Lecture 8 Flashcards

1
Q

minerals

A

inorganic elements that retain their chemical identity (not destroyed by cooking or storing)

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2
Q

the trace minerals

A
  1. iodine
  2. iron
  3. zinc
  4. sulphur
  5. selenium
  6. fluoride
  7. chromium
  8. copper
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3
Q

iodine function

A
  1. integral part of thyroxine (hormone)
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4
Q

thyroxine

A

hormone made by thyroid gland
- regulation of basal metabolic rate

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5
Q

iodine deficiency symptoms

A
  1. enlarged thyroid (goiter)
  2. sluggishness
  3. weight gain
  4. severe deficiency during pregnancy can cause congenital hypothyroidism
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6
Q

goiter

A

enlarged thyroid to trap iodine

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7
Q

congenital hypothyroidism

A
  1. extreme irreversible mental and physical developmental delay
  2. most preventable causes of intellectual delay
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8
Q

what foods cause iodine deficiency?

A

collards, kate and brussel sprouts
- contain goitrogens which inhibit iodine uptake by thyroid

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9
Q

iodine toxicity

A
  1. enlarged thyroid glant
  2. can be deadly in very large amounts
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10
Q

sources of iodine

A
  1. seafood (from ocean)
  2. iodized salt
    - amount varies with amount in soil in which plants are grown or on which animals graze
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11
Q

iodized salt

A

less than 1/2 tsp meets an entire days recommendation

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12
Q

sea salt and iodine

A

sea salt contains very little iodine
- dry all of it out and iodine is blown away

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13
Q

iron

A

essential nutrient and deficiency is problem for many

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14
Q

what contains most of the body’s iron?

A

hemoglobin and myoglobin

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15
Q

hemoglobin

A

oxygen-carrying protein of red blood cells

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16
Q

myoglobin

A

oxygen-holding protein of muscles

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17
Q

iron function

A
  1. carried oxygen
  2. helps many enzymes use oxygen
  3. needed to make new cells, amino acids, hormones and , neurotransmitters
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18
Q

iron storage and excretion

A
  1. liver puts iron into red blood cells sent from bone marrow
  2. RBCs die after 3-4 months and the liver and spleen break them down and recycle their iron
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19
Q

how is iron balance maintained?

A

through absorption

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20
Q

iron loss

A
  1. small amounts of iron is loss in nail clippings, hair cutting, shed skin cells
  2. loss of iron from bleeding can be significant
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21
Q

obtaining iron

A

only approx. 10-15% of iron is absorbed
1. absorption increases with diminished body supply and with need
2. absorption decreases when iron is abundant

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22
Q

ferritin

A

an iron storage where protein stores iron in the mucosal cells of small intestine

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22
Q

what happens when iron is needed?

A

iron is released to transferrin and travels through blood to body

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23
Q

what happens when iron is not needed?

A

iron is shed with the intestinal cells which are replaced every 3-5 days

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24
Q

free iron

A

powerful oxidant
- can start free-radical reactions that damages cells

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25
Q

iron deficiency

A

result of iron absorption not compensating for losses or low dietary intakes

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26
Q

decreased iron stores

A

stage I iron deficiency

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27
Q

depleted iron stores

A

stage II iron deficiency

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28
Q

iron deficiency anemia

A

depletion of iron stores resulting in low blood hemoglobin (stage 3 deficiency)
- people can be iron deficient without being anemic

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29
Q

anemia results

A

cells contain too little hemoglobin and thus deliver too little oxygen which limits cells metabolism

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30
Q

symptoms of anemia

A
  1. tiredness
  2. apathy
  3. a tendency to feel cold
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31
Q

what are symptoms of an iron deficiency often mistaken for?

A

behavioural or emotional problems

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32
Q

pica

A

craving non-food substances
- occurs with iron deficiency sometimes
- inhibit iron absorption and displace food substances

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33
Q

causes of iron deficiency and anemia

A
  1. malnutrition and inadequate iron intake
  2. lack of food
  3. high consumption of wrong foods
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34
Q

non-nutritional causes of anemia

A

losses or increased need
1. blood loss - 80% of iron is stored in blood
2. GI bleed
2. women in reproductive years

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35
Q

what populations need increased iron to support growth of new tissue?

A
  1. infants over 6 months
  2. children and adolescents
  3. pregnant women
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36
Q

what is the most common nutrient deficiency?

A

iron - 1.2 billion people

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37
Q

iron toxicity

A
  1. toxic in large amounts
  2. difficult to excrete once absorbed
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38
Q

iron overload

A

hemochromatosis

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39
Q

how does the body defend against iron overload?

A

controlling its entry (hepcidin)

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40
Q

hepcidin

A

a hormone secreted by liver that limits iron absorption

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41
Q

controlling entry of iron

A
  1. small intestine traps some iron and holds it within boundaries (mucosal cells)
  2. when mucosal cells are shed, excess iron they collected is lost from the body
  3. when iron stores are filled, less iron is absorbed - protects from iron over load
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42
Q

hemochromatosis

A

an inherited disease in which the body absorbed too much iron
- genetic component to iron overload

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43
Q

what population is hemochromatosis most common amongst?

A

caucasian men

44
Q

hemochromatosis process

A

intestine continues to absorb iron at high rate despite the excess iron building up in the body tissues

45
Q

early symptoms of hemochromatosis

A
  1. fatigue
  2. mental depression
  3. abdominal pains
46
Q

later symptoms of hemochromatosis

A
  1. tissue damage
  2. liver failure
  3. abnormal heart beats
  4. diabetes type II
  5. likely infections because bacteria thrive on iron-rich blood
47
Q

high-level iron fortification of foods

A
  1. pose no risk for healthy people
  2. many canadians take vitamin C supplements, which enhances iron absorption
48
Q

iron supplements

A
  1. can reverse iron-deficiency anemia from dietary causes
  2. leading cause of fatal accidental poisonings among Canadian children under 6 years old
49
Q

adult men and iron

A

rarely experience iron-deficiency anemia

50
Q

vegetarians and iron

A

advised to obtain 1.8 times RDA
- iron in plant foods not well-absorbed
- diets lack factors from meat that enhance iron absorption

51
Q

food vs supplement (iron)

A
  1. food is best source = better absorption
  2. pregnant women need an iron supplement
52
Q

2 forms of iron in foods

A
  1. heme iron
  2. non-heme iron
53
Q

heme iron

A

iron-containing part of hemoglobin and myoglobin found in meat, poultry and fish (bound to heme)

54
Q

non-heme iron

A

found in foods from plants and meat, poultry and fish

55
Q

is heme iron of non-heme iron absorbed better?

A

heme iron

56
Q

MFP factor

A
  1. found in meat, fish, poultry
  2. promotes absorption of non-heme iron from other foods sources eaten at the same time
57
Q

vitamin C and iron

A

can help absorption of iron from foods eaten in the same meal

58
Q

impairment of iron absorption

A
  1. tannins
  2. calcium and phosphorus (milk)
  3. phylates
59
Q

tannins

A

found in tea and coffee
- black tea is exceptional in its efficiency in reducing iron absorption (advisable for iron over load)

60
Q

phylates

A

found in fibre of lightly processes legumes and whole-grain cereals

61
Q

sources of iron

A
  1. red meats, fish, poultry, shellfish, eggs
  2. legumes, green leafy veggies, dried fruit
  3. cooking in iron pan adds iron
62
Q

zinc

A

small quantity in human body

63
Q

zinc functions

A
  1. works with proteins in every body organ
  2. helps more than 300 enzymes
  3. assists in immune function
  4. regulation of gene expression in protein synthesis
  5. taste perception
  6. wound healing
  7. sperm production
  8. fetal development
  9. growth and development in children
    10.affects behaviour and learning
  10. produces active form of Vitamin A in visual pigments
    12.
64
Q

what functions does zinc help 300 enzymes do?

A
  1. make parts of cell’s genetic material
  2. make heme in hemoglobin
  3. assist the pancreas with digestive functions
  4. help metabolize carbs, proteins, fat
  5. liberate vitamin A from storage in the liver
65
Q

zinc deficiency symptoms

A
  1. adverse growth
  2. alters digestive functions and causes diarrhea (worsen malnutrition)
  3. impairs immune response (more infections - worsen malnutrition)
  4. poor wound healing
  5. abnormal taste
  6. abnormal vision in the dark
66
Q

what is zinc deficiency often misdiagnosed as?

A

general malnutrition and sickness because symptoms are so vast

67
Q

pancreatic juices and zinc

A

pancreatic juices are rich in zinc, so after a meal, the body gets zinc from the food and pancreatic enzymes

68
Q

where is zinc primarily lost?

A

in the feces

69
Q

zinc toxicity

A
  1. can cause serious illness or death (supplements only)
  2. may reduce blood conc of HDL
  3. can inhibit copper absorption and lower bodys copper content
  4. inhibit iron absorption
70
Q

zinc absorption

A
  1. varies from 15-40%
  2. absorption decreases with increased intake
  3. absorption limited by phytates
71
Q

food sources of zinc

A
  1. meats
  2. shellfish
  3. poultry
  4. milk and milk products
72
Q

plant sources of zinc

A

no absorbed as well as animal sources
1. some legumes
2. whole grains

73
Q

selenium functions

A
  1. works as an antioxidant (prevents oxidative harm)
  2. activates thyroid hormone
  3. similar to sulfur and can occur in place of sulfur in amino acids
74
Q

what can selenium deficiency lead to?

A
  1. cancer
  2. heart disease
75
Q

cancer due to selenium deficiency

A

low blood selenium correlated with them development of some forms of cancer (prostate)

76
Q

heart disease due to selenium deficiency

A

associated with keshan disease

77
Q

keshan disease

A

heart enlargement and insufficiency
- selenium deficiency may predispose people to the disease
- adequate selenium seems to prevent keshan disease

78
Q

selenium toxicity

A

long-term supplementation

79
Q

selenium toxicity symptoms

A
  1. nausea
  2. abnormal pain
  3. hair loss
  4. nerve abnormalities
80
Q

selenium sources

A
  1. meats
  2. shellfish
  3. veggies and grains grown in selenium-rich soils
81
Q

selenium supplements

A

no benefits seen from selenium supplements unless selenium deficient

82
Q

fluoride

A

not essential to life but if beneficial

83
Q

fluoride functions

A
  1. crystalline deposits in bone and teeth
    - forms more decay-resistent fluorapatite in developing teeth
84
Q

sources of fluoride

A
  1. primary = fluoride drinking water
  2. tea and seafood
85
Q

fluoride deficiency

A

where fluoride is missing the incidence of dental decay is high

86
Q

fluridation

A

practical, safe and cost-effective way to help prevent dental caries in the young

87
Q

fluoride toxicity

A

fluorosis - discolouration and pitting of tooth enamel caused by excess fluoride during tooth development (irreversible)

88
Q

chromium function

A

works closely with insulin to regulate and release energy from glucose

89
Q

chromium deficiency

A
  1. impaired insulin action
    - results in diabetes-like conditions of high BP
    - resolves chromium supplementation
90
Q

chromium supplements

A

cannot cure common forms of diabetes

91
Q

sources of chromium

A
  1. unrefined foods and whole grains (lost during processing)
  2. liver
  3. whole grains
  4. nuts and cheeses
92
Q

copper function

A
  1. formation of hemoglobin and collagen
  2. many enzymes depend on copper for its oxygen-handing ability
  3. role in handling of iron
  4. assists in reactions leading to release of energy
  5. copper-dependent enzyme (superoxide dismutase) helps contorl damage from free-radical activity in the tissues
93
Q

copper deficiency

A
  1. rare
  2. can be caused by excess zinc
  3. menkes disease
94
Q

menkes disease

A

intestinal cells absorb copper but can’t release it into circulation causing deficiency

95
Q

symptoms of menkes disease

A
  1. can severely disturb growth and metabolism
  2. can impair immunity an blood flow through arteries
96
Q

copper toxicity

A
  1. unlikely from foods
  2. can be caused by supplementation
  3. wilsons disease
97
Q

wilsons disease

A

copper accumulates in the liver and the brain

98
Q

copper sources

A
  1. organ meats
  2. seafood
  3. nuts and seeds
  4. whole grains
  5. water may supple copper (especially with copper plumbing pipes)
    - in canada, copper intakes are adequate
99
Q

other trace minerals

A
  1. molybdenum
  2. manganese
  3. boron
  4. cobalt
  5. nickel
  6. silicon
  7. arsenic
100
Q

molybdenum

A

functions as a part of several metal-containing enzyme

101
Q

manganese

A

works with enzymes

102
Q

boron

A

influences activity of many enzymes

103
Q

cobalt

A

mineral in vitamin B12
- other name for vitamin B12 is cobalamin

104
Q

nickel

A

important for the health of many body tissues

105
Q

nickel deficiency

A

harm to the liver and other organs

106
Q

silicon

A

bone calcification in animals

107
Q

arsenic

A
  1. a known poison and carcinogen
  2. may turn out to be essential in small quantities
108
Q

trace minerals toxicity

A
  1. all trace minerals can be toxic in excess
  2. overdoses are most likely to occur in those who take supplements