Lecture 9.B. - Intro to Gut Microbiota Flashcards
Moving from the proximal GI tube to the distal, the microbiota progress from _____ (aerobes or anaerobes?) to _____ (aerobes or anaerobes?).
Aerobes
Anaerobes
F. A. B. P. is the acronym for the most common GI bacterial phyla. What do the letters stand for?
Firmicutes
Actinobacteria
Bacteroidetes
Proteobacteria
When children begin eating solid food, there is a transition in microbiota composition from ______ dominance to ______ dominance. When children first receive antibiotic treatments, _______ become more dominant. In malnutrition, ________ becomes dominant.
In healthy adults, _______ become dominant, but in the obese and elderly, Proteobacteria expand a bit.
Actinobacteria to Bacteroides
Bacteroides
Proteobacteria
Firmicutes
In general, low fat plant-based polysacharride-rich diets with probiotics and no antibiotics will favor _______ over ______. The opposite is true for a western diet and antibiotic treatment.
Bacteroidetes
Firmicutes
Plant-based diets result in the production of bacterial _____, TGF-____, and SCFAs –> these act as inducers of _____ immune cells and appropriate immune homeostasis.
Western diets high in animal proteins and fat result in the dominance of SFB (Segemented Filamentous Bacteria) and cause the secretion of _____ by the lamina propria –> this is a potent inducer of proinflammatory _____ cells.
Bacterial Polysaccharide A (PSA)
TGF-Beta
Tregs
Serum Amyloid A (SAA)
Th17
Patients with Crohns Disease show a collapse of Bacteroidetes and an expansion of _________.
Patients with Ulcerative Colitis show an expansion of _______.
Actinobacteria
Proteobacteria
Intracellular TLR-___ recognizes ___RNA and intracellular TLR-___ recognizes __RNA –> both provide defense against viruses.
TLR-3 –> dsRNA
TLR-8 –> ssRNA
C. diff infection can recur bc even when the bacteria are killed, their _____ can remain and grow.
Spores
