Lecture Slides Flashcards
Concerning asthma chronic disease results in what two manifestations?
- air way hyper responsiveness
- air inflammation induced remodeling
Extrinsic asthma is dependent upon what?
IgE
TH2 cells secrete what cytokines in a hypersensitivity type I RXN?
IL-4, IL-5, IL-13
IL-4 induces B cells to produce what antibody?
IgE
Mast cells that have bound IgE in their Fc receptors are said to be what?
Sensitized
In chronic/severe asthma airway remodeling is mediated via what cytokine?
TGF-beta
Autoimmune bullous skin diseases result from antibodies binding what?
Desmoglein and bullous pemphigoid proteins
Where is desmoglein 1 located?
Superficial layer of epidermis
Where is desmoglein 3 located?
Basal layer of epidermis and throughout mucous membrane epithelium
Where is BP 230/180 located?
Hemidesmosome
What is it called when patient epithelium is incubated w/ a fluoroprobe labeled antibody?
DIF- direct immunofluoresence
What is it called when patient serum is incubated w/ a primary antibody and a secondary fluoroprobe labeled antibody binds to the target bound primary antibody?
IDIF- Indirect immunoflourescence
What solid organ rejection occurs in minutes to hours, has preformed anti-donor antibodies and compliment activation, ex: ABO incompatibility?
Hyper acute
What type of solid organ transplant rejection can occur w/ pregnancy, blood transfusion, previous organ transplant, infection by cross reactivity?
Hyper acute
Abs binding graft, complement products attract neutrophils which release lyric enzymes, lytic enzymes destroy endothelium, MAC formed, platelets adhere to injured tissue causing vasculature damage describes what?
Hyper acute rejection
Re activation of sensitized T cells refers to what kind if solid organ transplant rejection?
Accelerated
What type of solid organ transplant rejection occurs from days to weeks, has primary activation of T cells by donor APC’s, direct allo recognition, CD8+ T cells?
Acute
Donor DC’s migrate to spleen where they activate effector T cells, effector T cells migrate to graft via blood, graft destroyed by effector T cells via direct allo recognition, inflamed state of organ activates organs DC’s describes what?
Acute rejection
What type of solid organ transplant rejection occurs from months to years, causes are unclear, presence of antibody immune complexes, slow cellular reaction, via indirect allo recognition, CD4+ T cell mediated?
Chronic
Vasculature changes in graft lead go loss of function, vasculature changes often due to T cells and B cells (antibody) against HLA molecules expressed on the donor kidney describes what?
Chronic Rejection
In a HSC transplantation what type of matching is important for the reconstitution of the recipients immune response?
HLA
What type of transplantation is most sensitive to HLA mismatching?
Bone marrow transplantation
Transplantation of cells, tissues, organs from one part of the body to another part of the body describes what?
Autograft
Transplantation of cells, tissues, or organs between genetically identical individuals describes what?
Isograft
