Lecture 8 Flashcards
minerals
inorganic elements that retain their chemical identity (not destroyed by cooking or storing)
the trace minerals
- iodine
- iron
- zinc
- sulphur
- selenium
- fluoride
- chromium
- copper
iodine function
- integral part of thyroxine (hormone)
thyroxine
hormone made by thyroid gland
- regulation of basal metabolic rate
iodine deficiency symptoms
- enlarged thyroid (goiter)
- sluggishness
- weight gain
- severe deficiency during pregnancy can cause congenital hypothyroidism
goiter
enlarged thyroid to trap iodine
congenital hypothyroidism
- extreme irreversible mental and physical developmental delay
- most preventable causes of intellectual delay
what foods cause iodine deficiency?
collards, kate and brussel sprouts
- contain goitrogens which inhibit iodine uptake by thyroid
iodine toxicity
- enlarged thyroid glant
- can be deadly in very large amounts
sources of iodine
- seafood (from ocean)
- iodized salt
- amount varies with amount in soil in which plants are grown or on which animals graze
iodized salt
less than 1/2 tsp meets an entire days recommendation
sea salt and iodine
sea salt contains very little iodine
- dry all of it out and iodine is blown away
iron
essential nutrient and deficiency is problem for many
what contains most of the body’s iron?
hemoglobin and myoglobin
hemoglobin
oxygen-carrying protein of red blood cells
myoglobin
oxygen-holding protein of muscles
iron function
- carried oxygen
- helps many enzymes use oxygen
- needed to make new cells, amino acids, hormones and , neurotransmitters
iron storage and excretion
- liver puts iron into red blood cells sent from bone marrow
- RBCs die after 3-4 months and the liver and spleen break them down and recycle their iron
how is iron balance maintained?
through absorption
iron loss
- small amounts of iron is loss in nail clippings, hair cutting, shed skin cells
- loss of iron from bleeding can be significant
obtaining iron
only approx. 10-15% of iron is absorbed
1. absorption increases with diminished body supply and with need
2. absorption decreases when iron is abundant
ferritin
an iron storage where protein stores iron in the mucosal cells of small intestine
what happens when iron is needed?
iron is released to transferrin and travels through blood to body
what happens when iron is not needed?
iron is shed with the intestinal cells which are replaced every 3-5 days
free iron
powerful oxidant
- can start free-radical reactions that damages cells
iron deficiency
result of iron absorption not compensating for losses or low dietary intakes
decreased iron stores
stage I iron deficiency
depleted iron stores
stage II iron deficiency
iron deficiency anemia
depletion of iron stores resulting in low blood hemoglobin (stage 3 deficiency)
- people can be iron deficient without being anemic
anemia results
cells contain too little hemoglobin and thus deliver too little oxygen which limits cells metabolism
symptoms of anemia
- tiredness
- apathy
- a tendency to feel cold
what are symptoms of an iron deficiency often mistaken for?
behavioural or emotional problems
pica
craving non-food substances
- occurs with iron deficiency sometimes
- inhibit iron absorption and displace food substances
causes of iron deficiency and anemia
- malnutrition and inadequate iron intake
- lack of food
- high consumption of wrong foods
non-nutritional causes of anemia
losses or increased need
1. blood loss - 80% of iron is stored in blood
2. GI bleed
2. women in reproductive years
what populations need increased iron to support growth of new tissue?
- infants over 6 months
- children and adolescents
- pregnant women
what is the most common nutrient deficiency?
iron - 1.2 billion people
iron toxicity
- toxic in large amounts
- difficult to excrete once absorbed
iron overload
hemochromatosis
how does the body defend against iron overload?
controlling its entry (hepcidin)
hepcidin
a hormone secreted by liver that limits iron absorption
controlling entry of iron
- small intestine traps some iron and holds it within boundaries (mucosal cells)
- when mucosal cells are shed, excess iron they collected is lost from the body
- when iron stores are filled, less iron is absorbed - protects from iron over load
hemochromatosis
an inherited disease in which the body absorbed too much iron
- genetic component to iron overload