Lecture 9 - Gene Mapping In Complex Diseases Flashcards
1
Q
Gene Mapping Methods
A
Linkage Analysis
Association Analysis
2
Q
Linkage Disequilibrium Definition
A
Non Random association of alleles at different loci
Allelic association shown if allelic frequency of alleles are significantly different to individual allele frequency
3
Q
Case/Control Definition
A
Most common association study method
Uses Odds Ratio
4
Q
Odds Ratio Definition
A
Ratio of number of ways an event can occur relative to number of ways an event can’t occur
5
Q
Confidence Interval Definition
A
A range expected to contain the true value of a population parameter
6
Q
Diabetes Definition
A
Abnormal High Blood Sugar Levels
7
Q
Number of DSL’s of Type 1 Diabetes
A
18
8
Q
Challenges in Finding Genes
A
Inadequate Sample Size
Difficult to define phenotype
Reduced Penetrance
