Lecture 8 - Anatomy of the Autonomic System Flashcards

1
Q

What would happen to a body if we removed all consciousness?

A

All physiological processes would continue virtually unchanged because of the ANS (consciousness only represents a tiny fraction of the activities of the NS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

10 functions of ANS?

A
  1. Regulates body temp
  2. Coordinates CV function
  3. Coordinates respiratory function
  4. Coordinates digestive function
  5. Coordinates excretory function
  6. Coordinates reproductive function
  7. Adjusts internal water
  8. Adjusts fluid electrolytes
  9. Adjusts nutrients in tissue fluids
  10. Adjusts dissolved gas concentrations in bodily fluids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Other name for ANS?

A

Visceral motor NS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which special sense is considered a visceral sensory?

A

Taste

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What 5 general senses are part of the visceral sensory division of the NS?

A
  1. Stretch
  2. Pain
  3. Temperature
  4. Chemical changes
  5. Irritation of viscera
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What 3 tissues does the ANS innervate?

A
  1. Smooth muscle
  2. Cardiac muscle
  3. Glands
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the 2 main differences between the somatic efferent pathway and the autonomic pathway?

A
  1. LMNs of the SNS synapse directly onto skeletal muscle allowing for precise innervation vs autonomic pathways involve 2 neurons (CNS + PNS) and is diffuse with divergent targeting and indirect control
  2. LMNs are heavily myelinated therefore have faster conduction vs ANS preganglionic neurons are slightly myelinated and postganglionic ones are not at all, therefore have slower conduction
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Is ANS conduction faster in the preganglionic or postganglionic nerve?

A

Preganglionic because slightly myelinated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where are the autonomic preganglionic neuron bodies found? 2 names

A

Intermediolateral cell column of spinal cord = lateral horns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Parasympathetic NS: how does the length of the preganglionic neuron compare to the postganglionic neuron? Why?

A

Longer preganglionic neuron because intramural ganglia are in the walls of the target organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Sympathetic NS: how does the length of the preganglionic neuron compare to the postganglionic neuron? Why?

A

Longer postganglionic neuron because paravertebral and prevertebral ganglia are close to spinal cord

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the 3 autonomic ganglia of the PNS?

A
  1. Paravertebral (chain) ganglia
  2. Prevertebral ganglia
  3. Intramural ganglia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Describe the organization of the spinal nerves.

A

Rootlets => dorsal/ventral roots => spinal nerves => dorsal/ventral rami

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Describe the 2 sympathetic autonomic motor innervation pathways to viscera. What does each innervate?

A
  1. Cardiopulmonary nerves/splanchnics (thoracic cavity): preganglionic neuron in lateral ventral horn of spinal cord => anterior root => spinal nerve => white ramus communicans => synapse in paired paravertebral ganglia (same level/up/down the spinal cord) => postganglionic neuron (cardiopulmonary nerves) => viscera
  2. Splanchnics (abdominopelvic cavity): preganglionic neuron in lateral ventral horn spinal cord => anterior root => spinal nerve => white ramus communicans => paired paravertebral ganglia (no synapse and same level/up/down the spinal cord) => splanchnic nerve exiting the paravertebral ganglion => synapse in unpaired prevertebral ganglion => postganglionic neuron => viscera
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Are there more white or gray rami? Why?

A

Gray because you only need a white rami at the T1-L2 segment of the spinal cord but gray rami occur anywhere along the spinal cord

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Describe the innervation pathway of the dilation of the pupil and relaxation of the ciliary muscle.

A

Hypothalamus => neurons to thoracic spinal cord => synapse on preganglionic neuron in lateral ventral horn of spinal cord => anterior root => spinal nerve => white ramus communicans => paravertebral ganglion => inferior cervical ganglion => synapse in superior cervical ganglion (paravertebral ganglion up the spinal cord) => postganglionic neuron => gray rami communicans => spinal nerve => anterior ramus => cephalic arterial branch of postganglionic neuron => carotid artery with periarterial plexus => dilator muscles and ciliary body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Are both pre and postganglionic nerves true splanchnic?

A

Only preganglionic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Are cardiopulmonary splanchnic nerves true splanchnics?

A

NOPE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Do sacral splanchnic preganglionic neurons come out of the sacral spinal cord?

A

NOPE, the thoracolumbar one and then travel down the paravertebral chain ganglion to the sacral spinal cord

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What do we call the sacral parasympathetic preganglionic neurons?

A

Pelvic splanchnics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are the only parasympathetic splanchnics?

A

Pelvic splanchnics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Describe the parasympathetic autonomic motor innervation pathway to the hindgut and pelvis.

A

Preganglionic neuron in ventral horn of sacral spinal cord (S2-S4) => anterior root => spinal nerve => pelvic splanchnics => unpaired prevertebral ganglion (no synapse) => synapse in intramural ganglion => postganglionic neuron => viscera

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Describe the parasympathetic autonomic motor innervation pathway to the foregut and midgut.

A

Vagus nerve => synapse in intramural ganglion => postganglionic neuron => viscera

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

How many neurons from spinal cord involved in visceral motor innervation? What is the exception?

A

2: preganglionic and postganglionic neurons which synapse at ganglia

Exception: adrenal medulla composed of modified postganglionic neurons and innervated by preganglionic thoracic splanchnic sympathetic neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What are the 4 types of splanchnics and what do they each innervate? What kind of innervation does each provide?

A
  1. Thoracic (sympathetic): foregut and midgut of abdomen, adrenal glands, kidneys
  2. Lumbar (sympathetic): hindgut of abdomen, pelvis
  3. Sacral (sympathetic): pelvis
  4. Pelvic (parasympathetic): pelvis and hindgut
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What do the posterior rami supply?

A

Back intrinsic muscles and skin covering them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What do the anterior rami supply?

A

Limbs and ventral portion of the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What are 3 other names for the sympathetic chain ganglia?

A
  1. Paravertebral ganglia
  2. Paravertebral trunks
  3. Sympathetic ganglia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Other name for preganglionic neurons?

A

First-order neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Where do the parasympathetic preganglionic neurons synapse along the spinal cord? What do we call this?

A
  1. Cranial nerve nuclei (III, VII, IX, X)
  2. S2 to S4 spinal segments (sacral spinal cord)

Craniosacral outflow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Do sacral splanchnic preganglionic neurons come out of the sacral spinal cord?

A

NOPE, the thoracolumbar one and then travel down the paravertebral chain ganglion to the sacral spinal cord

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Where do the sympathetic preganglionic neurons synapse along the spinal cord? What do we call this?

A

T1 to L2 spinal segments = thoracolumbar outflow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Sympathetic pathway to the periphery?

A

Preganglionic neuron in lateral ventral horn of spinal cord => anterior root => spinal nerve => white ramus communicans => synapse paravertebreal ganglion (up/down or same level of spinal cord) => postganglionic neuron in grey ramus communicans => spinal nerve => anterior or posterior ramus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What is sudomotion?

A

Actions of sympathetic nerves that stimulate the sweat glands to activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What is meant by divergence of the sympathetic NS?

A

4 possible courses taken by presynaptic fibers within the sympathetic trunks:

  1. Ascend and then synapse
  2. Synapse at level of entry
  3. Descend and then synapse
  4. Pass through sympathetic trunk without synapsing to enter abdominopelvic splanchnic nerves
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

How will the regions that can’t be innervated by the vagus nerve be parasympathetically innervated? What are these 2 regions?

A

Parasympathetic splanchnic nerves in the sacral spinal cord (S2-S4)

Hindgut and pelvis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Where does vagus nerve innervation start and end?

A

Starts at foregut and ends after midgut at the left colic flexure (aka where transverse colon becomes the descending colon)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

What is the parasympathetic NS concerned with?

A

Preserving energy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Describe the parasympathetic NT pathway.

A

Preganglionic neuron releases ACh => postganglionic nicotinic receptors leading to ACh release => target structure muscarinic receptors => inhibition or excitation of target structure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

How can parasympathetic innervation on a target structure lead to either inhibition or activation? Example?

A

Muscarinic receptors can have different effects depending on location

Example:

  • Heart is inhibited via hyperpolarization leading to bradycardia
  • Digestive tract smooth muscle is excited by depolarization leading to contractions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Describe the sympathetic NT pathway.

A

Preganglionic neuron releases ACh => postganglionic nicotinic receptors leading to NE release => target strcuture adrenergic receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Does the parasympathetic NS innervate the skin?

A

NOPE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Why are the white rami communicans white?

A

Because preganglionic MYELINATED fibers go through them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Why are the grey rami communicans grey?

A

Because postganglionic UNMYELINATED fibers go through them

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Can the effect of the ACh release by sympa and parasympa preganglionic neurons be either excitatory or inhibitory?

A

NOPE, always excitatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Describe the pathway of the innervation of the adrenal medulla.

A

Preganglionic neuron in lateral ventral horn T5 to T9 spinal cord => anterior root => spinal nerve => white ramus communicans => paravertebral ganglion (no synapse) => greater thoracic splanchnic nerve exits => unpaired prevertebral ganglion (no synapse) => synapse on adrenal medulla => release of NE and EPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Other name for prevertebral ganglion?

A

Collateral ganglion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Differences between paravertebral and prevertebral ganglia?

A

Paravertebral are right next to spinal cord and paired

Prevertebral are further from spinal cord and unpaired

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

What are the 7 major effects produced by sympathetic post-ganglionic fibers that travel in spinal nerves (posterior and anterior rami)?

A
  1. Constriction of cutaneous blood vessels and reduction in circulation to the skin (making it cold) as well as to most other organs in body wall
  2. Acceleration of blood flow to skeletal muscles
  3. Stimulation of energy production and use by skeletal muscle tissue
  4. Release of stored lipids from subcutaneous adipose tissue
  5. Dilation of the pupils to allow more light int the eyes and focusing of the eyes to view distant objects
  6. Stimulation of arrector pili muscles, producing goose bumps
  7. Stimulation of skin sweat glands
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

What kind of innervation do visceral plexuses receive?

A

Both sympathetic and parasympathetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

What is an example of a visceral plexus?

A

Plexus on the aorta from splanchnic nerve innervation = prevertebral plexus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

What are the 4 major effects produced by sympathetic cardiopulmonary nerves/splanchnics entering the thoracic cavity?

A
  1. Accelerating the heart rate and increasing the strength of cardiac contractions
  2. Dilating coronary vessels
  3. Dilating of the respiratory passageways
  4. Inhibiting muscles and glands of the esophagus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Reaction of the heart when sympathetically stimulated?

A

Works harder => circulating blood at a higher rate and under increased pressures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Reaction of air flow when sympathetically stimulated?

A

Air flow is more efficient => improved delivery of O2 and elimination of CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

What are the 3 types of thoracic sympathetic splanchnics? From what portion of the spinal cord does each exit from?

A
  1. Greater splanchnics: T5 to T9
  2. Lesser splanchnics: T9 to T11
  3. Least splanchnics: T12
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

From what portions of the spinal cord do sympathetic cardiopulmonary nerves/splanchnics exit the paravertebral ganglia?

A
  • Cervical spinal cord

- T1 to T6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

From what portions of the spinal cord do sympathetic autonomic motor neurons to the peripheral parts of the body exit from exit the paravertebral ganglia?

A
  • C1/C2 to C8

- T1 to Co

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

From what portions of the spinal cord do sympathetic lumbar splanchnics exit from?

A

L1 to L2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

From what portions of the spinal cord do sympathetic sacral splanchnics exit from?

A

L1 to L2

60
Q

How do the sympathetic splanchnics usually travel after they exit the paravertebral ganglion?

A

They piggy-back on arteries to travel to target organs

61
Q

What are the 7 major effects produced by sympathetic splanchnics that innervate collateral ganglia?

A
  1. Constricting small arteries and reducing flow of blood to visceral organs
  2. Decreasing the activity of digestive glands and organs, including the stomach, intestines, pancreas, and gallbladder
  3. Stimulating the release of glucose from the liver’s glycogen reserves
  4. Stimulating the release of lipids from adipose tissue
  5. Reducing the rate of urine formation in the kidneys
  6. Relaxing the smooth muscle in the wall of the urinary bladder
  7. Controlling some aspects of sexual function (e.g. ejaculation in males)
62
Q

Timing of effect of NE and EPI release?

A

Order of minutes

63
Q

Timing of effects of sympathetic splanchnics that innervate collateral ganglia?

A

Quick

64
Q

Timing of effects of sympathetic post-ganglionic fibers that travel in spinal nerves (posterior and anterior rami)?

A

Quick

65
Q

Timing of effects of sympathetic cardiopulmonary nerves/splanchnics?

A

Quick

66
Q

3 locations of parasympathetic cranial nuclei?

A
  1. Mesencephalon
  2. Pons
  3. Medulla
67
Q

Where are parasympathetic intramural ganglia located?

A

Within or adjacent to the target organs

68
Q

Which are more divergent: sympathetic or parasympathetic preganglionic neurons? Explain

A

Sympathetic ones

Parasympathetic postganglionic neurons synapsing with one preganglionic neuron usually are all located in the same intramural ganglion and thus influence the same target organs => more specific and localized effect

69
Q

With how many postganglionic neurons does a typical parasympathetic preganglionic neuron synapse with?

A

6-8

70
Q

Other name for postganglionic neurons?

A

Second order neurons

71
Q

Is there any parasympathetic output to limbs and skin?

A

NOPE

72
Q

What are the 9 major effects produced by the parasympathetic division of the ANS?

A
  1. Constriction of the pupils to restrict the amount of light entering eyes, and focusing on
    nearby objects
  2. Secretion by digestive glands, including salivary glands, gastric glands, duodenal glands,
    intestinal glands, pancreas, and liver
  3. Secretion of hormones that promote nutrient absorption by peripheral cells
  4. Increased smooth muscle activity along the digestive tract
  5. Stimulation and coordination of defecation
  6. Contraction of the urinary bladder during urination
  7. Constriction of the respiratory passageways
  8. Reduction in heart rate and force of contraction
  9. Sexual arousal and stimulation of sexual glands in both sexes
73
Q

Where are visceral sensory fibers usually found? Exception?

A

Accompany visceral motor fibers and enter spinal cord at similar spinal cord levels

Exception: heart sensory

74
Q

What sensation do sympathetic sensory fibers carry?

A

Generally pain

75
Q

Which parasympathetic nerve fibers carry pain sensations?

A

Cranial nerves IX and X

76
Q

Which ANS neurons participate in visceral reflexes?

A

Preganglionic neurons in lower brain stem and spinal cord

77
Q

What are the simplest functional units of the ANS?

A

Visceral reflexes

78
Q

What CNS structure is the one that mainly modifies, facilitates or inhibits visceral reflexes? What other brain structures do this?

A

Hypothalamus

Others:

  • Brain stem
  • Spinal cord
  • Amygdala
  • Cerebral cortex
79
Q

What are the 9 parasympathetic reflexes?

A
  1. Gastric and intestinal reflexes
  2. Defecation
  3. Urination
  4. Light and consensual light reflexes
  5. Swallowing reflex
  6. Vomiting reflex
  7. Coughing reflex
  8. Cardioinhibitory reflex
  9. Sexual arousal
80
Q

What are the 4 sympathetic reflexes?

A
  1. Cardioacceleratory reflex
  2. Vasomotor reflex
  3. Pupillary reflex
  4. Ejaculatory reflex (in males)
81
Q

What is the point and shoot innervation of the penis?

A
  1. Point => parasympathetic => erection

2. Shoot => sympathetic => ejaculation

82
Q

Difference in size between sympathetic and parasympathetic ganglia?

A

Sympa: large
Parasympa: invisible to naked eye

83
Q

Which is more complex: sympa or parasympa?

A

Sympa

84
Q

Which innervates more organs: sympa or parasympa?

A

Sympa

85
Q

What needs to be removed to be able to see the sympathetic trunk ganglia in a dissection?

A

Parietal pleura of the lungs

86
Q

What do the sympathetic trunk ganglia attach to?

A
  1. Spinal cord

2. Intercostal nerve

87
Q

How many sympathetic trunk ganglia are there?

A

Approximately one for each spinal nerve, but some fuse, especially in the head (up to 7)

88
Q

How are prevertebral ganglia formed?

A

Fusion of paravertebral ganglia

89
Q

Where are prevertebral ganglia found?

A

Abdomen and pelvis, anterior to the vertebral column

90
Q

What do prevertebral ganglia look like?

A

Thick connective tissue, almost like cartilage

91
Q

What are the 3 major effects produced by sympathetic nerves to the head?

A
  1. Inhibit lacrimal, nasal, and salivary glands (i.e. dry mouth)
  2. Stimulate eye muscles that dilate iris, and adapt to far vision
  3. Stimulate eyelid muscles to keep them open
92
Q

How does the pathway of the thoracic cardiopulmonary sympathetic splanchnics vary between the heart and lungs? How did this discovery affect heart transplants?

A
  • Lungs: exit spinal cord at same level as the parasympathetic chain ganglia
  • Heart: travel to cervical sympathetic ganglion => they used to cut both the old and donor hearts through right atrium and reattach the new heart to a portion of the old RA so that the nerve supply would stay intact, hoping it would regrow around the new heart.

However, this does not work (HA!) so now we just transplant the full heart and give it a pacemaker

93
Q

What parts of the body does the parasympathetic cranial output innervate?

A
  1. Head
  2. Neck
  3. Thorax
  4. Foregut/midgut
94
Q

What 5 plexuses does the vagus nerve innervate?

A
  1. Cardiac
  2. Pulmonary plexus
  3. Esophageal plexus
  4. Celiac plexus
  5. Superior mesenteric plexus
95
Q

Other name for left colic flexure?

A

Splenic flexure

96
Q

What does the celiac plexus innervate?

A
  1. Liver
  2. Gallbladder
  3. Stomach
  4. Spleen
  5. Pancreas
97
Q

What plexus do the parasympathetic splanchnic nerves form in the hindgut?

A

Hypogastric plexus

98
Q

Why is it important the the parasympathetic NS is not as divergent as the sympathetic one?

A

Responsible for excretion (urination and defecation) AND reproduction and that needs to be discretely innervated

99
Q

Other word for erection?

A

Erectile tumescence

100
Q

What does the brain do once it receives visceral sensory information?

A

It interprets it as hunger, fullness, pain, nausea, or well-being

101
Q

Are visceral sensations easy to localize with precision?

A

NOPE

102
Q

Does a patient experience pain when his visceral organs are cut or scraped?

A

NOPE

103
Q

Are somatic sensations easy to localize with precision?

A

YUP

104
Q

What is a sharp pain?

A

Somatic pain relating to the parietal wall (because it has somatic sensory receptors)

105
Q

What is a dull pain?

A

Visceral pain

106
Q

What is referred pain? What is it due to?

A

Visceral pain perceived as originating from the skin or outer body (as somatic pain)

May be due to reflexive vasoconstriction in the vessels supplying the corresponding somatic segments

107
Q

Why does the referred pain of the heart extends to the medial arm?

A

Because intercostal nerve T2 which becomes the brachial nerve exits the spinal cord at the same level as the visceral afferents from the heart

108
Q

Describe the pathway of a visceral reflex arc.

A

Sensory receptor in viscera => visceral sensory fiber => dorsal root ganglion => dorsal root => dorsal horn of spinal cord => synapse with preganglionic neuron at integration center of the spinal cord => preganglionic neuron exits spinal cord and synapses at one of the autonomic ganglia => postganglionic neuron synapse on organ

109
Q

Do visceral reflexes have the same basic components as somatic reflexes?

A

Yes, but all visceral reflexes are polysynaptic (involve an interneuron)

110
Q

What is the enteric NS?

A

Complete 3 neuron reflex arc that exist entirely within the wall of the digestive tube

111
Q

Do both urination and defecation require voluntary relaxation of sphincters?

A

YUP

112
Q

Stimulus and response of cardioinhibitory parasympathetic reflex?

A
  • Stimulus: sudden rise in BP in carotid artery

- Response: reduction in heart rate and force of contraction

113
Q

Where are the ANS cardiac reflexes coordinated?

A

Cardiac center of medulla oblongata

114
Q

Stimulus and response of cardioacceleratory sympathetic reflex?

A
  • Stimulus: sudden decline in BP in carotid artery

- Response: increase in heart rate and force of contraction

115
Q

Stimulus and response of vasomotor sympathetic reflex?

A
  • Stimulus: changes in BP in major arteries

- Response: changes in diameter of peripheral vessels to maintain normal range of BPs

116
Q

Where are the sympathetic vasomotor reflexes coordinated?

A

Vasomotor center of medulla oblongata

117
Q

Can you consciously regulate the ANS?

A

YUP

118
Q

What are 2 examples of the conscious regulation of the ANS?

A
  1. Waiting to pee

2. Cheating a lie detector test

119
Q

What brain structure mediates communication between the cerebral cortex and the hypo?

A

Limbic system

120
Q

What is hyperpyrexia? 2 other names?

Treatment?

A

Dilated veins in the face in response to stress/sympathetic stimulation

= red burning face = facial blushing

Treatment = ablate the sympathetic nerves innervating the facial veins

121
Q

What are the ONLY veins in the body that respond to sympathetic innervation BY DILATING?

A

Facial veins

122
Q

What is hyperhidrosis? Diagnostic test? Treatments?

A

Overactive sympathetic NS causing excessive sweating of the hands

Test = place mixture of starch, alizarin red, and sodium carbonate on palms and elevate patient’s core temperature - indicator color will go from light orange to purple if positive

Treatments =

  1. Bilateral endoscopic thoracic sympathectomy (ETS): ablate the sympathetic trunk at T3/T4 (but risk of many complications because have to cause pneumothorax to reach the sympathetic chain aka pierce the pleura and compensatory sweating in other places like the back)
  2. Botox injections in armpits ever 3/4 months to eliminate autonomic nerves to the hands
123
Q

What % of the Asian population has hyperhidrosis?

A

20%

124
Q

Describe the embryonic development of sympathetic structures.

A

Specialized neural crest cells migrate to prevertebral ganglia and then settle in GIT

125
Q

What is Hirschsprung’s disease? Treatment?

A

Neural crest cells destined for the GIT fail to migrate during embryonic development causing a genetic birth defect where parasympathetic innervation of the distal end of the colon fails to develop => feces and gas accumulate proximal to the affected bowel segment causing tremendous distention/hypertrophy of the bowels

Treatment = surgery to remove that part of the colon

126
Q

What is Reynaud’s disease? Cause? Treatment

A

Intermittent attacks during which skin of fingers and toes becomes pale and then blue (cyanotic) and painful due to exposure to cold and emotional stress (after attacks the vessels fill with blood again)

Cause = exaggerated sympathetic vasoconstriction response in affected regions

Treatment = drugs that inhibit vasoconstriction but severe cases may require ganglia removal

127
Q

Describe the severity of Reynaud’s disease.

A

Varies

128
Q

Potential complication of Reynaud’s disease?

A

Gangrene

129
Q

% of elderly affected by Reynaud’s disease?

A

9% elderly women

3-5% elderly men

130
Q

Why do vessels of extremities constrict when we are cold?

A

To make sure our core and brain are not cold

131
Q

What is HT brought on by?

A

Overactive sympathetic vasoconstriction from continual stress

132
Q

2 complications of HT?

A
  1. Increases work load on heart, possibly precipitating heart attack
  2. Increases wear/tear on vessels
133
Q

Stress induced HT treatment?

A

Drugs that inhibit binding of NE and EPI to smooth muscle cells of blood vessels

134
Q

What is achalasia? Diagnosis? Treatment?

A

Impaired autonomic innervation of esophagus resulting in loss of ability to propel food inferiorly and food cannot enter the stomach

Diagnosis: barium orally for imaging

Treatment = longitudinal incision through muscle at inferior end of esophagus OR dilation of lower esophageal sphincter with a balloon

135
Q

Do beta-adrenergic receptors play a role in vasoconstriction?

A

NOPE

136
Q

Receptors for vasoconstriction?

A

Alpha adrenergic

137
Q

To what 3 plexuses do the sympathetic sacral splanchnics go to?

A
  1. Inferior mesenteric
  2. Aortic
  3. Hypogastric
138
Q

To what 2 plexuses do the sympathetic thoracic and lumbar (abdominal) splanchnics go to?

A
  1. Aortic

2. Superior mesenteric

139
Q

Other name for sympathetic thoracic and lumbar splanchnics?

A

Abdominal sympathetic splanchnics

140
Q

What do we call the intramural parasympathetic ganglion where the pre and postganglionic neurons synapse going to the parotid gland?

A

Otic ganglion

141
Q

What do we call the intramural parasympathetic ganglion where the pre and postganglionic neurons synapse going to the submandibular and sublingual glands?

A

Submandibular ganglion

142
Q

What do we call the intramural parasympathetic ganglion where the pre and postganglionic neurons synapse going to the lacrimal and nasal glands?

A

Pterygopalatine ganglion

143
Q

What 4 organs does the hypogastric plexus innervate?

A
  1. Large intestine (para only)
  2. Rectum (para only)
  3. Urinary bladder + ureters
  4. Sex organs
144
Q

Is the vagus nerve a pre or postganglionic nerve?

A

Preganglionic

145
Q

What kind of thoracic splanchnic innervates the adrenal glands?

A

Greater thoracic splanchnic