Lecture 8: Antidepressant Drugs

Question 1

What is depression with mania?

Answer 1

Bipolar disorder.

Question 2

What are the monoamine neurotransmitters involved in depression?

Answer 2

Noradrenaline
Dopamine
Serotonin (5-HT)

Question 3

Out of noradrenaline, dopamine and serotonin, which can have a ligand-gated ion channel receptor type?

Answer 3

Serotonin, all the rest have g-protein coupled receptors.

Question 4

What do monoamine oxidase inhibitors do?

Answer 4

Inhibit the metabolism of monamines (by inhibiting monoamine oxidase).

Question 5

Which are more selective, selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs) or noradrenaline reuptake inhibitors (NRIs)?

Answer 5

SSRIs and NRIs.

Question 6

During the use of antidepressant drugs, do anti-depressive effects or side effects emerge first?

Answer 6

Side effects emerge immediately whereas it can take several weeks to exert an anti-depressive effect.