LES Flashcards

1
Q

Anticorpo da nefrite lupica
2o mais especifico
Marca atv de doença

A

Anti- DNA dupla helice (nativo)

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2
Q

Anticorpo do LES farmaco induzido

A

Anti - histona

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3
Q

Anticorpos do Anti-ENA

A

Anti-Ro
Anti-La
Anti-RNP
Anti-Sm

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4
Q

Anticorpo mais especifico do LES

A

Anti-Sm

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5
Q

Anticorpo relacionado a doenca mista do tecido conjuntivo

A

Anti-RNP

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6
Q

Anticorpo relacionado a Sd de Sjogren e geralmente qnd aparece nao tem nefrite,

A

Anti- La (= anti SSB)

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7
Q

Anticorpo relacionado a Sd de Sjogre, ao LES neonatal, ao LES FAN negativo, a fotossensibilidade e ao LES cutaneo subagudo

A

Anti-Ro

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8
Q

Anticorpo anti citoplasmatico

Relacionado a psicose lupica

A

Anti-P

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9
Q

Anticorpos anti-membrana

A
Antilinfocito
Antineuronio
Antiplaqueta
Anti-hemacea
Antifosfolipideos (provocam trombose)
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10
Q

Anticorpos antifosfolipideos

A

Anticoagulante lupico
Anti beta2 glicoproteina
Anticardiolipina

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11
Q

Os 11 criterios diagnosticos de LES

A

1) rash malar
2) fotossensibilidade
3) lupus discoide
4) ulceras orais

5) artrite nao erosiva de 2 ou + articulações

6) serosite: pleurite ou derrame pleural ou pericardite ou derrame pericardico
* qnd so acomete serosas é LES brando (ex: LES farmacoinduzido)

7) “penias”: 
anemia hemolítica (ret>3%), 
leucopenia <4000 (2 medidas), 
linfopenia <1500 (2 medidas), 
plaquetopenia <100000 (melhor p olhar)
*qnd vai ate as penias é LES moderado

8) proteinuria >= 500 mg/d
>= 3+ no EAS
Cilindros celulares

9) neurologico: convulsões ou psicoses inexplicadas por outro motivo
* qnd chega ate aqui é LES grave

10) FAN+
11) anti DNA ou anti Sm ou antifosfolipídeo

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12
Q

Tto LES cutaneo-articular

A

Protetor solar/ antimalaricos/ AINE

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13
Q

Tto serosite LES

A

Prednisona 0,5 mg/kg/dia

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14
Q

Tto LES hematologico e SNC

A

Prednisona 1 mg/kg/dia +/- imuno

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15
Q

Tto nefrite lupica

A

Classe 4 (proliferativa difusa): ciclofosfamida + corticoide

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