Lecture 8 Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

CML (Chronic Myelogenous Leukemia)

A

Characteristics: increased number of granulocytes and their precursors in the peripheral blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Philadelphia Chromosome

A

Comes from a chromosomal translocation between chromosomes 9 & 22 (responsible for CML)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Bcr-Abl

A

Oncogene produced by the chromosomal translocation in CML
- non receptor tyrosine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Gleevec pt. I

A

Primary drug used for targeted therapy of CML
Tyrosine kinase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Gleevec pt. II

A

Success: almost all CML patients have a complete response to Gleevec
For most patients responses last for years but drug resistance develops in ~10-15% of patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Gleevec Resistance

A

Bcr-Abl gene amplification & mutation of Bcr-Abl decreases Gleevec binding affinity
Treated using Dasatinib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Metastatic Melanoma

A

Generated by mutated melanocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

B-raf (V600E)

A

Primary driver oncogene for metastatic melanomas
Serine/threonine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PLX 4032 (Zelboraf)

A

Treated metastatic melanomas and targeted B-raf (V600E)
Also inhibits regular B-raf but at a 10-fold higher drug concentration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

PLX 4032 pt. II

A

High % of patients achieved large success responses, but resistance developed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Resistance to PLX 4032

A

Up-regulation of PDGF receptors which activated a new survival pathway
Also mutation of N-ras which stimulated c-RAF to reactivate MAPK survival pathways

How well did you know this?
1
Not at all
2
3
4
5
Perfectly