Lecture 18 - subcortical contributions to motor control Flashcards
1
Q
What does the lateral part of the cerebellum do?
A
processes information from cerebral cortex and sends it back to the cerebral cortex
2
Q
What does the intermediate part of the cerebellum do?
A
the spine-cerebellum, gets sensory input from the spinal cord
3
Q
What does the vestibular part of the cerebellum do?
A
gets information from the vestibular nuclei
4
Q
What are 3 effects of cerebellar lesions?
A
- hypermetria
- dysdiadochokinesia
- ataxic gate
5
Q
Describe the cerebellar microcircuit.
A
- Purkinje cell is the most important.
- dendrites project up the molecular layer, all arranged in one plane
6
Q
What are the 2 input cells of the cerebellar microcircuit?
A
- mossy fibre cells - synapse on the granule cell that projects the axon up to the molecular layer and intersect with the dendritic tree of Purkinje cells
- climbing fibres - input cells. one climbing fibre intercepts one Purkinje cell.
7
Q
Describe simple spikes.
A
- standard action potential
- high rates
- elicited by many parallel fibre synapses via temporal summation
8
Q
Describe complex spikes.
A
- massive depolarisation, causing calcium spike
- low rate
- 1:1 coupling with climbing fibre
- control LTD
9
Q
What is basal ganglia?
A
a number of nuclei that are under the cerebral cortex
10
Q
What is an example of basal ganglia disease?
A
parkinsons - lack of movement
11
Q
Describe Parkinson’s.
A
- loss of SNc dopaminergic cells
- less activity coming out of the SNc
- SNc inhibits indirect pathway so less activity = more active inhibitory pathway
- over activates GPi
- decrease of the direct pathway
- under activity in the thalamus and cortex
