Lecture 8 - Anatomy of the Autonomic System Flashcards
What would happen to a body if we removed all consciousness?
All physiological processes would continue virtually unchanged because of the ANS (consciousness only represents a tiny fraction of the activities of the NS)
10 functions of ANS?
- Regulates body temp
- Coordinates CV function
- Coordinates respiratory function
- Coordinates digestive function
- Coordinates excretory function
- Coordinates reproductive function
- Adjusts internal water
- Adjusts fluid electrolytes
- Adjusts nutrients in tissue fluids
- Adjusts dissolved gas concentrations in bodily fluids
Other name for ANS?
Visceral motor NS
Which special sense is considered a visceral sensory?
Taste
What 5 general senses are part of the visceral sensory division of the NS?
- Stretch
- Pain
- Temperature
- Chemical changes
- Irritation of viscera
What 3 tissues does the ANS innervate?
- Smooth muscle
- Cardiac muscle
- Glands
What are the 2 main differences between the somatic efferent pathway and the autonomic pathway?
- LMNs of the SNS synapse directly onto skeletal muscle allowing for precise innervation vs autonomic pathways involve 2 neurons (CNS + PNS) and is diffuse with divergent targeting and indirect control
- LMNs are heavily myelinated therefore have faster conduction vs ANS preganglionic neurons are slightly myelinated and postganglionic ones are not at all, therefore have slower conduction
Is ANS conduction faster in the preganglionic or postganglionic nerve?
Preganglionic because slightly myelinated
Where are the autonomic preganglionic neuron bodies found? 2 names
Intermediolateral cell column of spinal cord = lateral horns
Parasympathetic NS: how does the length of the preganglionic neuron compare to the postganglionic neuron? Why?
Longer preganglionic neuron because intramural ganglia are in the walls of the target organs
Sympathetic NS: how does the length of the preganglionic neuron compare to the postganglionic neuron? Why?
Longer postganglionic neuron because paravertebral and prevertebral ganglia are close to spinal cord
What are the 3 autonomic ganglia of the PNS?
- Paravertebral (chain) ganglia
- Prevertebral ganglia
- Intramural ganglia
Describe the organization of the spinal nerves.
Rootlets => dorsal/ventral roots => spinal nerves => dorsal/ventral rami
Describe the 2 sympathetic autonomic motor innervation pathways to viscera. What does each innervate?
- Cardiopulmonary nerves/splanchnics (thoracic cavity): preganglionic neuron in lateral ventral horn of spinal cord => anterior root => spinal nerve => white ramus communicans => synapse in paired paravertebral ganglia (same level/up/down the spinal cord) => postganglionic neuron (cardiopulmonary nerves) => viscera
- Splanchnics (abdominopelvic cavity): preganglionic neuron in lateral ventral horn spinal cord => anterior root => spinal nerve => white ramus communicans => paired paravertebral ganglia (no synapse and same level/up/down the spinal cord) => splanchnic nerve exiting the paravertebral ganglion => synapse in unpaired prevertebral ganglion => postganglionic neuron => viscera
Are there more white or gray rami? Why?
Gray because you only need a white rami at the T1-L2 segment of the spinal cord but gray rami occur anywhere along the spinal cord
Describe the innervation pathway of the dilation of the pupil and relaxation of the ciliary muscle.
Hypothalamus => neurons to thoracic spinal cord => synapse on preganglionic neuron in lateral ventral horn of spinal cord => anterior root => spinal nerve => white ramus communicans => paravertebral ganglion => inferior cervical ganglion => synapse in superior cervical ganglion (paravertebral ganglion up the spinal cord) => postganglionic neuron => gray rami communicans => spinal nerve => anterior ramus => cephalic arterial branch of postganglionic neuron => carotid artery with periarterial plexus => dilator muscles and ciliary body
Are both pre and postganglionic nerves true splanchnic?
Only preganglionic
Are cardiopulmonary splanchnic nerves true splanchnics?
NOPE
Do sacral splanchnic preganglionic neurons come out of the sacral spinal cord?
NOPE, the thoracolumbar one and then travel down the paravertebral chain ganglion to the sacral spinal cord
What do we call the sacral parasympathetic preganglionic neurons?
Pelvic splanchnics
What are the only parasympathetic splanchnics?
Pelvic splanchnics
Describe the parasympathetic autonomic motor innervation pathway to the hindgut and pelvis.
Preganglionic neuron in ventral horn of sacral spinal cord (S2-S4) => anterior root => spinal nerve => pelvic splanchnics => unpaired prevertebral ganglion (no synapse) => synapse in intramural ganglion => postganglionic neuron => viscera
Describe the parasympathetic autonomic motor innervation pathway to the foregut and midgut.
Vagus nerve => synapse in intramural ganglion => postganglionic neuron => viscera
How many neurons from spinal cord involved in visceral motor innervation? What is the exception?
2: preganglionic and postganglionic neurons which synapse at ganglia
Exception: adrenal medulla composed of modified postganglionic neurons and innervated by preganglionic thoracic splanchnic sympathetic neurons
What are the 4 types of splanchnics and what do they each innervate? What kind of innervation does each provide?
- Thoracic (sympathetic): foregut and midgut of abdomen, adrenal glands, kidneys
- Lumbar (sympathetic): hindgut of abdomen, pelvis
- Sacral (sympathetic): pelvis
- Pelvic (parasympathetic): pelvis and hindgut
What do the posterior rami supply?
Back intrinsic muscles and skin covering them
What do the anterior rami supply?
Limbs and ventral portion of the body
What are 3 other names for the sympathetic chain ganglia?
- Paravertebral ganglia
- Paravertebral trunks
- Sympathetic ganglia
Other name for preganglionic neurons?
First-order neurons
Where do the parasympathetic preganglionic neurons synapse along the spinal cord? What do we call this?
- Cranial nerve nuclei (III, VII, IX, X)
- S2 to S4 spinal segments (sacral spinal cord)
Craniosacral outflow
Do sacral splanchnic preganglionic neurons come out of the sacral spinal cord?
NOPE, the thoracolumbar one and then travel down the paravertebral chain ganglion to the sacral spinal cord
Where do the sympathetic preganglionic neurons synapse along the spinal cord? What do we call this?
T1 to L2 spinal segments = thoracolumbar outflow
Sympathetic pathway to the periphery?
Preganglionic neuron in lateral ventral horn of spinal cord => anterior root => spinal nerve => white ramus communicans => synapse paravertebreal ganglion (up/down or same level of spinal cord) => postganglionic neuron in grey ramus communicans => spinal nerve => anterior or posterior ramus
What is sudomotion?
Actions of sympathetic nerves that stimulate the sweat glands to activity
What is meant by divergence of the sympathetic NS?
4 possible courses taken by presynaptic fibers within the sympathetic trunks:
- Ascend and then synapse
- Synapse at level of entry
- Descend and then synapse
- Pass through sympathetic trunk without synapsing to enter abdominopelvic splanchnic nerves
How will the regions that can’t be innervated by the vagus nerve be parasympathetically innervated? What are these 2 regions?
Parasympathetic splanchnic nerves in the sacral spinal cord (S2-S4)
Hindgut and pelvis
Where does vagus nerve innervation start and end?
Starts at foregut and ends after midgut at the left colic flexure (aka where transverse colon becomes the descending colon)
What is the parasympathetic NS concerned with?
Preserving energy
Describe the parasympathetic NT pathway.
Preganglionic neuron releases ACh => postganglionic nicotinic receptors leading to ACh release => target structure muscarinic receptors => inhibition or excitation of target structure
How can parasympathetic innervation on a target structure lead to either inhibition or activation? Example?
Muscarinic receptors can have different effects depending on location
Example:
- Heart is inhibited via hyperpolarization leading to bradycardia
- Digestive tract smooth muscle is excited by depolarization leading to contractions
Describe the sympathetic NT pathway.
Preganglionic neuron releases ACh => postganglionic nicotinic receptors leading to NE release => target strcuture adrenergic receptors
Does the parasympathetic NS innervate the skin?
NOPE
Why are the white rami communicans white?
Because preganglionic MYELINATED fibers go through them
Why are the grey rami communicans grey?
Because postganglionic UNMYELINATED fibers go through them
Can the effect of the ACh release by sympa and parasympa preganglionic neurons be either excitatory or inhibitory?
NOPE, always excitatory
Describe the pathway of the innervation of the adrenal medulla.
Preganglionic neuron in lateral ventral horn T5 to T9 spinal cord => anterior root => spinal nerve => white ramus communicans => paravertebral ganglion (no synapse) => greater thoracic splanchnic nerve exits => unpaired prevertebral ganglion (no synapse) => synapse on adrenal medulla => release of NE and EPI
Other name for prevertebral ganglion?
Collateral ganglion
Differences between paravertebral and prevertebral ganglia?
Paravertebral are right next to spinal cord and paired
Prevertebral are further from spinal cord and unpaired
What are the 7 major effects produced by sympathetic post-ganglionic fibers that travel in spinal nerves (posterior and anterior rami)?
- Constriction of cutaneous blood vessels and reduction in circulation to the skin (making it cold) as well as to most other organs in body wall
- Acceleration of blood flow to skeletal muscles
- Stimulation of energy production and use by skeletal muscle tissue
- Release of stored lipids from subcutaneous adipose tissue
- Dilation of the pupils to allow more light int the eyes and focusing of the eyes to view distant objects
- Stimulation of arrector pili muscles, producing goose bumps
- Stimulation of skin sweat glands
What kind of innervation do visceral plexuses receive?
Both sympathetic and parasympathetic
What is an example of a visceral plexus?
Plexus on the aorta from splanchnic nerve innervation = prevertebral plexus
What are the 4 major effects produced by sympathetic cardiopulmonary nerves/splanchnics entering the thoracic cavity?
- Accelerating the heart rate and increasing the strength of cardiac contractions
- Dilating coronary vessels
- Dilating of the respiratory passageways
- Inhibiting muscles and glands of the esophagus
Reaction of the heart when sympathetically stimulated?
Works harder => circulating blood at a higher rate and under increased pressures
Reaction of air flow when sympathetically stimulated?
Air flow is more efficient => improved delivery of O2 and elimination of CO2
What are the 3 types of thoracic sympathetic splanchnics? From what portion of the spinal cord does each exit from?
- Greater splanchnics: T5 to T9
- Lesser splanchnics: T9 to T11
- Least splanchnics: T12
From what portions of the spinal cord do sympathetic cardiopulmonary nerves/splanchnics exit the paravertebral ganglia?
- Cervical spinal cord
- T1 to T6
From what portions of the spinal cord do sympathetic autonomic motor neurons to the peripheral parts of the body exit from exit the paravertebral ganglia?
- C1/C2 to C8
- T1 to Co
From what portions of the spinal cord do sympathetic lumbar splanchnics exit from?
L1 to L2