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Immunology > Lecture Slides > Flashcards

Lecture Slides Flashcards

0
Q

Concerning asthma chronic disease results in what two manifestations?

A
  • air way hyper responsiveness

- air inflammation induced remodeling

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1
Q

Extrinsic asthma is dependent upon what?

A

IgE

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2
Q

TH2 cells secrete what cytokines in a hypersensitivity type I RXN?

A

IL-4, IL-5, IL-13

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3
Q

IL-4 induces B cells to produce what antibody?

A

IgE

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4
Q

Mast cells that have bound IgE in their Fc receptors are said to be what?

A

Sensitized

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5
Q

In chronic/severe asthma airway remodeling is mediated via what cytokine?

A

TGF-beta

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6
Q

Autoimmune bullous skin diseases result from antibodies binding what?

A

Desmoglein and bullous pemphigoid proteins

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7
Q

Where is desmoglein 1 located?

A

Superficial layer of epidermis

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8
Q

Where is desmoglein 3 located?

A

Basal layer of epidermis and throughout mucous membrane epithelium

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9
Q

Where is BP 230/180 located?

A

Hemidesmosome

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10
Q

What is it called when patient epithelium is incubated w/ a fluoroprobe labeled antibody?

A

DIF- direct immunofluoresence

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11
Q

What is it called when patient serum is incubated w/ a primary antibody and a secondary fluoroprobe labeled antibody binds to the target bound primary antibody?

A

IDIF- Indirect immunoflourescence

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12
Q

What solid organ rejection occurs in minutes to hours, has preformed anti-donor antibodies and compliment activation, ex: ABO incompatibility?

A

Hyper acute

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13
Q

What type of solid organ transplant rejection can occur w/ pregnancy, blood transfusion, previous organ transplant, infection by cross reactivity?

A

Hyper acute

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14
Q

Abs binding graft, complement products attract neutrophils which release lyric enzymes, lytic enzymes destroy endothelium, MAC formed, platelets adhere to injured tissue causing vasculature damage describes what?

A

Hyper acute rejection

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15
Q

Re activation of sensitized T cells refers to what kind if solid organ transplant rejection?

A

Accelerated

16
Q

What type of solid organ transplant rejection occurs from days to weeks, has primary activation of T cells by donor APC’s, direct allo recognition, CD8+ T cells?

A

Acute

17
Q

Donor DC’s migrate to spleen where they activate effector T cells, effector T cells migrate to graft via blood, graft destroyed by effector T cells via direct allo recognition, inflamed state of organ activates organs DC’s describes what?

A

Acute rejection

18
Q

What type of solid organ transplant rejection occurs from months to years, causes are unclear, presence of antibody immune complexes, slow cellular reaction, via indirect allo recognition, CD4+ T cell mediated?

A

Chronic

19
Q

Vasculature changes in graft lead go loss of function, vasculature changes often due to T cells and B cells (antibody) against HLA molecules expressed on the donor kidney describes what?

A

Chronic Rejection

20
Q

In a HSC transplantation what type of matching is important for the reconstitution of the recipients immune response?

A

HLA

21
Q

What type of transplantation is most sensitive to HLA mismatching?

A

Bone marrow transplantation

22
Q

Transplantation of cells, tissues, organs from one part of the body to another part of the body describes what?

A

Autograft

23
Q

Transplantation of cells, tissues, or organs between genetically identical individuals describes what?

A

Isograft

24
Q

Transplantation of cells, tissues, or organs between members of the same species describes what?

A

Isograft

25
Q

Transplantation of cells, tissues or organs between members of different species describes what?

A

Xenograft

26
Q

What are the two main barriers to transplantation?

A

Blood group antigens

Tissue antigen compatibility

27
Q

What type of antigens induce the strongest immune response in transplantation?

A

MHC antigen

28
Q

T cells recognize unprocessed allogenic MHC molecule on graft APC (can activate many T cell clones), CD8+ T cells describes what?

A

Direct allogenic recognition

29
Q

Presentation of processed peptide of allogenic MHC molecule bound to self MHC molecule (just a few CD4+ T cells specific for the processed allogenic peptide can be activated this way) describes what?

A

Indirect alloantigen recognition

30
Q

A model of direct T cell recognition of allogenic MHC molecules, differences in MHC will lead to proliferation of allo reactive T cells describes what?

A

Mixed Lymphocyte Reaction

Immunology (5 decks)

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