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Immunology > Lecture 3: Hematopoiesis > Flashcards

Lecture 3: Hematopoiesis Flashcards

1
Q

Hematopoiesis is regulated by what cytokines?

A

SCF

IL–1,3,6,7

CSF (G, GM, M)

EPO

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2
Q

B and T lymphocytes stem from

A

Common lymphoid progenitor

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3
Q

Multipotential hematopoietic stem cell can differentiate into ____ and _____

A

Common Myeloid Prog.

Common Lymphoid Prog.

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4
Q

These IL’s stilumate TCell differentiation

A

1,2,4,6,7

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5
Q

These factors stimulate differentiation into common myeloid progenitor

A

IL1,3,6

GM-CSF

SCF

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6
Q

These factors signal differentiation to common lymphoid progenitor

A

IL- 2,7,12

SDF-1

TNF-a. TGF-B2

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7
Q

Hematopoiesis occurs in _____ in adults

A

Bone marrow

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8
Q

Hematopoietic stem cells are ____ and ______

A

self-renewing

totipotent

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9
Q

HSC’s make ___, ____, and ______

A

Immune cells, Platelets, RBC’s

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10
Q

Dendritic Cells can originate from what cells?

A

Monocytes

(usually) MQ/DC Precursor cell

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11
Q

T cell contains ______ Antigen receptor

A

T cell

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12
Q

B cell contains ____ Antigen receptor

A

B cell

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13
Q

NK cells contain _____ Antigen receptor

A

they contain NO antigen-specific receptor

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14
Q

ILC cells contain _______ Antigen receptor

A

No antigen-specific receptor

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15
Q

Small Lymphocyte cell function

A

Production of Ab’s (B cells ) or helper and cytotoxic functions (T Cells)

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16
Q

Eosinphils kill ____ via ____

A

parasites, granule release

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17
Q

Neutrophil major surface marker

A

CD15

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18
Q

Neutrophils induced by

A

IL3

GM-CSF

G-CSF

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19
Q

Neutrophil antigen receptor:

A

None

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20
Q

Monocytes are precursors to

A

MQ’s and SOME DC’s

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21
Q

Antigen receptors on monocytes:

A

None

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22
Q

Major surface marker on Monocytes

A

CD14

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23
Q

These induce monocytes

A

IL3

GM-CSF

M-CSF

24
Q

Eosinophils kill what specifically

A

Ab-Coated parasites

25
Q

Eosinophil antigen receptors:

26
Q

Eosinophil effector machinery

A

Cytotoxic granules

lipid mediators

cytokines + chemokines

27
Q

What induces eosinophil proliferation

A

T/Mast/Eosinophil-derived IL5

28
Q

Eosinophils have ___ and ___ receptors

29
Q

Mast cells two functions

A

Kill parasites

Mediate Allergic response

30
Q

Mast cell antigen receptor

31
Q

Mast cell surface receptor

A

IgE receptor

32
Q

Mast cells found in…

A

Connective tissues

33
Q

Mast cells produce…

A

Cytokines

IL 4, 5, 6, 13

34
Q

______ induces mast cells

A

Stem Cell Factor (SCF)

35
Q

Basophil functions

A
  • effector cells in allergic disorders
  • responds to parasites
36
Q

Basophil receptor (sensor)

A

IgE receptor

37
Q

Effector Machinery of Basophils

A

cytotoxic granules, lipid mediators, chemokines/cytokines

38
Q

NK cell Antigen receptors

39
Q

NK cell effector machinery is _____ and ______

A

perforins and granzymes

40
Q

NK cell two receptor types and function

A

Fc and MHC

Fc activate

MHC inhibit

41
Q

NK cell surface markers

A

CD16, CD56

42
Q

T cells differentiate in ______

A

secondary lymphoid tissues

43
Q

T cells antigen receptors

44
Q

T cell functions:

A

Regulate Humoral and CMIR

45
Q

T cell effector mechanisms (3)

A

Cytokines

Cell Surface molecules

Cytotoxic Granules

46
Q

___ is the defining Antigen for all T cells

47
Q

Surface markers for T cells (3)

A

CD3, CD4, CD8

48
Q

B cell surface markers

A

CD19+

CD20+

49
Q

B cell Antigen receptors

A

YES!

B cell Receptor (cell surface IG)

50
Q

Function of B cells

A

Production of Immunoglobulins (GAME)

51
Q

B cells are regulated by ___

52
Q

B cells can also be activated…

A

Independently of T cells

53
Q

Most circulating WBCs are

A

Neutrophils (40-75%)

54
Q

Neutrophil enters _____ when there is ______

A

Tissue

Inflammation

55
Q

_______ are always entering the tissues

56
Q

Recombinant ____ and ____ help boost _______ for neutropenia.

A

GM-CSF

G-CSF

help boost Leukocyte production

57
Q

Recombinant ______ given for anemia patients?

Immunology (10 decks)

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