Lecture 7 - neuroimaging

Question 1

How many layers is the canonical circuit?

Answer 1

Organised in 6 layers

Question 2

Describe the organisation of the canonical circuit.

Answer 2

Composed of superficial pyramidal neurons of layers 2 and 3 receiving different inputs and deep pyramidal neurons of layer 5 that are responsible for cortex output.
Layer 1 has almost no brain cells.
Specific layers receive information and specific layers pass on information.
Central messenger for passing information around.

Question 3

What % of the cells in the neocortex is made up of excitatory cells?

Answer 3

80

Question 4

What % of cells in the neocortex is made up of inhibitory cells?

Answer 4

20

Question 5

What experiments were done to study single neuron function?

Answer 5

electrophysiology and all-optical physiology.

Question 6

What can an electrophysiology rig do?

Answer 6

study 2 cells simultaneously (can help see plasticity as brain cells form connections with one another).

Question 7

Problems with electrophysiology rig?

Answer 7

low yield - can only study very high resolution with very high precision.
Challenging to do batch recordings.