Lecture 8 - Fatigue Flashcards
1
Q
Define fatigue and the two main types of fatigue
A
An exercise induced impairment of performance
Central fatigue - CNS
Peripheral - neural mechanical factors and energetica of contraction
2
Q
What is central fatigue, what causes it
A
Reduction in the motor units firing frequency
Peripheral feedback
CNS arousal alters the state of fatigue
3
Q
See notes for hypoglycaemia and serotonin
A
Shag
4
Q
What are the 7 sites of peripheral fatigue
A
Motor neurone Peripheral nerve NMJ E-C coupling Contractile mechanism Metabolic energy supply
5
Q
3 causes of NMJ failure
A
Conduction failure
Altered ACh release
Altered ACh receptor sensitivity
6
Q
What are the products of intense exercise
A
Intense exercise induces high rates of glycolysis and atp hydrolysis increasing Pi H+ and ADP, they interfere with the cross bridge cycle so induce muscle fatigue
7
Q
See the rest of notes for lecture
A
Q
