Lecture 8

Question 1

Mitosis cycle

Answer 1

Prophase
Metaphase
Anaphase
Telophase

Question 2

Cell division cycle

Answer 2

24h, 1h for mitosis

Question 3

Haplodiploidy

Answer 3

Sex-determination system where males develop from unfertilized eggs and are haploid, and females develop from fertilized eggs and are diploid

Question 4

Spontaneous abortion, stillborn, live born

Answer 4

50%, 5%, 0.5%

Question 5

Autopolyploid

Answer 5

AAAA

Question 6

Allopolyploid

Answer 6

AABB

Question 7

Segmental allopolyploi

Answer 7

AAA’A’

Question 8

autoallopoplyploid

Answer 8

AAAABB

Question 9

paleopolyploid

Answer 9

AA

Question 10

Mitotic polyploidy

Answer 10

Formation of two tetraploid cells from a diploid mother cell (prophase x2)

Question 11

Parthenogenesis

Answer 11

Form of asexual reproduction in which growth and development of embryos occur without fertilization

Question 12

Variations in chromosome structure

Answer 12

• Deletion
• Duplication
• Inversion
• Translocation
• Ring

Question 13

Formation of Philadelphia chromosome

Answer 13

Translocation of 9 and 22

Question 14

Segregation at Meiosis after translocation

Answer 14

L pairing between homologous => Gamete depend on orientation separation

Question 15

Rx-Fish

Answer 15

Rainbow of colors, cross species FISH

Question 16

Technique to use depending on the issue

Answer 16

• Abnormality unknown and micro-alterations not suspected => Karyotyping => (Neg => FISH)
• Already described abnormalities and probes available => FISH => (Neg) SNP
• Abnormality unknown and suspected to be small/LOH => SNP Microarray

Question 17

Robertsonian translocation

Answer 17

Fusion 14/21, translocation carrier => Down syndrome 1/3