lecture 31 Flashcards

1
Q

What else does our big brain do?

A

much of our conscious mental activity relates to abstraction

  • analysis - how things work
  • calculation and estimation
  • planning
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2
Q

How can we break prefrontal cortex down anatomically?

A
  • dorsolateral region
  • orbital
  • medial
  • medial and orbital more associated with social cognition
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3
Q

What is the function of the dorsolateral prefrontal cortex?

A

working memory:

  • remembering a phone number
  • remembering and applying rules (count backwards from 100 in steps of 7)

memory of the future

  • delayed gratification, plans, goals
  • temporal structuring of behaviour
  • dorsolateral pfc damage: distractability, impulsiveness, perseverative errors
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4
Q

Is language controlled by prefrontal cortex?

A
  • no
  • language is the servant of intellect
  • auditory cortex
  • motor cortex
  • wernicke’s area
  • angular gyrus
  • broca’s area

all of these are not prefrontal

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5
Q

What is the border between prefrontal and complex motor association areas?

A
  • kind of frontal eye fields
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6
Q

What do we attend to mostly when looking at faces?

A
  • sharp angles of eyes and mouth

- this is where we get a lot of nonverbal communication from

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7
Q

What does prefrontal cortex examine?

A
  • what’s important immediately and in the future

- salience of our environment

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8
Q

What are higher order inferences?

A
  • categorisation, multiple regression, principle components (huge numbers of variables, what’s actually going on?)
  • the meaning of proverbs
  • word similiarity, word meaning (definition)
  • estimates
  • list words beginning with…
  • females tend to be better at this sort of thing
  • males tend to be better and spatial recognition - are these two shapes the same?
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9
Q

What is the standard stroop task?

A
  • read words - colours, but they are coloured differently
  • blue written in green
  • red written in brown wtc
  • task: ‘name the ink colour as fast as possible’

stard result
- incongruent slows compared with congruent condition (because word meaning interferes with colour naming on incongruent trials)

emotional stroop task

  • emotion condition vs neutral condition
  • anxious participants: emotion condition slowed cf neutral condition
  • non-axious participants: no difference
  • not necessarily prefrontal test
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10
Q

What is the wisconsin card sort?

A
  • measures the ability to change categorisation strategy
  • not told what the rule is - have to figure it out over time
  • categorisation rule is changed without telling you
  • tests ability of prefrontal cortex to restrategise when the strategy you’ve been using hasn’t been working
  • need flexibility to solve problems
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11
Q

What is the Tower of London/Hanoi task?

A
  • first becomes possible between 3 and 6
  • BA 10 is strongly activated during this type of task
  • this region is most conspicuously enlarged in humans compared to apes
  • as is our ability to plan into the future
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12
Q

Has the evolution of advanced social competencies - such as conceptualising the motivations of others - given rise to uniquely human functions?

A
  • no compelling evidence of “theory of mind”
  • the capicity of us to know what someone else knows
  • not yet seen in other species
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13
Q

How do we think?

A
  • what do we think about - getting what we want, understanding the way things work
  • predicition and control
  • curiosity is a defining characterstic of complex animals, seen to an extraordinary degree in humans
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14
Q

Why do we think so much? why do we explore? why not just “stay home”?

A
  • control
  • often we go beyond what’s required
  • drive to explore and to explain
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15
Q

What drives exploration and innoviation?

A
  • is it the need to find an advantage in the grim struggle for survival, or is it the bounty of excess?
  • in contrast to the commonly held assumption that competition drives innovation, the reverse may be trueL competition produces stasis. Only complacency drives change.
    “relaxed selection” prof. terrance deacon
  • the metabolically regulated enzyme sirtuin 1 (SIRT1) modulates monoamine oxidase A (MAO-A) levels to link mood and behavoir to energy consumption
  • variability in the SIRT1 gene contributes to human susceptibility to anxiety disorders
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16
Q

What is SIRT1?

A
  • the metabolically regulated enzyme sirtuin 1 (SIRT1) modulates monoamine oxidase A (MAO-A) levels to link mood and behavoir to energy consumption
  • variability in the SIRT1 gene contributes to human susceptibility to anxiety disorders
  • Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer: nature 2010
  • Sirt1 activates MAO-A in the brain to mediate anxiety and exploratory drive: cell 2011
  • A novel pathway regulates memory and plasticifty via SIRT1 and miR-134: nature 2010
  • “hungry, heaviy preyed-on animals would be best served by being anxious, vigilant, and carefuk, whereas well-fed mice should carelessly radiate and procreate”
17
Q

What is the purpose and mechanism of thinking?

A
  • understanding, problem solving
  • our most influential way of thinking is Science
  • science, succeeds in part by humanistic rejection of arbitrary authority, advocacy of personal liberty, and the “rigourous application of common sense”
18
Q

How do we think?

A
  • empirical methods
  • deductive methods
  • strategies, re-strategising - in the minds eye
  • modelling