Lecture 8

Question 1

What is a pedigree?

Answer 1

pictorial representation of a family history, a family tree that outlines the inheritance of one or more characteristics

Question 2

What is a proband?

Answer 2

the person from who the pedigree is initiated

Question 3

Warenburg syndrome and traits

Answer 3

Autosomal dominant

deafness, fair skin, visual problems, white forelock

Question 4

Appears in both sexes with equal frequency

Answer 4

autosomal recessive traits

Question 5

trait tends to skip generations

Answer 5

autosomal recessive

Question 6

affected offspring are normally bored to unaffected parents

Answer 6

autosomal recessive , occurs more often in consanguineous marriages

Question 7

familial hypercholestrerolemia

Answer 7

• inherited disease in which cholesterol is greatly elevated due to cholesterol transport
• lipoproteins
• principal is LDL
• the receptor is defective

Question 8

familial hypercholesterolemia is?

Answer 8

incompletely dominant

Question 9

X linked recessive

Answer 9

-more males than females
- born to unaffected mother
-1/2 of carriers sons are affected
- never passes from father to son
-

Question 10

if both members of a twin pair express a trait

Answer 10

concordant

Question 11

if only one member of a twin pair expresses a trait

Answer 11

discordant

Question 12

genetically influenced traits should exhibit higher concordance in?

Answer 12

monozygotic twins

Question 13

concordance=

Answer 13

percentage of twin paris in which both members of the pair express the trait

Question 14

What is an example of a multifactorial trait?

Answer 14

obesity. … on inherits a predisposition twd a particular body weight
- leptin is produced in fat tissue and decreases apptetite by affecting the hypothalamus

Question 15

mating btw closing related ppl

Answer 15

consanguitity