Lecture 8: Glutamate

Question 1

what forms glutamate

Answer 1

Glutamine

Question 2

enzyme that makes glutamate from glutamine

Answer 2

glumaninase

Question 3

Glu vesicular transporter in hippocampus

Answer 3

VGLUT1

Question 4

Glu vesicular transporter subcortical

Answer 4

VGLUT2

Question 5

Glu vesicular transporter everywhere

Answer 5

VGLUT3

Question 6

Glu transporter on cerebellum and astrocytes

Answer 6

EAAT1

Question 7

Glu transporter on brain and astrocytes

Answer 7

EAAT2

Question 8

Glu transporter most widely distributed

Answer 8

EAAT3

Question 9

Glu transporter on purkinje cells

Answer 9

EAAT4

Question 10

Glu transporter on retina

Answer 10

EAAT5

Question 11

Lou Gherigs disease (ALS)

Answer 11

dysfunctions on EAAT2 (too much flu)

Question 12

3 ionotropic receptors

Answer 12

AMPA, KAINATE, NMDA

Question 13

Kainate and AMPA antagonist

Answer 13

NBQX

Question 14

NMDA antagonist and its isomer friend

Answer 14

DLAP5 (and LPA5) –> reduces memory (increases latency)

Question 15

Binds to NMDA interior receptor site

Answer 15

PCP/Ketamine/MK-801

Question 16

Glu receptor involved in motor control

Answer 16

mGluR1

Question 17

Glu receptors implicated in Scizo (inhibitory effects)

Answer 17

mGluR2/3

agonize these they decrease glu which is good cause schizo has too much glu