Lecture 7- Retina 3 Parallel Pathways Flashcards

1
Q

CASE STUDY: Monica -65 year old -Saw water splashing in front of her left eye -Flickering lights -Grade 3 Melanoma excised 4 years ago What’s her problem?

A

Melanoma Associated Retinopathy - antibodies produced targeting against ON BP (mGluR6 or TRPM1 channels) and loses ON BP function -Patient loses B-wave -Patient treated with oral prednisolone

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2
Q

Where does splitting of information occur first?

A

At the first synapse (Ph->BCs)

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3
Q

Two types of GC

A

M-GC (5-10% of all GC): motion, LARGE receptive fields -> low spatial res P-GC: colour, visual acuity, small receptive fields -> high spatial res

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4
Q

iGluR are excit/inhibit? mGluR6 are excit/inhibit?

A

iGluR - excit mGluR6 (only found in retina) - inhibit

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5
Q

OFF cells are de/hyperpol by light? What R?

A

Hyper, AMPA/Kainate

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6
Q

ON cells are de/hyperpol by light? What R?

A

De, mGluR6

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7
Q

What is the difference when comparing the synapses of Ph -> BPs and BP->GCs?

A

BP-> GC ONLY uses iGluRs (NMDA, AMPA, Kainate)

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8
Q

What channel is important in ON BP?

A

TRPM1 (transient receptor potential melanocyte) channel

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9
Q

Receptive field of GC has a centre and an antagonistic surround. What does this mean?

A

Centre of GC does one thing, surround does opposite

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10
Q

What creates the “surround” response?

A

Horizontal cells

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11
Q

Why are edges so important to GC?

A

Red and green GC communicate edges to the brain - they only fire when there are edges present

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12
Q

Melanoma Associated Retinopathy

A

Antibodies produced targeting against ON BP (mGluR6 or TRPM1 channels) and loses ON BP function -Patient loses B-wave -Patient treated with oral prednisolone

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