Lecture 9 Protein Folding III Flashcards
1
Q
Protein Misfolding
A
Incorrectly folded proteins are detected by quality-control mechanism
Overwhelming working proteasome system or malfunctioning check-system casue the accumulation of misfolded protein in the cell
They are prone to inappropriate interaction with other molecules within the crowded environment of a cell (Protein-Protein interactions)
2
Q
Normal proteins contain
A
More alpha helix and little Beta strand
3
Q
Beta strands in aggregated protein
A
Link together and lead to formation of aggregates
4
Q
Amyloid fibrils
A
Fibrous protein aggregates
5
Q
How does amyloid progress to amyloid plaques
A
Seeding -
6
Q
Ubiquitin
A
Detect proteins, grind down to degraded protein that get re-used in protein synthesis
7
Q
Lowest E state is
A
Native state, proteins prefer this
