Lecture 9 - Drugs & Allergy Flashcards
List some Allergic Disorders that we discussed
- Allergic Rhinitis (hay fever)
- Allergic Conjunctivitis (pink eye)
- Atopic Dermatitis (eczema)
- Urticaria (hives)
- Asthma (inflammation of airways)
- Anaphylaxis (multi-organ allergic reaction)
Define what an allergy is
- Inflammatory disorder (hyper immune response to allergens)
- Maladaptive immune system response creating memory to antigens
Maladaptive
not providing adequate or appropriate adjustment to the environment or situation
What are the key players/immune cells involved in allergic reactions?
- IgE
- mast cells
- basophils
- eosinophils
- dendritic cells
- T-cells (Th1&2)
- B-cells
- plasma cells
What are mast cells?
Tissue cells of the immune system found in loose connective tissue, organs, vasculature, nerves, skin, respiratory tract, etc.
Where are mast cells not present?
in epidermal cells, CNS, gastric mucosa
What do mast cells store?
Store histamine, interleukins, proteoglycans (ex. heparin) and various enzymes in their granules at cytoplasm
When are mast cell granules released?
they are released upon stimulation an allergen; degranulation
What does mast cell degranulation cause?
- increased blood flow and permeability of blood vessels (i.e. inflammation and swelling)
- contraction of smooth muscles (ex. bronchial muscles)
- increased mucous production & fluid secretion
What allergy symptoms do histamine and prostaglandin cause?
- tickling
- itchiness
- nose rubbing
- allergic salute
What allergy symptoms do histamine and leukotrienes cause?
- sneezing
- runny nose (mucosal secretion)
- post nasal drip
- throat clearing
What allergy symptoms do histamine, leukotrienes, bradykinin, platelet activating factor (PAF) cause?
- nasal congestion
- mouth breeding
- stuffy nose (mucosal edema)
- snoring
Histamine is an autacoid. What does autacoid mean?
self relief
Where is histamine stored?
-stored in tissue mast cells and blood basophils
What is histamine released by?
- antigens; allergic responses (immediate hypersensitivity)
- drugs; morphine, succinylcholine, radio contrast media
- insect venoms
- physical factors; scratching, cold
How many H (histamine) receptors are there?
4
Which H receptor is the most important for allergic disorder and is the classic target for “antihistamines”?
H1
What does binding to the H1 receptor cause?
- contraction; gastric and respiratory smooth muscle (H1)
- vasodilation (H1 and H2)
- increased vascular permeability (H1)
- pruritis “itching” (H1)
- increased bronchial secretions and viscosity (H1)
- bronchoconstriction
What does binding to the H2 receptor cause?
- receptor stimulation mediates gastric acid secretion (H2)
- receptor blockage decreases gut acidity (ranitidine)
What does binding to the H3 receptor cause?
- cholinergic neurotransmission (airway)
- negative feedback mechanism; inhibit histamine, NE and acetylcholine release
What does binding to the H4 receptor cause?
chemotaxis of mast cells, eosinophils, neutrophils. Cytokine release from T and dendritic cells
What happens when histamine is pricked onto skin?
It produces a triple response:
1 - RED area at site of injection (vasodilation)
2 - WHEAL replaces red area - edema
3 - bright red FLARE - indirect vasodilation (axonal reflex)
Allergic rhinitis is known as ?
hay fever bitches
List some symptoms of allergic rhinitis
-rhinorrhea (runny nose), plugged nasal passages, itching (eyes, nose and throat) tearing, fatigue, headache
List 2 branches of allergic rhinitis
1: Seasonal (airborne pollen)
2: Perennial (animal dander, mold, dust, etc.)
___% of patients with rhinitis present with asthma
40
__% of asthmatics experience rhinitis
70
Allergic Rhinitis prevalence in North America = ___%
20
3 treatment options for AR are?
- Avoidance
- Pharmacotherapy
- Immunotherapy
What pharmacological options are available for the treatment of AR?
- antihistamines
- intranasal glucocorticoids
- leukotriene modifiers
- decongestants
- mast cell stabilizers
- anticholinergic
- anti-IgE therapy
- systemic steroids (not preferred)
List some antihistamines
- chlorpheniramine
- diphenhydramine
- cetirizine
- loratidine
- fexofenadine
List an intranasal glucocorticoid
-fluticasone
List a leukotriene modifier
-montelukast
List some decongestants
- phenylephrine
- pseudoephedrine
List a mast cell stabilizer
-cromolyn sodium
List an anticholinergic
-ipratropium
List an anti-IgE therapy
-omalizumab