Lecture 7.1 : Development of B lymphocytes

Question 1

B cells mature where?

Answer 1

Lymph node

Question 2

Six phases of B cell development

Answer 2

1. Repertoire assembly
2. Negative selection
3. Positive selection
4. Searching for infection
5. Finding it
6. Attacking infection

Question 3

Which phases of B cell development are antigen-independent?

Answer 3

Steps 1-4

Question 4

Steps 1 and 2 take place in ______

Answer 4

the bone marrow

Question 5

Which are the antigen-dependent steps?

Answer 5

5. Finding infection
6. Attacking infection

Question 6

During B cell development, pluripotent stem cells develop into

Answer 6

Pro-B cells

Question 7

Stem cells are characterized by ____ marker

Answer 7

CD34

Question 8

_____ receptor on B cell precursor will drive further differentiation

Answer 8

IL-7Ra

Question 9

Cellular stages of B cell development

Answer 9

1. Lymphoid Progenitor
2. Early Pro
3. Late Pro
4. Pre-B
5. Immature B

Question 10

Stromal cells contain ___, which is an important signaling molecule for _______ (stage) during B cell development.

Answer 10

IL-7

Late Pro-B cell

Question 11

There are two chances for productive rearrangement of _______ during B cell development.

When do these occur?

Answer 11

IgH gene segment rearrangement

These occur in the Early pro-B cell and Late Pro-B cell stages

Question 12

Early ProB cell IgH rearrangement involves ____ segments

Answer 12

D-J

Question 13

Late ProB cell H chain rearrangement involves____ segments

Answer 13

V-DJ