Lecture 8- Retina 4 Amacrine Cells Flashcards

1
Q

What NT do ALL amacrine cells contain? Some also contain?

A

ALL - GABA or glycine Some - Ach, DA, ATP, NP

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2
Q

How many types of Amacrine cells are there?

A

22

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3
Q

Why is it referred to as a BP Dyad synapse?

A

Referred to as a Dyad because there are 2 elements. In the IPL, all BP contact at least 2 elements - either a GC and amacrine cell or 2 amacrine cells (rod pathway)

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4
Q

In an animal that does not have GABA receptor, the BP response fires smaller or bigger AP?

A

Fires bigger AP. This shows that amacrine cells fine tunes the “through” response.

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5
Q

Difference between cone and rod BP in relation to whether they synapses onto amacrine cells/GCs or not?

A

Cone BP synapses with GCs Rod BP only synapses with two amacrine cells (DOES NOT synapses with GCs)

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6
Q

What receptors are on Rod-BP?

A

mGluR6 - same as ON BP

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7
Q

40% of all amacrine cells are? They express ____R which releases ____

A

A2, kainate (iGluR), Glycine as NT - inhibiting the ON and OFF BP it synapses onto

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8
Q

Where is the max vision in rod system? *It is where A2 amacrine cells are at their highest density

A

Around 8 degrees

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9
Q

Do BP create directional selectivity?

A

No - response will be same in either direction light is shone. They only create firing pattern.

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10
Q

What NT do starburst amacrine cells release?

A

GABA and Ach

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11
Q

What cells are responsible for directional selectivity?

A

Starburst amacrine cells

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12
Q

Describe the features of a SBAC

A

1) No axons, only dendrites 2) Only distal part of cell can send outputs out (synapses with directional selective GC) 3) Ca2+ signalling (and hence GABA release) is directional selective - GABA is released when stimulus (light) moves from soma to dendrite but not when the stimulus moves towards the soma 4) Input: Glu, GABA, gly Output: GABA, Ach *Directional selectivity is related to GABA release BUT not with Ach (function unknown currently)

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13
Q

T/F: All amacrine cells are crucial for night vision

A

T

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14
Q

T/F: SBAC are important for motion detection

A

T

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15
Q

What are the main interneuron in the rod pathway?

A

A2 amacrine

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