lecture 8 Flashcards
How is EM radiation sensed by the body?
Receptor: rod and cone photoreceptors
Range: 400 to 600nm wavelength
Sensitivity and dynamic range: single photo to bright sunlight (10^10 fold)
Receptive field: single photoreceptor, concentric ganglion cell
How is distortion of the skin sensed by the body?
Receptor: various encapsulated nerve endings
Range: 10nm to sub-damaging distortion
Sensitivity and dynamic range: mg, 0-1000 Hx
Receptive field: ovaloid from 10mm^2 to entire hand
What does the somatosensory system do?
- mediates sensations from the whole body surface, including skin and deeper tissues
What is the structure of skin?
- most of the body is covered by hairy skin
- the palmar surface of the hands and the soles of the feet are covered by glabrous skin, with skin ridges a prominent feature
Give an overview of the somatosensory system.
- There are four types of mechanoreceptors in glabrous skin
- Meissner corpuscles and Merkel complexes are close to the surface
- Ruffini organs and Pacinian corpuscles are deeper in the skin
- These receptors are innervated by large myelinated axons with cell bodies in the dorsal root ganglia
- Transmission of this information to the brain generates our conscious experience of touch
What are the layers of the skin?
- top dead layer
- epidermis
- dermis
- subcutaneous layer
Where are free nerve endings located?
epidermis
Where are Meissner corpuscles located?
right below the epidermis in the upper part of the dermis
Where are Merkel cell-neutrite complexes located?
In the deep grooves of the epidermis
Where are Ruffini corpuscles located?
dermis
Where are Pacinian corpuscles located?
Dermis/subcutaneous layer
What do Ruffini corpuscles respond to?
Skin being moved or stretched
What do Pacinian corpuscles respond to?
Vibration
How do these mechanoreceptors open sodium channels?
Thought to be literally by force - movement/pressure/whatever that receptor responds to opens the gate and allows the movement of sodium ions across the membrane leading to depolarisation
- however there is greater molecular complexity to it - resistance from ECM and inside of cell
What is the key event for generating an action potential?
depolarisation
What is a crucial difference between the mechanoreceptors?
- how they respond to an ongoing stimulus
How can we talk about stimuli in general?
We can talk about stimuli as causing a transient change or a sustained change. Mechanoreceptors in turn can adapt slowly to a stimulus, or they can adapt rapidly.
Do cells tend adapt rapidly or slowly?
Rapidly - prefer to detect changes. When things stay the same it doesn’t really tell us anything worth knowing e.g. clothes throughout the day
What are the slowly adapting mechanoreceptors?
Merkel:
- complexes are found at the troughs of the epidermal ridges where they respond to indentation
Ruffini:
- endings are found in the upper dermis, have a sustained response to skin movement
What are the rapidly adapting mechanoreceptors?
Meissner:
- receptors are found near the skin surface and have a transient response to skin movement.
Pacinian:
- receptors are located deep in the dermis and hypodermis and have a transient response to vibration
What is the distribution/, receptor field of the different mechanoreceptors in the palm of the hand?
- Merkel: 25% of total, smallest RF
- Meissner: 40% of total, still a small receptor field
- Ruffini: 20%, “proprioceptive”, larger receptor fields
- Pacinian: 15% , most sensitive, vibrations, huge receptor fields
Where else are mechanoreceptors located?
- in the muscle: spindles
- in the tendons: golgi tendon organ
- they are activated by physical deformation forces
- they signal information about muscle stretch or position and tendon force
- not considered part of somatosensation
What are receptive fields?
- it’s really about what the system can do
- resolution
- how sensitive/the smallest difference it can detect
- depending on how centrally in a particular receptive field something is acting, the associated receptor will respond strongly or weakly
- the closest together to points of contact can be while still detecting that it is two points of contact is a way you can define resolution.
- e.g. fingertips = a few mm, thigh = a few cm
What do all four somatosensory mechanoreceptors connect to?
- afferent axon type = A-Beta fibres
- 6 - 12 µm diameter
- 33 - 75 m/s
- large and myelinated