Lectures 9 & 10 - Somatic Motor System Flashcards
What does the somatic motor system control?
Skeletal muscle
Where do our lower motor neurons emanate from?
- Ventral horns of the spinal cord
2. Brainstem
What are the 3 sources of input for LMNs? What is this called?
- Spinal interneurons
- Sensory neurons from muscle spindles
- Upper motor neurons in the brain
Final Common Pathway
What are the 2 types of lower motor neurons? What does each innervate?
- Alpha: extrafusal muscle fibers
2. Gamma : intrafusal muscle fibers
What is the function of gamma motor neurons?
Gain function in motor reflexes
What is another name for a myotatic reflex?
Stretch reflex
What motor neurons do myotatic reflexes involve?
Both alpha and gamma
Describe the 4 steps of a myotatic stretch.
- Perception of stretch of intrafusal muscle fibers by muscle spindle
- Afferent signal sent through Ia sensory axons to spinal chord
- Ia sensory neurons synapse with homonymous alpha motor neurons and inhibitory interneurons for the antagonist muscle at the ventral horn
- Alpha motor neurons secrete ACh to cause contraction of the extrafusal muscle fiber
What is the role of the gamma motor neurons in myotatic reflexes?
TBD
What kind of neurons are LMNs? Purpose?
Multipolar
It receives input from several different sources
What does a motor unit consist of? What kind of property is this?
Alpha motor neuron + all of the muscle fibers it innervates
Divergent property
What does a motor neuron pool consist of?
What kind of property is this?
All of the alpha motor neuron innervating a particular muscle
Convergent property
According to which 2 characteristics do we classify motor units?
- Size = power (contractile force)
2. Type of muscle fiber: red or white
What are the 2 types of motor units classified by size? Describe each
- Small = small alpha motor neuron + small diameter muscle fibers = low contractile force
- Large = large alpha motor neuron + large diameter muscle fibers = high contractile force
What are the 2 types of motor units classified by type? Describe each
- Red: slow twitch due to slow myosin ATPase and low fatigability due to oxidative metabolism
- White: fast twitch due to fast myosin ATPase and high fatigability due to glycolytic metabolism
How does the size of a motor unit affect its EPSP threshold? What does this mean?
Larger motor units have a higher EPSP threshold, meaning they contract with more APs than smaller motor units
What 5 characteristics of alpha motor neurons INCREASE with increased motor unit size?
- Cell body size
- Dendritic complexity
- Short-term EPSP potentiation with repeated activation
- Axonal diameter
- Number of axonal branches
What 5 characteristics of alpha motor units DECREASE with increased motor unit size?
- Input resistance
- Excitability
- Ia EPSP amplitude
- PSP decay constant
- Duration of after-hyperpolarization
Do motor units exhibit plasticity?
YUP
What particular experience shows that motor units have plasticity?
- Soleus muscle involved in postural control: longer time for motor unit to peak (red fiber) and long duration
- Gastrocnemius muscle involved in fast movement: shorter time for motor unit to peak (white fiber) and short duration
However, when chronically stimulating a gastroscnemius muscle, it learns to take longer to peak and last longer: can use oxidative phosphorylation
What does the after-hyperpolarization of a neuron refer to?
The undershoot phase
How does training affect motor units?
- Increase firing rate
2. Increase torque
What are the 3 types of motor units based on both size and muscle fiber type?
Characteristics for each:
- Size/diameter?
- Strength?
- Type?
- Mito?
- Capillaries?
- Mb?
- ATP synthesis main pathway?
- Main function?
- Slow motor units: small, weak, red fibers, many mito, many capillaries, high Mb, oxidative phosphorylation, and are used for sustained contractions (eg: posture)
- Fast fatigable motor units: large, strong, white, few mito, few capillaries, low Mb, glycolysis, and used for sprints, jumping and other fast movements
- Fast contracting fatigue-resistant motor units: medium size and force, red/pink so fatigue resistant (intermediate rate of fatigue) AND fast contracting, many mito, many capillaries, high Mb, oxidative phosphorylation
What are the 3 factors regulating contractile force of a motor unit?
- LMN firing rate
- % of active motor units
- Size of active motor units
What type of motor units for walking?
Fast contracting fatigue-resistant motor units
What is the size principle?
Recruitment of motor units increases the force available
How are motor neuron pools organized in the spinal cord?
- Axial, proximal, and flexor muscle control is closer to central canal
- Distal and extensor muscle control is closer to the ventral horns
Where are LMN that control proximal and distal muscles mainly found in the spinal cord?
Cervical and lumbosacral spinal cords
Where are LMN that control axial muscles mainly found in the spinal cord?
Thoracic spinal cord
What does the organization of motor pools allows us to predict?
Weakness from location of ventral horn injury and vice versa
How have we been able to figure out motor neuron pools organized in the spinal cord?
Dye injected in muscle will travel back to the spinal cord and dye the area of the grey matter that controls it
What are the 2 types of spinal reflex pathways? Explain each
- Monosynaptic pathway: no interneuron
2. Polysynaptic pathway: interneuron involved
What is an example of a polysynaptic reflex pathway?
Pain withdrawal reflex
What is an example of a monosynaptic reflex pathway?
Patellar tendon reflex
What is the definition of a reflex?
Communication between afferent and efferent pathways that do not require conscious thought
What is the basic explanation of a myotatic reflex?
Pull on a muscle, it will contract to pull back
Is the myotatic reflex considered monosynaptic or polysynaptic? What to note?
Monosynaptic
However the inhibition of the antagonist muscle does involve an inhibitory interneuron
What are muscle spindles?
Sensory receptors on the intrafusal fibers within the belly of a muscle that primarily detect changes in the length of this muscle
How does the muscle spindle affect the rate of firing of the Ia afferent neuron?
Relaxed: low firing frequency
Stretched: high frequency of firing
How does the firing of the Ia afferent neuron due to muscle spindle stretching evolve over time?
It dissipates over time
How does the reverse myotatic reflex function? Explain how it works.
Opposes contraction
Golgi tendon organ (nerve endings connecting muscle and tendons) sends information via the Ib afferent neuron which synapses with an inhibitory interneuron in the spinal cord to oppose contraction when you lift something that is too heavy for you
Activity of muscle spindle and Golgi tendon when the muscle is passively stretched?
- Muscle spindle: high firing of Ia afferent neuron
2. Golgi tendon: low firing of Ib afferent neuron
Activity of muscle spindle and Golgi tendon when the muscle is actively contracted?
- Muscle spindle: low firing of Ia afferent neuron
2. Golgi tendon: high firing of Ib afferent neuron
What is the cross extension reflex?
Reflex that provides structural support during a flexion reflex of the opposite leg
What function of somatic control does the basal gaglia have?
Initiation
What function of somatic control does the association cortex have?
Planning
What function of somatic control does the cerebellum have?
Coordination and refinement
Compare damage to UMNs and LMNs.
- UMNs: increased muscle tone, decreased strength, increased stretch reflexes (hypereflexia), and moderate atrophy
- LMNs: decreased muscle tone, decreased stretch reflexes (hyporeflexia), pronounced weakness, and severe atrophy
What are the 3 brain structures involved in somatic control that send information to the UMNs? Which ones first send information to the thalamus?
- Basal ganglia**
- Association cortex
- Ceberellum**
What are the 6 signs/symptoms of LMN damage?
- Paresis
- Flaccid paralysis
- Hyporeflexia
- Visible fasciculations
- Fibrillations (non-visible)
- Muscle atrophy
What is paresis?
Weakness
What are fasciculations?
Pathological spontaneous depolarizations of single LMNs in a motor unit due to sick but not yet dead LMNs
How are muscle fibrillations detected?
EMG = Electromyography
What are muscle fibrillations?
Pathological spontaneous depolarizations of individual muscle fibers with dead or absent LMNs
What does the lateral white matter of the spinal cord contain?
Axons from the motor cortex
What does the medial white matter of the spinal cord contain?
Axons from the brainstem
Do UMN of the cerebral cortex cross the midline?
YUP
What do UMNs from the cerebral cortex control? Describe the pathway.
Lateral white matter UMNs => LMNs in the lateral ventral horn => distal muscles
What are distal limb muscles used for?
Skilled movements
What do UMNs from the brainstem control? Describe the pathway.
Medial white matter UMNs => LMNs in the medial ventral horn => axial, proximal, and flexor muscles
What are axial and proximal limb muscles used for?
Posture and balance
What is a Brodmann’s area?
Area of the cerebral cortex
What does the central sulcus of the brain divide?
Pre and post central gyrus
How do cortical UMNs communicate with the rest of the body?
Descending axons that form pyramidal tracts:
- Corticospinal tract
- Corticobulbar tract
What does the Brodmann area 6 include? Where is it located?
Secondary motor cortex:
- Premotor area
- Supplementary motor area
Rostral to Area 4
What does the Brodmann area 4 include? Where is it located?
The primary motor cortex
Between area 6 and the central sulcus
What are Betz cells? Where are they found?
Largest UMNs in M1
Layer 5
How many layers does the primary motor cortex have?
6
What is the association motor cortex?
Cerebral cortex outside the primary areas
What is the function of M1?
Execute movement
What is the function of the secondary motor cortex?
To plan movements and the organization of complex multi-joint movements
by priming LMNs
Role of corticobulbar tract?
Connects UMNs to LMNs in the brainstem and controls motor output of non-ocular motor cranial nerves (aka not CN III)
Role of corticospinal tract?
Conducts impulses from the brain to the spinal cord LMNs to control lateral pathways
What determines which areas of the cerebral cortex take up more space on the spatial map relating the brain to the body’s musculature?
Muscles necessary for fine motor control take up more space
What are the 3 main cranial nerve nuclei targets of the corticobulbar tract? Ipsilateral, contralateral, or bilateral?
5, 7, and 12:
- Trigeminal nucleus
- Facial nucleus
- Hypoglossal nucleus
ALL BILATERAL
What is pyramidal decussation? What does this mean?
Crossing over of the corticospinal tracts that occurs where the medulla meats the spinal cord
Superior to decussation: contralateral control
Inferior to decussation: ipsilateral control
From where does the premotor area receive input? Main function?
From visual cortex and posterior parietal cortex
Coordinates movements to respond to external cues
Main function of supplementary motor area?
Coordinates movements (especially sequenced ones) to respond to internal cues
Does corticospinal activity correlate with muscle force?
YUP
Which activity happens first: M1 or secondary motor cortex?
Secondary motor cortex
What is apraxia?
Inability to execute skilled movement on cue (without paralysis)
Due to SMA or PMA damage
When are AP firing and where when you observe an activity and try to reproduce it?
In the PMA: both during observance and execution
What are extrapyramidal tracts?
UMN descending axons from the midbrain to the spinal cord that represent an indirect pathway to communicate with LMNs
What is the Babinski sign?
This test is run on infants to test for normal development. If you run a probe from bottom to top on plant of foot, you should witness toe flexion.
Toe extension (fanning up) is a positive result and indicates UMN damage or poor development.
What are the 4 extrapyramidal tracts? Does each connect to lateral pathways or ventromedial pathways?
- Colliculospinal tract: ventromedial pathways
- Rubrospinal tract: lateral pathways
- Reticulospinal tract: ventromedial pathways
- Vestibulospinal tract: ventromedial pathways
What is spastic paralysis?
Increase in muscle tone due to UMN damage
Role of colliculospinal tract? Location?
Connect superior colliculus (in tectum) to LMNs in cervical cord to control the head movement in response to visual stimuli
Right next to anterior corticospinal tract
Role of rubrospinal tract? Location?
Connect red nucleus in pons to LMNs in cervical cord to control upper limb movement (arms)
Right next to lateral corticospinal tract
Role of reticulospinal tract? Location?
Connect reticular formation to LMNs at all levels of the spinal cord for control of posture and locomotion
Right next to anterior corticospinal tract
Role of vestibulospinal tract? Location?
Connect vestibular nuclei to LMNs at all levels of the spinal cord for control of posture and locomotion
Right next to anterior corticospinal tract
Are large or small lesions of M1 more common?
Large lesions
What part of the body will lesions to M1 affect?
Contralateral portions
Primary Lateral Sclerosis (PLS): UMN or LMN damage?
UMN
Amyotrophic Lateral Sclerosis (ALS): UMN or LMN damage?
BOTH!
What is clonus?
Spasticity in feet of patients with UMN damage where the feet will uncontrollably flex the foot after the doctor dorsoflexes it
What are primary afferent sensory nerves?
Sensory nerves from the intrafusal fibers to the spinal cord
Why do alpha neurons of larger motor units have a decreased PSP decay constant?
Because they last longer
Does the Ia afferent neuron fire signals when the muscle is contracted?
NOPE
Which will fatigue faster: slow motor units or fast fatigue-resistant motor units?
Fast fatigue-resistant motor units
Where is the medial white matter of the spinal cord?
In between the ventral horns
Are cranial nerves LMNs or UMNs?
LMNs
What are the 2 types of corticospinal tracts? What does their names indicate?
- Lateral
- Anterior
Indicate where they are located in spinal cord
Where are UMNs located?
- Motor cortex
2. Brainstem
What are the 3 parts of the motor cortex?
- Primary Motor Cortex
- Premotor Cortex or Area
- Supplementary Motor Area
Where do the UMNs that innervate the cranial nerves come from?
Motor cortex