Lecture 9 Novel Dosage Forms

Question 1

What are novel dosage forms?

Answer 1

Dosage forms that are relatively new on the market or use new and/or unique delivery systems.

Question 2

What are the benefits of novel dosage forms?

Answer 2

Improved patient compliance and acceptance
Improved outcomes
Reduction of side effects
Avoidance of patient interventions
Allows patients to receive medicines as outpatients
Reduction in the overall use of medicinal resources

Question 3

What are examples of topical delivery novel dosage forms?

Answer 3

Iontophoresis and phonophoresis(sonophoresis)

Question 4

What is Iontophoresis?

Answer 4

Electrochemical method to enhance transport of drug through the skin with an applied electrical current.

Question 5

What is Phonophoresis(Sonophoresis)?

Answer 5

combination of ultrasound therapy with topical therapy to achieve therapeutic concentrations of drug.

Question 6

What are examples of oral drugs that are novel dosage forms?

Answer 6

Instantly Disintegrating Tablets/Films
Chewable Dispersible Tablets
Mucoadhesive Systems
Osmotic Pumps
Oral Inhalation

Question 7

What are instantly disintegrating tablets/films?

Answer 7

Solid dosage forms that dissolve or disintegrate rapidly in the oral cavity, resulting in a solution or suspension without the addition of water.

Question 8

What are the advantages of instantly disintegrating tablets/films?

Answer 8

Enhanced oral bioavailability

Improved patient compliance

Question 9

What are chewable dispersible tablets?

Answer 9

Formulated to be chewed or swallowed whole, eliminates disintegration step.

Question 10

What are mucoadhesive systems?

Answer 10

Mucoadhesion is commonly used to describe an interaction between the mucin layer lining the entire GI tract and a bioadhesive polymer, which could be of natural or synthetic origin.

Question 11

What are the advantages of a mucoadhesive system?

Answer 11

• Immediate and prolonged contact w/ absorbing membrane
• Prolonged and controlled GI transit
• Site-specific drug delivery
• Potential for delivering drugs that undergo considerable first-pass metabolism.

Question 12

What are osmotic pumps?

Answer 12

• Core tablet surrounded by a semipermeable membrane with a laser-produced hole. The release of drug is based on the osmotic pressure of the system.
• Provides predictable rates of drug delivery independent of GI mobility and pH of luminal fluids

Question 13

What do oral inhalations do?

Answer 13

• Provide drug directly to target organs

- Bypasses deleterious first-pass, GI effects

Question 14

What are delivery systems for intravaginal/intrauterine drugs?

Answer 14

• Progesterone Intrauterine
• Drug Delivery Systems
• Dinoprostone Vaginal Inserts
• Estring
• Crinone Gel

Question 15

What are the advantages of vaginal/uterine administration?

Answer 15

• Self-insertion and removal
• Continuous administration of drug at effective dose level
• Improved patient compliance

Question 16

What are delivery systems for ophthalmic administration?

Answer 16

• Gels

- Inserts

Question 17

What are the advantages of ophthalmic administration?

Answer 17

• Prolonged controlled delivery of drug

- Provide prolonged contact with the eye