lecture exam 1 Flashcards
three chemcical bonds
hydrogen, covalent, and ionic bonds
order of the least strongest to strongest bond
hydrogen, ionic, polar covalent, non-polar covalent
polar cavelnt molecule
water
four types of inorganic compounds
water, acids, bases, salts (ionic-anions and cations in water), do not contain carbon atoms in chain
universal solvent
water because it is abundant, high heat capacity, and a thermoregulator
buffers
acid-balance regulators, able to resis abrupt changes to the pH by binding to H+ when pH drops
organic compounds
carbs (-saccharides), lipids (fats), nucleic acids (DNA and RNA), proteins
disaccharides
sucrose, lacose, maltose (linked by glycosidic bonds)
primary protien structure
linear chain
secondary protein structure
alphs helox or beta pleated sheet
tertiary protein structure
proteins coil to make 3D shape
quaternary protein structure
two or more polypeptide chains held by disulfide bonds
structural proteins
secondary structure, insoluble, mechanical support and are in an strand-like shape
fucntional proteins
soluble, (3/4 structure), ball-like, sensitive to low pH and high temp
fibrous proteins
structural proteins
denaturation
high temp and low pH levels
lipids
neutral fats, phospholpids, steriods, eicosanoids
unsaturated fats
double covalent bonds, liquid and plant based
saturated fats
single covalent bond, solid and animal based
what causes LDL proteins
the excess consumption of saturated fats
good cholesterol
HDLs
bad cholesterol
LDLs, the excess cholesterol increases and the amount of plaque increases causing it to clog the arteries and prevent blood flow
phospholipids
glycerol bakcbone,2 fatty acid chain, and a phosphorous containing group
what receptors fo steriodogenic cells express?
LDL receptors because LDL binds to LDL receptors o the surface of steriodogenic cells and are taken in via receptor-mediated endocytosis
eicosanoids
cyclooxygenase produces prostaglandin
use of aspirin
asprin manages thromboembolic disorders because it inhibits cyclooxygenase. thromboxane mediated blood clot formation and aspirin combats these disorders which is why it’s used to prevent thrombi and emboli from forming
three major parts of a cell
plasma membrane, cytoplasm, and nucleus
plasma membrane
boundary of cell
cytoplasm
interior of cell b/w membrane and nucleus
nucleus
contains genes which control activities in the cell
function of cholesterol in membrane
embedded in the tails of phospholipids (fatty acid tails), this stabilizes the unsaturated fats which stabilizes the membrane
integral proteins
important for movement of cells across the membrane
peripheral proteins
attached to the surface of integral proteins
transmembrane proteins
allows the transportation of specific substances along the membrane
membrane junctions
tight jucntions, desmosomes, gap junctions
tight junctions
impermeable junctions
desmosomes
anchoring junctions
gap junctions
communicating junctions
connexons
allow transfer of ions and small signaling molecules
linker proteins
are short amino acid sequences that separate mulitple domain in a single protein
membrane transport
active and passive processes
passive processes
simple diffusion, facilitated diffusion, osmosis, and filtration
simple diffusion
small, nonpolar molecules pass through lipid bilayer of the membrane (hydrophobic)
facilitated diffusion
facilitated polar, hydrophobic substances that cannot cross the bilayer without carrier proteins (transports integral proteins)
osmosis
movement of water from low to high concentrations through a semipermeable membrane (aquaporins)
filtration
down pressure gradient (no ATP) (urine formation through kidneys)
tonicity
0.5 and 9 NaCl = isotonic
less than that = hypotonic (bursts)
more tha that = hypertonic (shrink)
active processes
active transport and vesicular transport (bulk transport)
active transport
movement from low to high concentration gradients (solute pumping) (Na/K pump) against gradient
vesicular transport
endocytosis and exocytosis
endocytosis
movement into cells (nutrients etc)
exocytosis
movement out of cells (protein secretion)
three types of endocytosis
phagocytosis, pinocytosis, receptor-mediated endocytosis
phagocytosis
moves solid particles from exterior into the cells
pinocytosis
movement of solutio into cels by enclosing the soution into escile (pinocytic vesicles)
receptor-mediated endocytosis
substance binds to specific receptors on the surface of the cell and are taken into the cell
mitochondria
powers plants
ribosomes
site of protein synthesis
rough er
membrane factories
smooth er
lipid and drug detoxification
lysosomes
demolition crew
peroxisomes
neutralize harmful free radicals
golgi apparatus
traffic director
protein secreting cells
rought er, golgi apparatus (strong presence of ribosomes)
drug detox and steriod hormones
smooth er
cytoskeleton
microtubules: 25 nm
intermediate filaments: 10 nm
micofilaments: 7 nm
structural different between cilia and flagella
cilia: slender, microscopic structure (short hair)
flagella: long hair-like structure that is complex
functional differences between cilia and flagella
cilia are faster and more efficient and are more abundant
flagella have one strand and not as efficient (sperm)
nucleus
nuclear membrane, nucleolus, nucleoli
nucleosomes
make up chromatin
fucntions of histone proteins
strcutural framework to support the delicate thread-like DNA to prevent twisting
regulate DNA
euchromatin
DNA extended and comes off histone proteins, active for transcrition and DNA replication
heterochromatin
DNA wrapped around histone proteins (inactive)
cell cycle
G1: cell growth by hypertrophy
S: DNA replication in addition to cell growth (results in two DNA molecules)
G2: protein synthesis espeically of proteins required for all cell divison
cell divison: nuclear division (PMAT:prophase, metaphase, anaphase, telophase) finished with cytokinesis to split into 2 cells
hypertrophy
growth by increase of cell size
hyperplasia
growth by increase of cell # via mitosis
neoplasia
excessive rapid increase of abnormal cells
transcription v replication
transcription: copy of DNA to to make an RNA molecule
replication: copy of DNA befoer cell divison
coding strand
not used in transcription process
DNA v RNA
DNA: double stranded molecule that is a long chain of nucleotides
RNA: single stranded molcule that is a short chain of nucleotides (cannot replicate itself)
pre-mRNA v mRNA
pre: first product of the gene and contains both non-coding and coding sequences
mRNA: second product, only containing coding sequences
triplet
3 base sequences in DNA
codon
3 base sequences in mRNA
anticodon
3 base sequences in RNA
genetic code
mRNA is transcribed from a gene and is transcribed
redundancy of genetic code
most amino acids are specified from one or more mRNA codon
protein synthesis
translation and transcription
RNA editing and splicing
the process of modifying RNA nucleotides to change the amino acids sequences. this involves editing specific nucleotides
coding strand for DNA
non-template strand becase this sequence will remain the same as the new RNA mlcl
four primary types of tissues
epithelial tissues: cover
CT: support
Muscle: movement
nervous; control
two types of ET
simple and stratified
mesothelium
double layered, lines the vertebral cavity (inside seroud membrane), simple squamos ET
endothelium
lines the cardiovascular system, simples squamos ET
respiratory ET
pseudostratified columnar ET, lines the structures in the respiratory system (ciliated)
transitional ET
lining urinary system (allows urine to go through body’s surface)
2 types of glandular ET
endocrine and exocrine glands
endocrine glands
secreted hormones in extracellular fluid
exocrine glands
secretes product into body’s surface
subtypes of exocrine
structural and functional glands
globet cells
secretes mucin that uses cilia to move the cell debris away and has a duct system
simples multicellular exocrine glands
unbranched
compound multicellular exocrine glands
branched
tubular multicellular excorine glands
secretory proteins, tube like
alveolar multicellular exocrine glands
secretory proteins, flask like sacs
tubuloalveolar multicellular exocrine glands
secretory proteins, tubes and flask like sacs
fucntionsl classes of multicellular exocrine glands (secretion)
apocrine, merocrine, holocrine
apocrine
the apex is pinched off and the product oozed into ducts
merocrine
mae inside cells and enclosed inside vesicles, the. moved to plasma membrane and fused to it and products are released
holocrine
the cells is not enclosed to the duct because they are too heacy to they rupture and are released into the cells
secretion mode not used by glands in human body
apocrine?
nonliving CT
extracellular matrix, has al three fibers
living CT
cells that are derived from mesenchyme and prpduce tissue
mesenchyme
where all living cells come from
2 types of connective proper
loose and dense tissue
dense tissue
also known as fibrous tissue because they are densely packed
“packing material” of the body
areolar CT
dense regular connective tissue
runs in one direction and it’s found in tendons and ligaments
dense irregular tissue
runs in different directions and resisits tension, highly vasuclarized and found under poorly vascularized tissue (dense regular CT)
found in ther dermis of skin and fibrous capsules in synovial membrane
cell that secretes cartilage
chondroblasts
pericondrium
dense irregular CT
consistency of the matrix of cartilage
semi-solid matrix
three types of cartilage
hyaline, elastic, fibrocartilage
hyaline cartilage
part of the embryonic skeleton, is articular cartilage, epiphyseal plate
elastic cartilage
found in the pinna:ear) and epiglottis
fibrocartilage
connected by intervertebral discs, found in joints
what cell secretes bone tissue
osteoblasts
4 classes of CT
fibroblasts, osteoblasts, chondroblasts, hematopoietic
bone tissue
solid matrix, osteiod is the organic matrix, hydrooxypatites are the inorganic matrix, once the organic matrix begins to grow, it’s invaded by the inorganic matrix and this is what causes the matrix to soldify)
hematopoietic stem cells
secretes blood, fluid matrix is blood plasma
blood and bone tissue relation
both made up of CT and this connects and supports other body parts, so they similar functions
3 muscle tissues
smooth, cardiac, skeletal
cardiac
has striations, uninucleate, undergoes involuntary control and found in walls of heart
skeletal
multinucleated, voluntary control, striations, found in skeletal muscle attached to bones and skin
smooth
involuntary control, no observable striations, walls of hollow organs
involuntary control
cardiac and smooth
striations
cardiac and skeletal
glial cells
found in nervous tissue, provides with protection and insulaton
neurons
in nervous tissue, waves of excitement
mucous membranes
overlying: nonkeratinized stratified squamous ET
underlying tissue areolar tissuse
serous membrane
overlying: simple squamous ET
underlying: areolar tissue
synovial membrane
overlying: dense irregular CT
underlying: areolar CT
mesothelium
simple squamous ET only in serous membrane
lamina propia
areolar CT only in mucous membrane
membrane regarding skin
cutaneous membrane
membrane composed of 2 types of CT
cutaneous, muscous, serous