine fluctuations are common throughout the day - stronger fluctuations for smaller spines, lower fluctuations for bigger spines. Long term memory are thought to be stored in bigger synapses (which fluctuate less)

26
Q

Why is hippocampus important?

A

It is crucial for foming new memories. Moreover, it is specialized in spatial memory (shows grid signal)

27
Q

How are hippocampal lesions studied in rats?

A

With the use of Morris Water Maze. In this paradigm, rats need to swim and find escape platform. As the water is NOT translucent, animals need to memorize the platform position. Mice with hippocampal lesion cannot learn how to find the platform IF they are placed in different spots. If mice are placed in the same spot each time, they can use striatum to form habit and find platform (no need for hippocampus)

28
Q

What are parahippocampal areas?

A

Parahippocampal cortex is important for forming complex associations and episodic memory. Perihinal cortex is important for feelings - especially familiarity.

29
Q

What happens to monkeys with parahippocampal lesions?

A

They struggle in nonmatching trials where the reward comes with different object (not the one previously learned). They cannot learn new association.

30
Q

What are direct connections?

A

Those are cortico-cortical connections which serve to hold old memories. Lesions of hippocampus don’t affect them.

30
Q

Why acetylcholine (produced in basal forebrain) is important?

A

Because it aids new memory formation. Its production goes down in Alzheimer’s disease

31
Q

What happens in Alzheimer’s disease?

A

The hippocampus gets de-attached from the rest of the brain (new memories formation affected). Production of acetylcholine goes down.

32
Q

Why we make distinction between episodic and semantic memory?

A

Because there are two different types of dementia: semantic dementia (meaning of things disappears) and Alzheimer’s dementia (new memory formation is impossible)

33
Q

Why we make distinction between explicit and implicit memories?

A

Because of anterograde amnesia (bilateral hippocampal lesion) - in this condition, forming new memories is impossible, but patients still can learn new actions (implicit memory intact)

34
Q

Why synaptic consolidation is important?

A

It is crucial for creation of enduring memories. Wider consolidation occurs in larger brain systems which enables long-term memories to become more independent from hippocampus.