Lecture 10 - Drugs & Asthma/COPD Flashcards
What is COPD?
slow progressive airway obstruction due to chronic inflammation
COPD is common in _____.
smokers
Other causes of COPD?
air pollution and occupational exposures
Symptoms of COPD?
- cough
- mucus hypersecretion
- dyspnea (shortness of breath)
What does COPD include?
- chronic bronchitis (inflammation of bronchi)
- emphysema (destruction of alveolar structure - airways collapse during expiration)
What is asthma?
chronic inflammatory disorder of the airways
What is asthma characterized by?
recurring episodes of hyper responsiveness to stimuli that causes bronchoconstriction
Symptoms of asthma?
recurring episodes of cough, wheezing, tight chest, dyspnea (shortness of breath)
What is asthma based on?
triggering stimuli characterized as extrinsic (allergenic) or intrinsic (non-allergenic)
extrinsic asthma = ?
allergenic
intrinsic asthma = ?
non-allergenic
Describe extrinsic asthma (allergenic)
- External stimuli such as environmental allergens (dust, mold, pollen, dander, foods) trigger plasma cells to produce antigen specific IgE antibodies
- Allergen & IgE binding to mast cells result in degranulation and release of inflammatory mediators
- Allergens typically have some glycoproteins that immune cells recognize as an antigen, a harmful substance that induced immune cells to produce antibody (IgE) that specially recognize the antigen
Describe Intrinsic Asthma
- Non-allergenic asthma
- Symptoms triggered by non-allergenic factors (anxiety, stress, cold air, dry air, smoke, exercise, viruses)
- The mechanisms initiating the asthma attack are not completely understood:
- Abnormalities in the autonomic regulation of airway functions suggested to increase responsiveness.
- The innate immune system involved, the role of adaptive immune system remains elusive.
What are the asthma symptoms amenable to drug therapy?
- Excessive airway smooth muscle tone
- Inflammation
- Mucus plugging
- Pulmonary edema
Asthma & COPD Drugs:
Drugs divided based on treatment strategies?
1) controllers
2) relievers
Asthma & COPD Drugs:
Drugs divided based on targets?
1) Airway muscle tone:
- Bronchodilators (Beta-adrenergic, methylxanthines, anticholinergics, leukotriene modifiers)
2) Inflammation:
- Anti-inflammatory agents (Corticosteroids, mast cell stabilizers, anti-IgE monoclonal-antibody, leukotriene modifiers)
What are bronchodilators?
Agents that interact with smooth muscle cells lining the airways (bronchiole) and relax smooth muscles
List some Beta-adrenergic bronchodilators
- Albuterol/Salbutamol
- Terbutaline
- Salmeterol
List a Methylxanthine bronchodilator
-Theophylline
List some anticholinergic bronchodilators
- Tiotropium
- Ipratropium
List some leukotriene modifier bronchodilators
- Zileuton
- Zafirlukast
- Montelukast
Sympathetic nervous system causes ________
bronchodilation
running from tiger, need air to breath
Parasympathetic nervous system causes _______
bronchoconstriction
just relaxing to the max so you don’t need to breath too hard
What receptor causes bronchodilation?
B2 (sympathetic)
What receptor causes bronchoconstriction?
M3 (parasympathetic)
Ca2+ increase causes _______
bronchoconstriction
Ca2+ decrease causes _______
bronchodilation
Describe how bronchoconstriction happens
Activation of parasympathetic nervous system:
- ACh binds to M3 receptors
- Activation of Gq
- PLC activation
- Increased DAG and IP3 hydrolysis
- increase of cytoplasmic Ca2+
- Ca2+ calmodulin activates myosin via MLCK
- myosin binds to actin –> actin slide past myosin
- contraction (that occurs as long as Ca2+ is present)
*Adenosine also increases Ca2+ levels (PLC activation via A1 receptor)
Describe how bronchodilation happens
- Activation of beta2 receptor, GPCR (NE, E)
- Activation of Gs
- AC activation
- ATP converted into cAMP - PKA activation:
1) promotion of SR Ca2+ pumps causes a decrease in cytoplasmic Ca2+
2) inhibition of MLCK, enzyme activation myosin, prevents myosin binding to actin - dilation/relaxation
Albuterol/Salbutamol and Terbutaline are ____-acting
short
Salmeterol are ____-acting
long (12 hours)
MOA of B2 agonists
Stimulate AC thereby increasing the formation of cAMP which acts to relax the airway smooth muscle leading to bronchodilation
Route of admin of B2 agonists
Typically administered via inhalation:
- Albuterol and Terbutaline available in tablet form
- Terbutaline can also be administered SC
Indication of B2 agonists
- Extensively used in the treatment of asthma
- In inhaled form, Albuterol is the DOC for the treatment of acute attacks. For severe attacks, SC injection of Terbutaline or epinephrine may be required along with corticosteroids
What is the DOC for the treatment of acute asthma attacks?
Albuterol (inhaled form)
What is the DOC for the treatment of severe asthma attacks?
SC injection of Terbutaline or epinephrine may be required along with corticosteroids
We do we co-administer corticosteroids with anti-inflammatory drugs?
to prevent the development of desensitization and promote efficacy of B2 agonists
Adverse effects of B2 agonists?
- B1 receptors on the heart may get stimulated causing tachycardia
- skeletal muscle tremor
- tolerance may develop with very frequent use
Drug interactions with B2 agonists?
- Not effective on patient taking propranolol for HTN or other heart/circulatory conditions
- Co-administration of long term B2 receptor agonists with corticosteroids prevents desensitization.
Theophylline is a _____
Methylxanthine